Validation study of a pooled electronic healthcare database: the effect of obesity on the revision rate of total knee arthroplasty

Pfefferle, Kiel J.; Gil, Karen M.; Fening, Stephen D.; Dilisio, Matthew F.

doi:10.1007/s00590-014-1423-2

Cited by 40 publications

(21 citation statements)

References 5 publications

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“…If validated for use, such a large cohort provides a potentially rich archive for investigation into diseases of low prevalence. This study substantiates the external validation of the EPM database from previous studies, [14][15][16] clearing the way for the EPM database to be used to test other hypotheses in the MS population.…”

Section: Discussionsupporting

confidence: 84%

“…Explorys Enterprise Performance Management (EPM) is a Health Insurance Portability and Accountability Act-compliant database containing de-identified clinical data for 50 million patients. 13 It has been externally validated in large retrospective studies characterizing venous thromboembolic events, 14 the effect of obesity on total knee arthroplasty, 15 and secondary malignancies. 16 We aimed to use the EPM database as a novel approach to assessing the association between the use of DMTs, including interferon, and depression in the MS population, comparing the results with those from the 2008 study by Patten et al 12 …”

Section: Study Populationmentioning

confidence: 99%

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Antidepressant Drug Treatment in Association with Multiple Sclerosis Disease-Modifying Therapy

Mirsky¹,

Marrie²,

Rae-Grant³

2016

International Journal of MS Care

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Section: Discussionsupporting

confidence: 84%

Section: Study Populationmentioning

confidence: 99%

Antidepressant Drug Treatment in Association with Multiple Sclerosis Disease-Modifying Therapy

Mirsky¹,

Marrie²,

Rae-Grant³

2016

International Journal of MS Care

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“…The database rounds number of patients to the nearest 10 for an added data protection. This platform has been used for research purposes and has been validated in fields of oncology 23 , orthopedics 24 , gastroenterology 25 , gynecology 26 among others.…”

Section: Methodsmentioning

confidence: 99%

Brief Report: Elevated Red Cell Distribution Width Identifies Elevated Cardiovascular Disease Risk in Patients With HIV Infection

Al‐Kindi

Kim

Morris

et al. 2017

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Red cell distribution width (RDW) is linked to cardiovascular risk in the general population, an association that might be driven by inflammation. Whether this relationship holds for patients with Human Immunodeficiency Virus (HIV) infection has not been previously studied. Using a large clinical registry, we show that elevated RDW (>14.5%) is independently associated with increased risk of coronary artery disease (odds ratio (OR) 1.39 [1.25–1.55]), peripheral vascular disease (OR 1.41 [1.29–1.53]), myocardial infarction (1.43 [1.25–1.63]), heart failure (OR 2.23 [1.99–2.49]), and atrial fibrillation (OR 1.96 [1.64–2.33]). In conclusion, in the context of the inflammatory milieu that accompanies HIV infection, RDW remains a powerful marker of CV disease.

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“…The database rounds number of patients to the nearest 10 for an added data protection. This platform has been used for research purposes and has been validated in fields of orthopedics[6], hematology[7], surgery[8], gastroenterology[5], gynecology[9] among others.…”

Section: Methodsmentioning

confidence: 99%

Heart failure in patients with human immunodeficiency virus infection: Epidemiology and management disparities

Al‐Kindi

ElAmm

Ginwalla

et al. 2016

International Journal of Cardiology

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Background Persons living with HIV are at a higher risk of cardiovascular disease despite effective antiretroviral therapy and dramatic reductions in AIDS-related conditions. We sought to identify the epidemiology of heart failure (HF) among persons living with HIV in the United States in an era of contemporary antiretroviral therapy. Methods Explorys is an electronic healthcare database that aggregates medical records from 23 healthcare systems nationwide. Using systemized nomenclature of medicine - clinical terms (SNOMED-CT), we identified adult patients (age > 18), who had active records over the past year (September 2014–September 2015). We described the prevalence of HF in HIV patients by demographics and treatment and compared them to HIV-uninfected controls. Results Overall, there were 36,400 patients with HIV and 12,208,430 controls. The overall prevalence of HF was 7.2% in HIV and 4.4% in controls (RR 1.66 [1.60–1.72], p<0.0001). The relative risk of HF associated with HIV infection was higher among women and younger age groups. Patients receiving antiretroviral therapy had only marginally lower risk (6.4% vs 7.7%, p<0.0001) of HF compared to those who were untreated. Compared to uninfected patients with HF, HIV patients with HF were less likely to receive antiplatelet drugs, statins, diuretics, and ACE/ARBs (p<0.0001 for all comparisons). For patients with HIV and HF, receiving care from a cardiologist was associated with higher use of antiplatelets, statins, betablockers, ACE/ARBs, and diuretics. Conclusions Persons with HIV are at higher risk for HF in this large contemporary sample that includes both men and women. Although the prevalence of heart failure is higher in older HIV patients, the relative risk associated with HIV is highest in young people and in women. HIV patients are less likely to have HF optimally treated, but cardiology referral was associated with higher treatment rates.

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Validation study of a pooled electronic healthcare database: the effect of obesity on the revision rate of total knee arthroplasty

Cited by 40 publications

References 5 publications

Antidepressant Drug Treatment in Association with Multiple Sclerosis Disease-Modifying Therapy

Antidepressant Drug Treatment in Association with Multiple Sclerosis Disease-Modifying Therapy

Brief Report: Elevated Red Cell Distribution Width Identifies Elevated Cardiovascular Disease Risk in Patients With HIV Infection

Heart failure in patients with human immunodeficiency virus infection: Epidemiology and management disparities

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