Validation of the web-based LUMINA questionnaire for recruiting large cohorts of migraineurs

Oosterhout, Wpj van; Weller, CM; Stam, AH; Bakels, F.; Stijnen, Theo; Ferrari, Michel D.; Terwindt, GM

doi:10.1177/0333102411418846

Cited by 59 publications

(89 citation statements)

References 25 publications

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“…The question on being diagnosed with migraine by a physician (question 2) was the least sensitive question in our cohort of stroke patients and had the lowest NPV. The low sensitivity of question 2 is in contrast with the results of a previous study that evaluated a short migraine screener in a cohort of people with migraine and found that this question had good test characteristics [11] . The different sensitivity of the question in the 2 cohorts can possibly be explained by the fact that in migraineurs, headache is the main reason to visit the physician, whereas persons in the stroke cohort might have less often visited their physician because of headache or migraine.…”

Section: Discussioncontrasting

confidence: 88%

“…Among all our patients with migraine, almost half had migraine with aura. The proportion of migraine with aura in our stroke cohort is higher than the 31% reported in migraine patients in general [11] .…”

Section: Discussioncontrasting

confidence: 79%

“…The MISS consisted of 5 questions with multiple choice answer options ( table 1 ): (1) whether the patient had ever had migraine attacks or still had these attacks (never; 1-4 times; ≥ 5 times; unknown); (2) whether a physician had ever diagnosed the patient with migraine (yes; no; unknown); (3) whether the patient had ever had a severe headache accompanied by nausea or vomiting (never; 1-4 times; ≥ 5 times; unknown); (4) whether the patient had ever had severe headache accompanied by hypersensitivity to lights and sounds (never; 1-4 times; ≥ 5 times; unknown) and (5) whether the patient had ever had visual disturbances lasting 5-60 min followed by headache (never; 1-2 times; ≥ 3 times; unknown). The MISS questionnaire was a short version of previous migraine screening questionnaires with which we have ample experience [9][10][11] . We made a short version of our previous screener to make it more suitable for clinical practice on the Stroke Unit.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Assessment of Migraine History in Patients with a Transient Ischemic Attack or Stroke; Validation of a Migraine Screener for Stroke

Willik

Pelzer²,

Algra³

et al. 2016

Eur Neurol

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Background: To investigate the connection between migraine and stroke, a reliable screening tool to gather information about a person's migraine history is crucial. We studied the test-characteristics of a 5-question Migraine Screener for Stroke (MISS). Methods: We included a random sample of patients with a transient ischemic attack or stroke who answered the MISS questionnaire when they were admitted to our hospital. After discharge, a semi-structured telephone interview was conducted to validate the migraine diagnosis with the International Classification of Headache Disorders, second-edition criteria as gold standard. Results: Forty-nine (22.2%) of the 221 included patients were diagnosed with life-time migraine (38.5% women, 7.7% men). The sensitivity of all questions combined was 0.47 (95% CI 0.31-0.62), the specificity was 0.97 (95% CI 0.93-0.99), the positive predictive value (PPV) was 0.80 (95% CI 0.59-0.93) and the negative predictive value (NPV) was 0.87 (95% CI 0.82-0.92). One question related to the presence of headache accompanied by hypersensitivity to lights and sounds had a better sensitivity (0.96, 95% CI 0.85-1.00) and NPV (0.99, 95% CI 0.95-1.00) than all questions put together. For assessing migraine with aura, the question about visual disturbances had a good NPV (0.99, 95% CI 0.96-1.00), but a low PPV (0.38, 95% CI 0.24-0.53). Conclusions: The MISS questionnaire can be used by researchers to rule out migraine history in stroke patients. To prevent misclassification, especially for the aura symptoms, patients with a positive screener should be interviewed more extensively to confirm the migraine diagnosis.

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Section: Discussioncontrasting

confidence: 88%

Section: Discussioncontrasting

confidence: 79%

Section: Methodsmentioning

confidence: 99%

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Assessment of Migraine History in Patients with a Transient Ischemic Attack or Stroke; Validation of a Migraine Screener for Stroke

Willik

Pelzer²,

Algra³

et al. 2016

Eur Neurol

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“…The LUMINA database includes over 54,000 adult migraine patients [9]. Of all the patients in this database, 87% has been diagnosed as migraine patient by a physician and 13% were self-reported migraineurs Of all patients 70% uses triptans.…”

Section: Methodsmentioning

confidence: 99%

What Do Patients Consider to Be the Most Important Outcomes for Effectiveness Studies on Migraine Treatment? Results of a Delphi Study

et al. 2014

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BackgroundThe outcome measures most frequently used in studies on the effectiveness of migraine treatment are whether the patient is free of pain, nausea, and free of photophobia/phonophobia within two hours. However, no patient-centred outcome measures are available. Therefore, we performed an online Delphi procedure to compile a list of outcome measures deemed most important to migraine patients.MethodsFrom a large database of migraine patients, we randomly selected 150 males and 150 females patients. We asked the open-ended question: ‘If a new medicine was developed for migraine attacks, what would you wish the effect of this medication to be?’ In the second and third rounds, we presented the answers of the first round and asked the patients to rate the importance of each item.ResultsThe initial response rate was 56% (n = 169). In the subsequent rounds the response rates were 90% (n = 152), and 97% (n = 147), respectively. Patients wanted their attack medication to treat the headache within 30 min, to prevent the attack from getting worse, to ensure they could function properly within 1 h, and prevent the recurrence of symptoms during the same day.ConclusionsThe currently used outcome measures in migraine research do not sufficiently reflect the wishes of patients. Patients want the medication to work faster, to take away pain at an earlier stage, to make them able to function properly quickly, and to prevent recurrence. These aspects should be considered in future evaluation of new attack medication for migraine.

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“…Our study was conducted as a part of the LUMINA project [15]. Participants were Dutch adults aged 18-74 years of age, both migraine patients and healthy controls.…”

Section: Subjectsmentioning

confidence: 99%

Restless legs syndrome in migraine patients: prevalence and severity

Oosterhout

Someren

Louter

et al. 2016

Euro J of Neurology

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Validation of the web-based LUMINA questionnaire for recruiting large cohorts of migraineurs

Abstract: This questionnaire is accurate and reliable in diagnosing migraine aura among self-reported migraineurs and enables detection of more aura cases with low false-positive rate.

Cited by 59 publications

References 25 publications

Assessment of Migraine History in Patients with a Transient Ischemic Attack or Stroke; Validation of a Migraine Screener for Stroke

Assessment of Migraine History in Patients with a Transient Ischemic Attack or Stroke; Validation of a Migraine Screener for Stroke

What Do Patients Consider to Be the Most Important Outcomes for Effectiveness Studies on Migraine Treatment? Results of a Delphi Study

Restless legs syndrome in migraine patients: prevalence and severity

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