2017
DOI: 10.18063/apm.2017.02.001
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Validation of novel multiplex technologies

Abstract: Cytokine and chemokine levels in body fluid provide information of altered conditions in patients. The parallel analysis of multiple factors, such as cytokines, from small sample sizes is an interesting approach for the assessment of in vivo activation signatures and functionality after ex vivo stimulation. One interesting application is for therapy monitoringsuch as safety data, pharmacodynamics, evidences for mode-of-action and side effects-which is particularly useful for accompanying early phase clinical t… Show more

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Cited by 2 publications
(1 citation statement)
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“…Results are summarized in Supplementary Table 3. While there were notable differences in the range of concentrations detected by the two different platforms, as shown previously by others (15)(16)(17)(18), overall the data confirm the significant decrease in HIV-1 induced immune activation and inflammation over the first 6 months of ART. Since the MSD Angiogenesis panel allows individual evaluation of VEGF-A, C, and D, it was interesting to find an increase over time in VEGF-D plasma concentrations (from median of 851 to 1046 pg/ml, p=0.0002, Supplementary Table 3).…”
Section: Multiplex Analysis Using Plasmasupporting
confidence: 88%
“…Results are summarized in Supplementary Table 3. While there were notable differences in the range of concentrations detected by the two different platforms, as shown previously by others (15)(16)(17)(18), overall the data confirm the significant decrease in HIV-1 induced immune activation and inflammation over the first 6 months of ART. Since the MSD Angiogenesis panel allows individual evaluation of VEGF-A, C, and D, it was interesting to find an increase over time in VEGF-D plasma concentrations (from median of 851 to 1046 pg/ml, p=0.0002, Supplementary Table 3).…”
Section: Multiplex Analysis Using Plasmasupporting
confidence: 88%