Validation of the RightLevelpH Detector for Monitoring Gastric pH

Lambert, Charles R.; Varlotta, David; Posey, Marjorie; Heberlein, Jadie L.; Shirley, Janice M.

doi:10.4037/ajcc2015211

Cited by 1 publication

(1 citation statement)

References 23 publications

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“…Increased acid secretion might cause gastroesophageal reflux disease, while decreased acid secretion is related to chronic atrophic gastritis, dyspepsia, and infections. During the treatment of stomach diseases, commonly used clinical methods for detecting gastric acid levels, such as nasogastric intubation [ 2 ] or Heidelberg capsule [ 3 ], are complicated and expensive to perform. Generally, antacids are administered in combination with acid inhibitors and gastric mucosal protectants to neutralize excess stomach acid, either at the onset of symptoms (heartburn) or before (after meals or before sleep).…”

Section: Introductionmentioning

confidence: 99%

Assembled pH-Responsive Gastric Drug Delivery Systems Based on 3D-Printed Shells

Bei,

Zhao,

Shen

et al. 2024

Pharmaceutics

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Gastric acid secretion is closely associated with the development and treatment of chronic gastritis, gastric ulcers, and reflux esophagitis. However, gastric acid secretion is affected by complex physiological and pathological factors, and real-time detection and control are complicated and expensive. A gastric delivery system for antacids and therapeutics in response to low pH in the stomach holds promise for smart and personalized treatment of stomach diseases. In this study, pH-responsive modular units were used to assemble various modular devices for self-regulation of pH and drug delivery to the stomach. The modular unit with a release window of 50 mm2 could respond to pH and self-regulate within 10 min, which is related to its downward floatation and internal gas production. The assembled devices could stably float downward in the medium and detach sequentially at specific times. The assembled devices loaded with antacids exhibited smart pH self-regulation under complex physiological and pathological conditions. In addition, the assembled devices loaded with antacids and acid suppressors could multi-pulse or prolong drug release after rapid neutralization of gastric acid. Compared with traditional coating technology, 3D printing can print the shell layer by layer, flexibly adjust the internal and external structure and composition, and assemble it into a multi-level drug release system. Compared with traditional coating, 3D-printed shells have the advantage of the flexible adjustment of internal and external structure and composition, and are easy to assemble into a complex drug delivery system. This provides a universal and flexible strategy for the personalized treatment of diseases with abnormal gastric acid secretion, especially for delivering acid-unstable drugs.

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Section: Introductionmentioning

confidence: 99%