Validation of Thromboelastometry in Cattle

Falco, Sara; Bruno, Barbara; Borrelli, Antonio; Cagnasso, Aurelio; D’Angelo, Antonio

doi:10.1007/978-3-642-23271-8_15

Cited by 6 publications

(13 citation statements)

References 10 publications

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“…Low values of alpha angle ( o ) indicate hypocoagulation of blood and high values indicate hypercoagulation. Values of the alpha angle found in our study were slightly higher than those reported for cattle and calves (Falco et al 2011, Borrelli et al 2013), but there were no inter-assay differences, which suggests a lack of disorders associated with the treatments carried out.…”

Section: Discussioncontrasting

confidence: 71%

“…There were no significant differences between MCF in all goats, but the values were clearly higher than those reported for cattle (Falco et al 2011). MCF is determined by platelet quality and count, fibrinogen level, fibrin polymerization, factor XIII and fibrinolysis.…”

Section: Discussioncontrasting

confidence: 60%

“…All thromboelastometric tests (INTEM, EXTEM, FIBTEM) carried out in goats before the surgical procedure demonstrated shorter CT than that reported for cattle (Falco et al 2011). No significant differences were found between coagulation times measured before and after the procedure, regardless of the type of dressing used (QickClot gauze or Celox gauze).…”

Section: Discussionmentioning

confidence: 68%

“…Comparative analysis demonstrated that CFT in goats is clearly shorter than in cattle (Falco et al 2011). Major factors affecting CFT are the contribution of platelets in clot formation, fibrinogen level and fibrin polymerization.…”

Section: Discussionmentioning

confidence: 93%

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Thromboelastographic profile of goat blood after the experimental injury of the femoral artery and use of QuikClot gauze and Celox gauze dressings

Sobiech

Adamiak

Holak

et al. 2017

Polish Journal of Veterinary Sciences

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The aim of this study was to evaluate the suitability of thromboelastometry for the analysis of blood test results in goats after the use of hemostatic dressings to control massive bleeding. The study was carried out on 12 goats, 6 animals in each of two subgroups. In all experimental animals incision of the femoral artery was performed, and bleeding was controlled with QuikClot gauze in the first group and Celox gauze in the second group. Dressings were applied for 60 minutes. Blood samples for thromboelastometry were collected from the jugular vein before the incision and 60 min after the application of a dressing. Clotting time (CT), clot formation time (CFT), maximum clot firmness (MCF) and α angle ( o ) were measured in three standard ROTEM assays (system with generation of reaction curve, numerical parameters and size of the blood clot): intrinsic coagulation pathway (INTEM), extrinsic coagulation pathway (EXTEM) and functional fibrinogen (FIBTEM). Complete hemostasis of the injured femoral artery was found in all goats. No significant differences between pre-and post-incision thromboelastometric parameters were found in any tests in any of the groups, which indicates that the use of dressings was not associated with blood coagulation disorders. This study is the first to describe the use of thromboelastometry in goats for the assessment of clot formation and hemostatic disorders.

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Section: Discussioncontrasting

confidence: 71%

Section: Discussioncontrasting

confidence: 60%

Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 93%

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Thromboelastographic profile of goat blood after the experimental injury of the femoral artery and use of QuikClot gauze and Celox gauze dressings

Sobiech

Adamiak

Holak

et al. 2017

Polish Journal of Veterinary Sciences

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“…In bovine medicine, only one preliminary study on thromboelastometry [32] has been published to date. In this study the analytical performance of the instrument in the bovine species has been evaluated and coefficients of variation have been calculated.…”

Section: Discussionmentioning

confidence: 99%

Thromboelastometry in veal calves to detect hemostatic variations caused by low doses of dexamethasone treatment

et al. 2013

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BackgroundThe illegal administration of hormones, steroids, β-agonists and other anabolic agents to productive livestock in the European Union continues, despite the long-term ban on their use and despite the measures provided under the directives to monitor certain substances and residues thereof in the interest of protecting consumer health and animal wellbeing. Often administered in low doses in the form of a drug cocktail, these compounds escape detection by common analytical techniques. The aim of this study was to determine whether low-dose dexamethasone administration (0.4 mg orally per day, for 20 days) in white-meat calves produced variations in blood coagulation, as measured by thromboelastometry. A second aim was to determine whether such variations could be valid in detecting illicit low-dose dexamethasone treatment.ResultsThe study population was 42 Friesian calves kept under controlled conditions until 6 months of age. The calves were subdivided into 2 groups: a control group (group A, n = 28) and a group treated with dexamethasone (group B, n = 14) for 20 days beginning at 5 months of age. When compared against the age-matched control group, the dexamethasone-treated calves showed a significant increase in alpha angle, maximum clot firmness and a significant decrease in clot formation time on all thromboelastometric profiles (P < 0.05). The clotting time was significantly decreased on the in-TEM® profile but increased on the ex-TEM® and fib-TEM® profiles (P <0.05). The Receiver Operating Characteristic curves, plotted for the Maximum Clot Elasticity (MCE), had a cut-off value ≥488.23 mm for in-TEM® MCE [Se 85.7%, (95% CI 57.2-98.2); Sp 100% 96.43% (95% CI 81.7-99.9] and a cut-off value ≥63.94 mm for fib-TEM® MCE [Se 92.8 (95% CI 66.1-99.8); Sp 89.3% (95% CI 71.8-97.7)]. In order to increase the sensitivity of the test two parameters (in-TEM® and fib-TEM® MCE) were used as two parallel tests; subsequently, the sensitivity rose to a point value of 99% (95% CI 85.4-99.9).ConclusionsThromboelastometry identified a state of hypercoagulability in the dexamethasone-treated subjects. Furthemore, the results of this preliminary study suggest that TEM may be useful in the detection of illicit low-dose dexamethasone treatment.

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Assessment of method reliability and determination of reference intervals for rotational thromboelastometry in horses

Junge

Ringer

Mayer

et al. 2016

J Vet Emergen Crit Care

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Validation of Thromboelastometry in Cattle

Cited by 6 publications

References 10 publications

Thromboelastographic profile of goat blood after the experimental injury of the femoral artery and use of QuikClot gauze and Celox gauze dressings

Thromboelastographic profile of goat blood after the experimental injury of the femoral artery and use of QuikClot gauze and Celox gauze dressings

Thromboelastometry in veal calves to detect hemostatic variations caused by low doses of dexamethasone treatment

Assessment of method reliability and determination of reference intervals for rotational thromboelastometry in horses

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