Validation of the Persian Version of IMPACT-III Quality of Life Questionnaire in Iranian Children with Inflammatory Bowel Disease

Abstract

Background: Inflammatory bowel diseases (IBD) can adversely affect children in many different ways. Health-related quality of life (HRQOL) involves all aspects of life quality, along with physical or mental perceptions of health, which could exert an overall effect on an individual's health. The IMPACT-III questionnaire is a well-established and validated tool for evaluation of the HRQOL in children with IBD. Objectives: The objective of this work was to translate this tool into Persian so it could be utilized in Iran. Methods: In collaboration with the developer of IMPACT-III, a standardized translation and validation process was undertaken. Assessment steps included (1) translation of IMPACT-III into Persian; (2) assessment of the clarity and wording of the tool; and (3) ascertain the reliability and validity of the adapted instrument using a test-retest assessment. Patient scores were evaluated within four domains (social performance, body image, emotional and physical dimensions) and analysis undertaken with SPSS (version 16). The study was completed in Mashhad and

Systematic Review of Probiotics for Cystic Fibrosis Patients

“…Positive results for secondary outcomes were reported in 6 studies, including reduced serum levels of nitric oxide metabolites or rectal NO production (11,16); decreased hospital admissions (17); improved quality of life (20,22); and positive changes in the intestinal microbiota (23).…”

“…The 9 studies included in this systematic review (Bruzzese et al, 2004 (16), Bruzzese et al, 2007 (17), Weiss et al, 2010 (18), Fallahi et al, 2013 (19), Del Campo et al, 2014 (20), Di Nardo et al, 2014 (21), Jafari et al, 2013 (22), Bruzzese et al, 2014 (23), Bruzzese et al, 2017(12), and de Freitas et al, 2017 (11)) are described in Table 1 part A. The study excluded from the analysis is also described in Table 1 part B: Infant Pina et al, 2008 (15).…”

“…All included studies were considered to have a high risk of bias for the main measures according to the Cochrane Handbook criteria (13), as demonstrated in Figure 1; for this reason, a metaanalysis was not performed. Regarding treatment masking, 5 studies were randomized double-blinded trials (12,(19)(20)(21)23), while 1 study used a single-blind strategy (17), 2 were opened pilot studies (16,18), and 2 studies did not report blinding procedures (11,22).…”

Quality of life in Malaysian children with inflammatory bowel disease: An understudied population

“…The mean total IMPACT-III score from current cohort was 68.44. A recent study by Jafari et al 22 on the HRQoL of 89 Persian children reported mean total IMPACT-III score of 57.11. The score was much lower as compared to our study likely contributed by the larger proportion of children with active disease (46%) compared to our study (33.3%).…”

“…The mean total IMPACT‐III score from current cohort was 68.44. A recent study by Jafari et al 22 . on the HRQoL of 89 Persian children reported mean total IMPACT‐III score of 57.11.…”