Validation of the VapoMeter, a closed unventilated chamber system to assess transepidermal water loss vs. the open chamber Tewameter<sup>®</sup>

Paepe, Kristien De; Houben, Evi; Adam, Ralf; Wiesemann, Frank; Rogiers, Vera

doi:10.1111/j.1600-0846.2005.00101.x

Cited by 125 publications

(111 citation statements)

References 17 publications

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“…TEWL was measured using a VapoMeter (Delfin Technologies Ltd., Kuopio, Finland). The VapoMeter uses the closed-chamber measurement principle to determine the evaporation rate of water from skin [29]. High-frequency skin conductance was measured using the Skicon-200EX® (IBS Co. Ltd., Hamamatsu, Japan) skin surface hygrometer.…”

Section: Methodsmentioning

confidence: 99%

Developmental Changes in Skin Barrier and Structure during the First 5 Years of Life

Walters

Khanna

Chu

et al. 2016

Skin Pharmacol Physiol

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The structure of the stratum corneum (SC) and the corresponding skin barrier develops from before birth up to about 4 years of age. Large subject-to-subject variability within an age group requires a large population to observe trends in skin barrier properties over time. Barrier function, quantified by transepidermal water loss (TEWL) and SC thickness, was measured on the upper inner arm and dorsal forearm in subjects aged 3 months to 4 years (n = 171) and a subset of mothers (n = 44). The rate of skin surface area expansion as a function of age peaked before birth (∼90 cm²/week) and declined to a steady plateau (∼10 cm²/week) by 1 year of age. SC thickness increased and TEWL decreased, but did not reach adult values until 3-4 years of age. A better understanding of how skin hydration changes after birth suggests that barrier function may be related mechanistically to skin surface area expansion.

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Section: Methodsmentioning

confidence: 99%

Developmental Changes in Skin Barrier and Structure during the First 5 Years of Life

Walters

Khanna

Chu

et al. 2016

Skin Pharmacol Physiol

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“…16 The location of PICC insertion (arm, leg, left versus right) was not randomly assigned but was on the basis of the availability of a suitable insertion site. The contralateral site was treated with dressing alone.…”

Section: Methodsmentioning

confidence: 99%

Effect of chlorhexidine gluconate on the skin integrity at PICC line sites

et al. 2009

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Objective: To determine the effects of chlorhexidine gluconate (CHG) on skin inflammation and stratum corneum barrier integrity at peripherally inserted central catheter (PICC) sites among patients in the neonatal intensive care setting.Study Design: In a within-subject design, PICC sites with CHG plus semipermeable dressing (PICC) were compared with contralateral dressing sites and untreated controls among 40 neonates (gestational age 32.1 ± 4.7) at weekly dressing changes, using quantitative measures of skin erythema, dryness and barrier integrity (transepidermal water loss, TEWL). Data were analyzed using analysis of variance and linear mixed methods.Results: At week 1, all three sites differed for erythema with the highest value indicating poorer skin condition at the PICC site. Dressing-site erythema was higher than the untreated control. Dryness and TEWL were higher, indicating poorer skin integrity, for the PICC site than either the dressing or the control. After 2 weeks, erythema and dryness scores were higher for the PICC site than the dressing and control skin. By week 3, scores were comparable for PICC and dressing sites and both were higher than the control for erythema and dryness. After 3 weeks, PICC skin TEWL was higher than both dressing and control and they did not differ from each other. Conclusion:The dressings used to secure PICC lines contribute to the observed skin compromise at CHG-treated skin sites and may affect skin barrier development in similar populations of neonates.

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“…Briefly, films specimens were mounted and sealed in the top of open specially designed cups filled with distilled water up to 1.1 cm from the film underside and left to equilibrate for 1 h at room temperature (22-23 • C, 42-46% RH). The Vapometer has a closed measuring chamber not sensitive to external airflows with a humidity sensor that enable measurements in normal room conditions [43]. Three film samples were tested for each type of film.…”

Section: Water Vapour Transmission Ratementioning

confidence: 99%

Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization

Silva

Pereira

Ramalho

et al. 2008

Journal of Membrane Science

117

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a b s t r a c tNovel chitosan based polyelectrolyte complexes (PEC) were developed and optimized in order to obtain films possessing the optimal functional properties (flexibility, resistance, water vapour transmission rate and bioadhesion) to be applied on skin. The development was based on the combination of chitosan and two polyacrylic acid (PAA) polymers with different crosslinkers and crosslinking densities. The interaction between the polymers was maximized controlling the pH, and by forming the films at a pH value close to the pK a of the respective components as identified by potentiometric and turbidimetric titrations. The action of glycerol, PEG200, Hydrovance and trehalose upon the functional properties of the films was also evaluated. Glycerol was found to improve the film properties in terms of flexibility, resistance and water vapour transmission rate (WVTR) with a maximum effect at 30%. The application of a pressure sensitive adhesive (PSA) significantly improved bioadhesion with a negligible influence in the resistance and flexibility of the films.The optimized film, including adhesive, has shown very good properties for application in the skin and represents a very promising formulation for further incorporation of drugs for topical and transdermal administration.

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Validation of the VapoMeter, a closed unventilated chamber system to assess transepidermal water loss vs. the open chamber Tewameter^®

Cited by 125 publications

References 17 publications

Developmental Changes in Skin Barrier and Structure during the First 5 Years of Life

Developmental Changes in Skin Barrier and Structure during the First 5 Years of Life

Effect of chlorhexidine gluconate on the skin integrity at PICC line sites

Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization

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Validation of the VapoMeter, a closed unventilated chamber system to assess transepidermal water loss vs. the open chamber Tewameter®

Cited by 125 publications

References 17 publications

Developmental Changes in Skin Barrier and Structure during the First 5 Years of Life

Developmental Changes in Skin Barrier and Structure during the First 5 Years of Life

Effect of chlorhexidine gluconate on the skin integrity at PICC line sites

Films based on chitosan polyelectrolyte complexes for skin drug delivery: Development and characterization

Contact Info

Product

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About

Validation of the VapoMeter, a closed unventilated chamber system to assess transepidermal water loss vs. the open chamber Tewameter^®