Validity of a model using routinely collected data for identifying infections following gastric, colon, and liver cancer surgeries

Yamana, Hayato; Tsuchiya, Asuka; Horiguchi, Hiromasa; Morita, Shigeki; Kuroki, Tamotsu; Nakai, Kenta; Nishimura, Hideo; Jo, Taisuke; Fushimi, Kiyohide; Yasunaga, Hideo

doi:10.1002/pds.5386

Cited by 10 publications

(14 citation statements)

References 32 publications

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“…Full‐text articles of 42 studies were retrieved, and six were excluded because they compared aggregate data, validated self‐report questionnaires using claims data as a reference standard, were review articles, were aimed at refining the cancer registry and not for research purposes, did not report case‐defining methods, or did not report a reference standard 12,19–23 . There were 36 eligible studies, including 29 studies 8,10,11,13,24–48 that validated administrative data using an external reference standard and seven studies 9,49–54 that validated administrative data using other data within the same database.…”

Section: Resultsmentioning

confidence: 99%

“…We also found studies that evaluated clinical conditions, such as gastrointestinal perforation, febrile neutropenia, and postoperative infection. 27,39,45 A study on dental claims assessed the validity of procedures, number of teeth, and time of anesthesia. 42 Another study published after our search period also validated operative information.…”

Section: Discussionmentioning

confidence: 99%

“…These challenges may be especially relevant for large-scale, multi-center validation studies. Notably, our review found several studies 13,28,29,34,43,45,47,49 by the National Hospital Organization, 56 Japanese Registry of all Cardiac and Vascular Diseases, 57 Tokushukai Medical Group, 58 and Medical Information Database Network. 59 Most of the current studies were conducted in small portion of institutions belonging to each group.…”

Section: Discussionmentioning

confidence: 99%

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Validation studies of Japanese administrative health care data: A scoping review

Yamana

Konishi

Yasunaga

2023

Pharmacoepidemiology and Drug

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Purpose Large‐scale administrative health care databases are increasingly being utilized for research. However, there has not been much literature that validated administrative data in Japan; a previous review identified six validation studies published between 2011 and 2017. We conducted a literature review of studies that assessed the validity of Japanese administrative health care data. Methods We searched for studies published by March 2022 that compared individual‐level administrative data with a reference standard from another data source, as well as studies that validated administrative data using other data within the same database. The eligible studies were also summarized based on characteristics which included data types, settings, reference standard used, numbers of patients, and conditions validated. Results There were 36 eligible studies, including 29 that used external reference standard and seven that validated administrative data using other data within the same database. Chart review was the reference standard in 21 studies (range of the numbers of patients, 72–1674; 11 studies conducted in single institutions and nine studies in 2–5 institutions). Five studies used a disease registry as the reference standard. Diagnoses of cardiovascular diseases, cancer, and diabetes were frequently evaluated. Conclusions Validation studies are being conducted at an increasing rate in Japan, although most of them are small scale. Further large‐scale comprehensive validation studies are necessary to effectively utilize the databases for research.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Validation studies of Japanese administrative health care data: A scoping review

Yamana

Konishi

Yasunaga

2023

Pharmacoepidemiology and Drug

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“…The discharge summary for each patient is coded by the attending physicians. Previous validation studies have shown that this database possesses highly accurate data on patients with esophageal cancer, 20 surgical procedures including oncologic esophagectomy, 21 comorbidities, 22 and postoperative complications 23 …”

Section: Methodsmentioning

confidence: 99%

Antimicrobial Prophylaxis with Ampicillin-sulbactam Compared with Cefazolin for Esophagectomy

