2018
DOI: 10.1038/s41375-018-0136-7
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Validation of the EUTOS long-term survival score in a recent independent cohort of “real world” CML patients

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Cited by 23 publications
(21 citation statements)
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“…11,14,[21][22][23][24][25] The cumulative 5-year CML-related death rate reported in our research was 11% in the ELTS high-risk group, 5% in the ELTS intermediate-risk group, and 2% in the ELTS lowrisk group. The data demonstrated there was higher incidence compared with the results reported in the confirmatory study by Geelen et al 18 Although the incidence was not exactly consistent, the ELTS score still distinguished the high-risk group with a significantly higher rate of disease-related death than the other risk groups. Most notably, the ELTS score outperformed the previously established Sokal, Hasford and EUTOS scores without statistical difference among different risk groups.…”
Section: Discussioncontrasting
confidence: 45%
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“…11,14,[21][22][23][24][25] The cumulative 5-year CML-related death rate reported in our research was 11% in the ELTS high-risk group, 5% in the ELTS intermediate-risk group, and 2% in the ELTS lowrisk group. The data demonstrated there was higher incidence compared with the results reported in the confirmatory study by Geelen et al 18 Although the incidence was not exactly consistent, the ELTS score still distinguished the high-risk group with a significantly higher rate of disease-related death than the other risk groups. Most notably, the ELTS score outperformed the previously established Sokal, Hasford and EUTOS scores without statistical difference among different risk groups.…”
Section: Discussioncontrasting
confidence: 45%
“…Few studies have validated the effectiveness of the ELTS score in clinical trials or in real-life setting. 17,18,21 Our study strongly provided positive evidence to support that the ELTS score is a significant risk stratification measure for CML-CP patients treated with imatinib. However, there are certain limitations in our real-world study.…”
Section: Discussionmentioning
confidence: 53%
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“…These risk scores were designed to evaluate differences in survival [21,22] or response [23]. Since most patients now die from causes other than leukemia while still in remission, a fourth risk score has been developed to predict the probability of dying from CML (leukemia-related death, LRD): the new EUTOS Long Term Survival (ELTS) score [24][25][26]. The ELTS score, based on TKI-treated patients, uses the same simple hematologic data, spleen size, and age as Sokal.…”
Section: Baseline Prognostic Factorsmentioning
confidence: 99%