Validation protocol for whole-body dosimetry in an agricultural exposure study

Lee, Jiho; Kim, Eunhye; Shin, Yongho; Lee, Jong-Hwa; Lee, Junghak; Maasfeld, Wolfgang; Kim, Jeong‐Han

doi:10.1007/s13765-017-0330-8

Cited by 5 publications

(18 citation statements)

References 19 publications

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“…3), indicating that the matrixmatched standard solution should be used in LC-MS/MS analysis. 5,6 Recovery tests of chlorantraniliprole from various sample matrices were conducted, and the results ranged from 82% to 119% (CV < 4.9%), suggesting that the efficiency of acetonitrile extraction is reproducible (Table S7). Previous pesticide exposure studies showed similar results.…”

Section: Methods Validationmentioning

confidence: 99%

“…After 4 h, the fiberglass filter and solid sorbent were extracted and injected into the LC-MS/MS. 5,28 2.12 Field recovery test An aliquot of the standard solution (100 MLOQ) was added to the control matrix and stored under the same field temperature, humidity and working conditions. These samples, the matrices that were derived during the field trial, were extracted as explained in Section 2.4.…”

Section: Breakthrough Testsmentioning

confidence: 99%

“…This dermal exposure is in the range of 0.001-0.59%, as determined in previous research. 4,6,9,[34][35][36][37][38] In the case of mixing/loading and application, the exposure distribution of 11 body parts was evaluated by sampling the 11 pieces of outer and inner clothes. 5,6 The hand showed higher exposure (0.5 mg, 90.4% of total dermal exposure) than other body parts (Table 1; Fig.…”

Section: Exposure Characteristics During Mixing and Loadingmentioning

confidence: 99%

“…The level of exposure is affected by several factors including: the properties of the compound; working time; pesticide formulation; working type; spraying behavior of the workers; nature of the spraying equipment; and climatic conditions, such as temperature, wind speed/direction, and humidity during pesticide application. [4][5][6] In several studies that estimated the exposure of individual workers to pesticides, agricultural workers performed various roles, such as mixer/loader and applicator in paddy fields, wheat fields, glasshouses and orchards. [4][5][6][7][8] Agricultural workers are susceptible to pesticide exposure during the preparation of spray suspensions and their application to crops, and the major routes of exposure are through dermal deposition and inhalation.…”

Section: Introductionmentioning

confidence: 99%

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Potential exposure and risk assessment of agricultural workers to the insecticide chlorantraniliprole in rice paddies

Lee

Jung

et al. 2022

Pest Management Science

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BACKGROUND Exposure of agricultural workers in rice paddies to the insecticide chlorantraniliprole and its subsequent potential health risks were investigated during two scenarios (mixing/loading and hand‐held spraying). The exposure factors, such as the outer dosimeter, inner dosimeter, gauze, and nitrile gloves, were calculated using whole‐body dosimetry to measure dermal exposure. The inhalation exposure was determined using a fiberglass filter which is set with an Institute of Occupational Medicine (IOM) sampler. A recovery test was performed to evaluate the accuracy of the analytical method. RESULTS The exposure amounts of various matrices were calculated from extraction volume and concentration of the target compound. The dermal exposure to chlorantraniliprole was 0.6 mg [0.001% of the total active ingredient (a.i.)] for mixing and loading, and 28.6 mg (0.066% of the total a.i.) for application. The inhalation exposure to chlorantraniliprole was 7.2 μg (1.3%, 1.2 × 10−5% of the total applied a.i.) for mixing and loading, and 1.9 μg (0.006%, 4.4 × 10−6% of the total applied a.i.) for application. The most exposed part of the body was the hand (90.4%) during mixing and loading, whereas the primary sites during application were the thighs (32.8%) and shins (22.6%). For mixing and loading, the amount of actual dermal exposure was 5.5 μg day−1 and that of actual inhalation exposure was 21.9 μg day−1. By contrast, in the application, the amounts of actual dermal and actual inhalation exposures were 34 178.7 and 5.9 μg day−1, respectively. CONCLUSIONS The risk assessment results demonstrated that the risk of chlorantraniliprole exposure in rice paddies was low during application than during mixing and loading. © 2022 Society of Chemical Industry.

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Section: Methods Validationmentioning

confidence: 99%

Section: Breakthrough Testsmentioning

confidence: 99%

Section: Exposure Characteristics During Mixing and Loadingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Potential exposure and risk assessment of agricultural workers to the insecticide chlorantraniliprole in rice paddies

Lee

Jung

et al. 2022

Pest Management Science

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“…Instrumental repeatability is a parameter that ensures the integrity of instrumental performance for target compounds [14,15]. A repeatability test was conducted by consecutively injecting matrix-matched standard solutions at 0.01 and 0.05 mg/L (n = 7, respectively), and the area RSD was verified for each pesticide.…”

Section: Instrumental Repeatabilitymentioning

confidence: 99%

A simultaneous multiresidue analysis for 203 pesticides in soybean using florisil solid-phase extraction and gas chromatography–tandem mass spectrometry

2018

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A multiresidue analysis method for the simultaneous determination of 203 pesticides in soybean was developed using solid-phase extraction (SPE) and gas chromatography-tandem mass spectrometry (GC-MS/ MS). Scheduled multiple reaction monitoring by GC-MS/ MS was optimized in electron ionization mode. The target pesticides satisfied the method limit of quantitation below 0.01 mg/kg, and an excellent instrumental repeatability was obtained. The calibration curve correlation coefficients (r 2) for 201 (99.0%) pesticides were C 0.990. The Multiclass Pesticide Multiresidue Method (No. 2) of the Korea Food Code was scaled down and applied for efficient sample treatment. Soybean sample (10 g) was extracted with 20 mL acetonitrile. The sample was filtered, partitioned with sodium chloride, and centrifuged. The supernatant (8 mL) was subjected to cleanup with a florisil SPE cartridge (500 mg), and the final extract was subjected to GC-MS/MS analysis. To remove fat, further liquid-liquid partitioning with n-hexane/acetonitrile was conducted before the SPE cleanup, and this procedure was compared to the non-partitioning procedure. The percentage of pesticides satisfying the recovery range of 70-120% with a relative standard deviation B 20% in the non-partitioning and partitioning procedures were 87.2% and 78.8% at 0.01 mg/kg and 88.2% and 76.8% at 0.05 mg/kg, respectively. The average matrix effect value (%) was 5.5%. This miniaturized analytical method can be successfully applied for rapid and sensitive monitoring of multiresidues in soybean and related agricultural products.

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Occupational exposure and risk assessment for agricultural workers of thiamethoxam in vineyards

Lee

Kim

Shin

et al. 2022

Ecotoxicology and Environmental Safety

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Validation protocol for whole-body dosimetry in an agricultural exposure study

Cited by 5 publications

References 19 publications

Potential exposure and risk assessment of agricultural workers to the insecticide chlorantraniliprole in rice paddies

Potential exposure and risk assessment of agricultural workers to the insecticide chlorantraniliprole in rice paddies

A simultaneous multiresidue analysis for 203 pesticides in soybean using florisil solid-phase extraction and gas chromatography–tandem mass spectrometry

Occupational exposure and risk assessment for agricultural workers of thiamethoxam in vineyards

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