Hirano,

Konishi,

Kaneko

et al. 2023

Annals of Surgery

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Objective: To assess the effect of antimicrobial prophylaxis with ampicillin-sulbactam (ABPC/SBT) compared with cefazolin (CEZ) on the short-term outcomes after esophagectomy. Summary Background Data: CEZ is widely used for antimicrobial prophylaxis in esophagectomy without procedure-specific evidence, whereas ABPC/SBT is preferred in some hospitals to target both aerobic and anaerobic oral bacteria. Methods: Data of patients who underwent esophagectomy for cancer between July 2010 and March 2019 were extracted from a nationwide Japanese inpatient database. Overlap propensity score weighting was conducted to compare the short-term outcomes [including surgical site infection (SSI), anastomotic leakage, and respiratory failure] between antimicrobial prophylaxis with CEZ and ABPC/SBT, after adjusting for potential confounders. Sensitivity analyses were also performed using propensity score matching and instrumental variable analyses. Results: Among 17,772 eligible patients, 16,077 (90.5%) and 1695 (9.5%) patients were administered CEZ and ABPC/SBT, respectively. SSI, anastomotic leakage, and respiratory failure occurred in 2971 (16.7%), 2604 (14.7%), and 2754 patients (15.5%), respectively. After overlap weighting, ABPC/SBT was significantly associated with a reduction in SSI [odds ratio 0.51 (95% confidence interval 0.43–0.60)], anastomotic leakage [0.51 (0.43–0.61)], and respiratory failure [0.66 (0.57–0.77)]. ABPC/SBT was also associated with reduced respiratory complications, postoperative length of stay, and total hospitalization costs. The proportion of Clostridioides difficile colitis and noninfectious complications did not differ between the groups. Propensity score matching and instrumental variable analyses demonstrated equivalent results. Conclusions: The administration of ABPC/SBT as antimicrobial prophylaxis for esophagectomy was associated with better short-term postoperative outcomes compared to CEZ.

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“…Most recently, developing regression model-based event detection and validation could identify postsurgical infections from the routinely-collected DPC data in the NHO database on a cut-off score with C-statistic of 0.885, sensitivity of 92% and specificity of 72%, and on another cut-off score with sensitivity of 75% and specificity of 91%. 23 …”

Section: Data Resource Usementioning

confidence: 99%

Existing Data Sources for Clinical Epidemiology: Database of the National Hospital Organization in Japan

Kanazawa¹,

Tani²,

Imai³

et al. 2022

CLEP

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This review introduces the National Hospital Organization (NHO) database in Japan. The NHO has maintained two databases through a system of data collection from 140 hospitals in the NHO. National Hospital Organization Clinical Data Archives (NCDA) is collecting clinical information in real time from the electronic medical records since January 2016, and Medical Information Analysis (MIA) databank is collecting daily insurance claims data since April 2010. The NHO database covers more than 8 million patients in 140 hospitals throughout Japan. The database consists of the information of patient profiles, hospital admission and discharge, diagnosis with ICD-10 codes, text data from medical chart, daily health insurance claims such as medical procedures, medications or surgeries, vital signs and laboratory data, and so on. The NHO database includes a wide variety of diseases and settings, including acute, chronic and intractable diseases, emergency medical services, disaster medicine, response to emerging infectious disease outbreaks, medical care according to health policies such as psychiatry, tuberculosis, or muscular dystrophy, and health systems in sparsely populated non-urban areas. Among several common diseases, the database has representativeness in terms of age distribution compared with the Patient Survey 2017 by the Ministry of Health, Labour and Welfare. Interested researchers can contact (700-dbproject@mail.hosp.go.jp) the NHO database division to obtain more information about the NHO database for utilization.

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Validity of a model using routinely collected data for identifying infections following gastric, colon, and liver cancer surgeries

Cited by 10 publications

References 32 publications

Validation studies of Japanese administrative health care data: A scoping review

Validation studies of Japanese administrative health care data: A scoping review

Antimicrobial Prophylaxis with Ampicillin-sulbactam Compared with Cefazolin for Esophagectomy

Existing Data Sources for Clinical Epidemiology: Database of the National Hospital Organization in Japan

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