An optimal payload selection conducted in the frame of the H2020 ONION project (id 687490) is presented based on the ability to cover the observation needs of the Copernicus system in the time period 2020–2030. Payload selection is constrained by the variables that can be measured, the power consumption, and weight of the instrument, and the required accuracy and spatial resolution (horizontal or vertical). It involved 20 measurements with observation gaps according to the user requirements that were detected in the top 10 use cases in the scope of Copernicus space infrastructure, 9 potential applied technologies, and 39 available commercial platforms. Additional Earth Observation (EO) infrastructures are proposed to reduce measurements gaps, based on a weighting system that assigned high relevance for measurements associated to Marine for Weather Forecast over Polar Regions. This study concludes with a rank and mapping of the potential technologies and the suitable commercial platforms to cover most of the requirements of the top ten use cases, analyzing the Marine for Weather Forecast, Sea Ice Monitoring, Fishing Pressure, and Agriculture and Forestry: Hydric stress as the priority use cases.