Validation of rebound tonometry for intraocular pressure measurement in the rabbit

Zhang, Hong; Dong, Yuchao; Ross, Craig; Wigg, Jonathan P.; Pandav, Surinder Singh; Crowston, Jonathan G

doi:10.1016/j.exer.2014.02.004

Cited by 34 publications

(50 citation statements)

References 36 publications

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“…Overall, the “D” mode (12.10 ± 0.42 mmHg) tended to have a higher IOP than the “P” mode (8.55 ± 0.36 mmHg) ( P < 0.001, Figure ). This is consistent with previous reports on IOP measurements with rebound tonometry in rabbits . There was no significant correlation between IOP and ICA parameters, or between IOP and gonioscopy grade.…”

Section: Resultssupporting

confidence: 92%

“…Individuals were randomly selected from a population of companion rabbits that were seeking adoption at the House Rabbit Society in Broomfield, Colorado. Inclusion criteria were as follows: normal neurophthalmic examination, normal anterior segment examination as determined with slit lamp biomicroscopy and fluorescein staining, normal appearance of the fundus as determined by fundoscopy, and a phenol red thread test of >15 mm/15 s and an IOP of <20 mmHg . Rabbits selected for the study had no known recent history of illness or other medical concerns.…”

Section: Methodsmentioning

confidence: 99%

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Iridocorneal angle assessment of companion rabbits using gonioscopy, spectral‐domain optical coherence tomography (Optovue iVue^®), high‐resolution ultrasound, and Pentacam^®HR imaging

Puma

Freeman

Cleymaet

et al. 2019

Veterinary Ophthalmology

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Objective: Iridocorneal angle (ICA) narrowing is a known risk factor for primary glaucoma in multiple species, but has not been described in companion rabbits. This study aimed to develop an ICA grading scheme for companion rabbits to enable early glaucoma predisposition diagnosis. Animals studied: Twenty healthy rabbits of varying breeds and ages. Procedures: Rabbits received complete ophthalmic examinations, including gonioscopy, and imaging of the ICA using spectral-domain optical coherence tomography (SD-OCT), Scheimpflug imaging (Pentacam ® HR), and high-resolution ultrasound (HRUS). Angle opening distance (AOD) and angle recess area (ARA) of the ICA were measured and assessed for agreement using a Bland-Altman analysis. A fivestage gonioscopy grading scheme was created, and Spearman-rank test assessed for correlation between gonioscopy grades and ICA measurements. Differences among age and sex were analyzed with a nonparametric ANOVA and Wilcoxon rank-sum test, respectively. Results: Analysis revealed AOD medians of 0.28mm for SD-OCT [95% CI: 0.24-0.31], 0.20mm for Pentacam ® HR [95% CI: 0.18-0.21], and 0.25mm for HRUS [95% CI: 0.22-0.28]. The median ARA was 0.14mm 2 for SD-OCT [95% CI: 0.117-0.163], 0.09mm 2 for Pentacam ® HR [95% CI: 0.082-0.100], and 0.06mm 2 for HRUS [95% CI: 0.046-0.054]. The association between gonioscopy grade and SD-OCT ARA was significant (P < 0.05), and there was a significant difference (P < 0.001) between imaging modalities for both ARA and AOD. Conclusions: Gonioscopy grade correlated well with SD-OCT ARA. Therefore, SD-OCT is recommended as a noncontact method for evaluating companion rabbit ICA.Each imaging device should not be used interchangeably for ICA evaluation. K E Y W O R D S gonioscopy, iridocorneal angle, rabbit, Scheimpflug imaging, SD-OCT, ultrasound | 835 LI PUMA et AL.

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Section: Resultssupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Iridocorneal angle assessment of companion rabbits using gonioscopy, spectral‐domain optical coherence tomography (Optovue iVue^®), high‐resolution ultrasound, and Pentacam^®HR imaging

Puma

Freeman

Cleymaet

et al. 2019

Veterinary Ophthalmology

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“…Several studies on various species have validated the use of the Tonovet through correlation with manometry, but no rebound tonometer has been validated in an anuran species. Cannizzo et al .…”

Section: Discussionmentioning

confidence: 99%

“…Several studies on various species have validated the use of the Tonovet through correlation with manometry, [18][19][20][21][22] but no rebound tonometer has been validated in an anuran species. Cannizzo et al 11 created calibration curves for both Tonovet and TonoLab in American Bullfrogs, but neither tonometer produced IOP readings that matched the manometer.…”

mentioning

confidence: 99%

Ophthalmic findings in a captive population of Panamanian golden frogs: Atelopus zeteki

