Validation of the AnyBody full body musculoskeletal model in computing lumbar spine loads at L4L5 level

Bassani, Tito; Stucovitz, Elena; Qian, Zhihui; Briguglio, Matteo; Galbusera, Fabio

doi:10.1016/j.jbiomech.2017.04.025

Cited by 92 publications

(48 citation statements)

References 32 publications

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“…The dynamic measurement of continuous intervertebral motion in vivo is a relatively recent development, and intrasubject variation tests have tended to be limited to regional lumbar range of motion over short periods [12]. This has tended to confine the objective dynamic measurement of intervertebral function to cadaveric studies and computer models [13][14][15][16][17] providing little insight into individual living patients and representing a predicament in spine biomechanics research that has led to calls for in vivo, dynamic measurement methods of the multi-segmental spine and their validation. The hope is to make possible the production of individualised and, if possible, predictive models of functional spinal derangements [18,19].…”

Section: Introductionmentioning

confidence: 99%

Intrasubject repeatability of in vivo intervertebral motion parameters using quantitative fluoroscopy

2018

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Purpose In vivo quantification of intervertebral motion through imaging has progressed to a point where biomarkers for low back pain are emerging. This makes possible deeper study of the condition's biometrics. However, the measurement of change over time involves error. The purpose of this prospective investigation is to determine the intrasubject repeatability of six in vivo intervertebral motion parameters using quantitative fluoroscopy. Methods Intrasubject reliability (ICC) and minimal detectable change (MDC) of baseline to 6-week follow-up measurements were calculated for six lumbar spine intervertebral motion parameters in 109 healthy volunteers. A standardised quantitative fluoroscopy (QF) protocol was used to provide measurements in the coronal and sagittal planes using both passive recumbent and active weight-bearing motion. Parameters were: intervertebral range of motion (IV-RoM), laxity, motion sharing inequality (MSI), motion sharing variability (MSV), flexion translation and anterior disc height change during flexion. Results The best overall intrasubject reliability (ICC) and agreement (MDC) were for disc height (ICC 0.89, MDC 43%) and IV-RoM (ICC 0.96, MDC 60%), and the worst for MSV (ICC 0.04, MDC 408%). Laxity, MSI and translation had acceptable reliability (most ICCs > 0.60), but not agreement (MDC > 85%). Conclusion Disc height and IV-RoM measurement using QF could be considered for randomised trials, while laxity, MSI and translation could be considered for moderators, correlates or mediators of patient-reported outcomes. MSV had both poor reliability and agreement over 6 weeks. Graphical abstract These slides can be retrieved under Electronic Supplementary Material.

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Section: Introductionmentioning

confidence: 99%

Intrasubject repeatability of in vivo intervertebral motion parameters using quantitative fluoroscopy

2018

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“…Simulation studies of lifting tasks have also shown that the L4-L5 compression force increases with more spinal flexion. 15,18 The range of the resultant of the reaction force in the shoulder joint was 266-312 % of body weight, and therefore higher than the 150 % of body weight measured during daily activities. 13 This seems realistic because double poling is a very strenuous activity.…”

Section: Resultsmentioning

confidence: 95%

“…17 Validation studies of simulated compression forces between vertebrae L4 and L5 show good agreement to measured reactions. 15,18 Comparison between the AnyBody Modelling System and in vivo measurements 13 has shown quite good agreement for shoulder joint reactions. 19 In able-bodied cross-country skiing, lower back injuries are a common problem and believed to arise because of the large range of motion and monotony of lower back flexionextension.…”

Section: Introductionmentioning

confidence: 94%

Shoulder and Lower Back Joint Reaction Forces in Seated Double Poling

Ohlsson

Danvind

Holmberg

2018

Journal of Applied Biomechanics

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Overuse injuries in the shoulders and lower back are hypothesized to be common in cross-country sit-skiing. Athletes with reduced trunk muscle control mainly sit with the knees higher than the hips (KH). To reduce spinal flexion, a position with the knees below the hips (KL) was enabled for these athletes using a frontal trunk support. The aim of the study was to compare the shoulder joint (glenohumeral joint) and L4-L5 joint reactions of the KL and KH sitting positions. Five able-bodied female athletes performed submaximal and maximal exercise tests in the sitting positions KL and KH on a ski ergometer. Measured pole forces and 3-dimensional kinematics served as input for inverse-dynamics simulations to compute the muscle forces and joint reactions in the shoulder and L4-L5 joint. This was the first musculoskeletal simulation study of seated double poling. The results showed that the KH position was favorable for higher performance and decreased values of the shoulder joint reactions for female able-bodied athletes with full trunk control. The KL position was favorable for lower L4-L5 joint reactions and might therefore reduce the risk of lower back injuries. These results indicate that it is hard to optimize both performance and safety in the same sit-ski.

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“…Even in the 'gold standard' of lab based optical motion capture there is insufficient kinematics to drive all segments. The model therefore estimates the kinematics of the unmeasured segments using those of the measured segments (Wong et al, 2006;Bassani et al, 2017).…”

Section: Musculoskeletal Simulationmentioning

confidence: 99%

Thrust-versus-endurance trade-off optimization in swimming

Phillips

Hudson

Turnock

et al. 2019

Engineering Optimization

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In this paper we apply methods typically used in engineering applications to the optimization of human locomotion, more specifically a swimmer's underwater 'dolphin kick'. This is a dual-objective problem where we search for the optimal trade-off between thrust (simulated using Lighthill's fish propulsion method) and the force in the muscles to produce this thrust (simulated using musculoskeletal modelling). The expense of the analyses leads us to use a surrogate modelling based optimization technique (multi-objective expected improvement using Kriging). Our results indicate that optimal human motion does, in many respects follow that of fish, with low frequency eel-like techniques suitable for endurance and a high frequency tuna-like kick for high thrust. Matlab R code, including thrust and muscle activity models is included as supplementary material.

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Validation of the AnyBody full body musculoskeletal model in computing lumbar spine loads at L4L5 level

Cited by 92 publications

References 32 publications

Intrasubject repeatability of in vivo intervertebral motion parameters using quantitative fluoroscopy

Intrasubject repeatability of in vivo intervertebral motion parameters using quantitative fluoroscopy

Shoulder and Lower Back Joint Reaction Forces in Seated Double Poling

Thrust-versus-endurance trade-off optimization in swimming

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