Validation of the Modified Checklist for Autism in Toddlers, Revised With Follow-up (M-CHAT-R/F)

Robins, Diana L.; Casagrande, Karís; Barton, Marianne; Chen, Chi Ming; Dumont-Mathieu, Thyde; Fein, Deborah

doi:10.1542/peds.2013-1813

Cited by 806 publications

(753 citation statements)

References 25 publications

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“…16 Thoughtful review of parental perceptions of their child's behaviors for these 1% of cases using M-CHAT/F acknowledges the importance of parental observations, supports the need for referral, and activates follow-through. Use of a computerized algorithm to guide the follow-up interview also shortens the interview for those endorsing large 9 number of behaviors because the process stops automatically when results either confirm or refute the initial M-CHAT screen result.…”

Section: Discussionmentioning

confidence: 99%

“…However, unlike the initial M-CHAT studies, this sample was derived completely from a community, primary care population with a participation rate similar to the latest M-CHAT community sample. 16 This limitation is not restricted to research studies, as similar suboptimal rates of successful referral from screening occur in practice. 30 The requirement to travel to an AC may have been an impediment because our subsequent study offered in-home assessments and had higher participation rates.…”

Section: Discussionmentioning

confidence: 99%

“…This study was conducted before publication of the revised M-CHAT 16 ; the original 23-item version was used. The revised M-CHAT/F contains slight wording changes and eliminates 3 items.…”

Section: Discussionmentioning

confidence: 99%

“…15 The M-CHAT authors have also noted that when the M-CHAT score is ≥8, the potential for false-positive screens in the absence of the follow-up interview is low enough that it can be omitted. 16 The M-CHAT is therefore intended to be implemented as a 2-stage screening test consisting of completion by the parent and, if positive, conducting the follow-up interview to clarify/correct failed items. This process is referred to as the Modified Checklist for Autism in Toddlers Follow-Up Interview (M-CHAT/F).…”

mentioning

confidence: 99%

“…The M-CHAT/F authors also suggest that the second stage of the procedure has clinical advantages in facilitating discussion between parents and providers about a child's behaviors that may indicate ASD or other developmental delays. 16 One limitation of the published research is that administration of the follow-up interview was almost exclusively completed by trained research assistants (RAs) during a telephone call completed an average of 2 or 3 months after the parent completed the M-CHAT 8, 13, 17 -19 ; 1 study indicated that "most" of the follow-up interviews were conducted later by telephone, with an unspecified number conducted by primary care physicians. 15 Another study documented use of the follow-up interview by a clinician during the same visit in which the M-CHAT was completed by the parent.…”

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confidence: 99%

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Autism Screening With Online Decision Support by Primary Care Pediatricians Aided by M-CHAT/F

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…This study was conducted before publication of the revised M-CHAT 16 ; the original 23-item version was used. The revised M-CHAT/F contains slight wording changes and eliminates 3 items.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Autism Screening With Online Decision Support by Primary Care Pediatricians Aided by M-CHAT/F

et al. 2016

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Screening for Autism Spectrum Disorder in Young Children

Siu

Bibbins‐Domingo

Grossman

et al. 2016

JAMA

221

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The USPSTF concludes that there is insufficient evidence to assess the balance of benefits and harms of screening for ASD in children aged 18 to 30 months for whom no concerns of ASD have been raised. Evidence is lacking, of poor quality, or conflicting, and the balance of benefits and harms cannot be determined. Clinical Considerations Patient Population Under Consideration This recommendation applies to children who have not been diagnosed with ASD or developmental delay and for whom no concerns of ASD have been raised by parents, other caregivers, or health care professionals (Figure 2).

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Autism Spectrum Disorder

Hirota

King

2023

JAMA

276

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ImportanceAutism spectrum disorder (ASD), characterized by deficits in social communication and the presence of restricted, repetitive behaviors or interests, is a neurodevelopmental disorder affecting approximately 2.3% children aged 8 years in the US and approximately 2.2% of adults. This review summarizes evidence on the diagnosis and treatment of ASD.ObservationsThe estimated prevalence of ASD has been increasing in the US, from 1.1% in 2008 to 2.3% in 2018, which is likely associated with changes in diagnostic criteria, improved performance of screening and diagnostic tools, and increased public awareness. No biomarkers specific to the diagnosis of ASD have been identified. Common early signs and symptoms of ASD in a child’s first 2 years of life include no response to name when called, no or limited use of gestures in communication, and lack of imaginative play. The criterion standard for the diagnosis of ASD is a comprehensive evaluation with a multidisciplinary team of clinicians and is based on semistructured direct observation of the child’s behavior and semistructured caregiver interview focused on the individual’s development and behaviors using standardized measures, such as the Autism Diagnostic Observation Schedule-Second Edition and the Autism Diagnostic Interview. These diagnostic measures have sensitivity of 91% and 80% and specificity of 76% and 72%, respectively. Compared with people without ASD, individuals with ASD have higher rates of depression (20% vs 7%), anxiety (11% vs 5%), sleep difficulties (13% vs 5%), and epilepsy (21% with co-occurring intellectual disability vs 0.8%). Intensive behavioral interventions, such as the Early Start Denver Model, are beneficial in children 5 years or younger for improvement in language, play, and social communication (small to medium effect size based on standardized mean difference). Pharmacotherapy is indicated for co-occurring psychiatric conditions, such as emotion dysregulation or attention-deficit/hyperactivity disorder. Risperidone and aripiprazole can improve irritability and aggression (standardized mean difference of 1.1, consistent with a large effect size) compared with placebo. Psychostimulants are effective for attention-deficit/hyperactivity disorder (standardized mean difference of 0.6, consistent with a moderate effect size) compared with placebo. These medications are associated with adverse effects including, most commonly, changes in appetite, weight, and sleep.Conclusions and RelevanceASD affects approximately 2.3% of children aged 8 years and approximately 2.2% of adults in the US. First-line therapy consists of behavioral interventions, while co-occurring psychiatric conditions, such as anxiety or aggression, may be treated with specific behavioral therapy or medication.

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Validation of the Modified Checklist for Autism in Toddlers, Revised With Follow-up (M-CHAT-R/F)

Cited by 806 publications

References 25 publications

Autism Screening With Online Decision Support by Primary Care Pediatricians Aided by M-CHAT/F

Autism Screening With Online Decision Support by Primary Care Pediatricians Aided by M-CHAT/F

Screening for Autism Spectrum Disorder in Young Children

Autism Spectrum Disorder

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