Pelych¹,

Shellabarger

Vassallo

et al. 2019

Veterinary Ophthalmology

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Purpose The aim of this study was to describe normal ocular morphology and establish parameters for select diagnostics in a population of Panamanian Golden Frogs (PGF) Atelopus zeteki maintained at the Detroit Zoo. Method A total of 22 toads free of ocular disease were included in this study. Ophthalmic diagnostic tests included as follows: endodontic absorbent paper point tear test (EAPPTT), assessment of intraocular pressures (IOP), Rose Bengal stain, palpebral fissure width, blink rate and corneal cultures. Histology was performed on stored postmortem samples. Results Panamanian Golden Frogs have a distinct brow ridge and mobile third eyelid. Biomicroscopy revealed avascular, convex corneas with a shallow anterior chamber. Iris color ranged from yellow to green with dark pigmentation of the peripheral iris. Pupil shape was round. Posterior segment and fundus could not be visualized. Total number of blinks observed over a 10‐minute period was one. Mean EAPPTT was 2 ± 1 mm and 3 ± 1 mm in males and females, respectively (P). Mean IOP using rebound tonometry in horizontal and vertical restraint positions were 21.6 ± 2.28 mm Hg and 17.45 ± 3.66 mm Hg, 21.85 ± 2.7 mm Hg and 17.5 ± 3.93 mm Hg in males and females, respectively. Mean palpebral fissure width was 5.02 ± 0.46 mm and 6.12 ± 0.39 mm in males and females, respectively (P). Enterococcus faecalis was isolated from one clinically normal toad. Conclusions Tear production and blink rate were low and not significantly different between males and females. Intraocular pressure was significantly greater in male toads (P value <0.01). Females had a significantly larger palpebral fissure width when compared to males (P value <0.01) 5819. The ophthalmic parameters established in this study can aid in the evaluation and diagnosis of eye diseases in PGF.

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“…(The manufacturer-specified accuracy of the TonoVet utilized in our studies was ± 2 mm Hg.) Note that the TonoVet is not specifically calibrated by the manufacturer for rabbit corneal biomechanical properties, and its IOP readings from rabbits are known to be systematically lower than intraocularly determined manometric IOPs 86 . More precise and detailed characterization of our sensor's in vivo performance in subsequent work will require improved reference-IOP measurements in the eye.…”

Section: Discussionmentioning

confidence: 99%

A microscale optical implant for continuous in vivo monitoring of intraocular pressure

Lee

Park

et al. 2017

Microsyst Nanoeng

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Intraocular pressure (IOP) is a key clinical parameter in glaucoma management. However, despite the potential utility of daily measurements of IOP in the context of disease management, the necessary tools are currently lacking, and IOP is typically measured only a few times a year. Here we report on a microscale implantable sensor that could provide convenient, accurate, ondemand IOP monitoring in the home environment. When excited by broadband near-infrared (NIR) light from a tungsten bulb, the sensor's optical cavity reflects a pressure-dependent resonance signature that can be converted to IOP. NIR light is minimally absorbed by tissue and is not perceived visually. The sensor's nanodot-enhanced cavity allows for a 3-5 cm readout distance with an average accuracy of 0.29 mm Hg over the range of 0-40 mm Hg. Sensors were mounted onto intraocular lenses or silicone haptics and secured inside the anterior chamber in New Zealand white rabbits. Implanted sensors provided continuous in vivo tracking of short-term transient IOP elevations and provided continuous measurements of IOP for up to 4.5 months.

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Validation of rebound tonometry for intraocular pressure measurement in the rabbit

Cited by 34 publications

References 36 publications

Iridocorneal angle assessment of companion rabbits using gonioscopy, spectral‐domain optical coherence tomography (Optovue iVue^®), high‐resolution ultrasound, and Pentacam^®HR imaging

Iridocorneal angle assessment of companion rabbits using gonioscopy, spectral‐domain optical coherence tomography (Optovue iVue^®), high‐resolution ultrasound, and Pentacam^®HR imaging

Ophthalmic findings in a captive population of Panamanian golden frogs: Atelopus zeteki

A microscale optical implant for continuous in vivo monitoring of intraocular pressure

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Validation of rebound tonometry for intraocular pressure measurement in the rabbit

Cited by 34 publications

References 36 publications

Iridocorneal angle assessment of companion rabbits using gonioscopy, spectral‐domain optical coherence tomography (Optovue iVue®), high‐resolution ultrasound, and Pentacam®HR imaging

Iridocorneal angle assessment of companion rabbits using gonioscopy, spectral‐domain optical coherence tomography (Optovue iVue®), high‐resolution ultrasound, and Pentacam®HR imaging

Ophthalmic findings in a captive population of Panamanian golden frogs: Atelopus zeteki

A microscale optical implant for continuous in vivo monitoring of intraocular pressure

Contact Info

Product

Resources

About

Iridocorneal angle assessment of companion rabbits using gonioscopy, spectral‐domain optical coherence tomography (Optovue iVue^®), high‐resolution ultrasound, and Pentacam^®HR imaging

Iridocorneal angle assessment of companion rabbits using gonioscopy, spectral‐domain optical coherence tomography (Optovue iVue^®), high‐resolution ultrasound, and Pentacam^®HR imaging