Validity of image-defined risk factors in localized neuroblastoma: A report from two centers in Western Japan

Fumino, Shigehisa; Kimura, Koseki; Iehara, Tomoko; Nishimura, Motoki; Nakamura, Satoaki; Souzaki, Ryota; Nishie, Akihiro; Taguchi, Tomoaki; Hosoi, Hajime; Tajiri, Tatsuro

doi:10.1016/j.jpedsurg.2015.08.039

Cited by 14 publications

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References 7 publications

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“…Tumors can metastasize either via the lymphatic or the hematogenous systems. A tumor that has spread to the ganglia outside the cavity of origin still represents a metastatic lesion [ 20 ]. A study from the Vanderbilt University Medical Center in Nashville proved that up to 50% of neuroblastomas spread to lymph nodes, a value which is similar to our findings (n = 15, 48.38%) [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some authors recommend neoadjuvant chemotherapy in the presence of IDRFs [ 43 ]. The presence of IDRFs can predict the extent of the surgery, and it should be integrated as part of the treatment plan, but it is probably best used in association with other prognosis factors, such as MYCN amplification, NSE level, tumor size, and histological characteristics [ 20 , 21 , 42 , 44 , 45 , 46 ]. Our results are similar to a systematic review of 3725 studies that concluded that IDRF-positive neuroblastomas have a higher risk of incomplete surgical resection and a higher risk of 5-year mortality or relapse [ 47 ].…”

Section: Discussionmentioning

confidence: 99%

“…The association of positive IDRFs at the time of initial diagnosis with poor outcome is a subject of controversy, with many authors suggesting that the IDRF status could change after chemotherapy, and as such, a new evaluation should be performed right before surgery, as it may have a different prognosis [ 19 , 20 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of Image-Defined Risk Factors with Clinical, Biological Features and Outcome in Neuroblastoma

et al. 2022

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Background: Neuroblastoma (NB) is the most common pediatric extracranial solid tumor and the most common cancer encountered in children younger than 12 months of age. Localized tumors have a good prognosis, but some cases undergo treatment failure and recurrence. The aim of the study was to analyze the link between the neuroblastoma risk factors and the prognosis for patients diagnosed with NB. Method: All patients admitted to the department of Pediatric Surgery, “Grigore Alexandrescu” Clinical Emergency Hospital for Children, between 1 January 2010 and 1 July 2022 were included in this analysis when diagnosed with neuroblastoma. Results: Thirty-one patients with NB were admitted to the surgical department, 20 boys and 11 girls. We observed an association between large tumors and positive imaging-defined risk factor (IDRF) status; The Fisher test showed an association between the tumor’s diameter when bigger than 8 cm and a positive IDRF status, with p < 0.001. We supposed that positive IDRF status at diagnosis may be linked to other prognostic factors. We discovered that an NSE value over 300 was associated with IDRF status (p < 0.001, phi = 0.692) and death. Conclusions: This study confirms the impact of IDRF status at diagnosis as it can be clearly correlated with other risk factors, such as a high level of NSE, MYCN amplification status, large tumor size, incomplete tumor resection, and an unfavorable outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Association of Image-Defined Risk Factors with Clinical, Biological Features and Outcome in Neuroblastoma

et al. 2022

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“…Для артерии -опухоль охватывает не более 50 % окружности сосуда к ее окружности, для описания вены -при уменьшении диаметра сосуда просвет ее остается доступным для визуализации [29,30]. В исследовании S. Fumino (2015) ретроспективно было установлено, что внесение дополнения о включении прямого контакта с почечной ножкой как фактора риска снизило количество незапланирован-ных нефрэктомий и в целом благоприятно повлияло на прогноз пациентов с НБ, но при этом привело к увеличению числа больных с выявленными абдоминальными факторами риска с 39,5 до 81,6 % [31]. При анализе распространенности факторов риска, так как наиболее частой локализацией НБ являются брюшная полость и забрюшинное пространство, именно в данной анатомической области и выявляются факторы риска группы F, представленные на рис.…”

Section: наличие жировой ткани между опухолью и жизненно важными струunclassified

Image defined risk factors in patients with neuroblastoma. Literature review

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Шаманская

et al. 2019

Ross. ž. det. gematol. onkol.

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Currently, two staging systems are used: the International Neuroblastoma Staging System (INSS), which relies on surgical staging, and the International Neroblastoma Risk Group Stading System (INRGSS), which relies on preoperative imaging for staging and image-defined risk. The article presents a review of the literature on image defined risk factors (IDRF) determined during radiological studies (computed tomography and magnetic resonance imaging) in patients with neuroblastoma. The article focuses on the definition of IDRFs, their prevalence and their influence on surgical outcomes and prognosis of patients with neuroblastoma.

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“…Simon et al found that the presence of IDRFs did not indicate unresectability and could not improve the predicted outcome of localized neuroblastoma [6]. Fumino et al also proposed that IDRFs may overestimate the surgical risks, leading to unnecessary chemotherapy and prolonged stay in hospital [8].…”

Section: Introductionmentioning

confidence: 99%

Role of image-defined risk factors in predicting surgical complications of localized neuroblastoma

Liu

et al. 2020

Pediatr Surg Int

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Purpose To explore the relationship between image-defined risk factors and surgical complications of localized neuroblastoma. Methods We retrospectively evaluated 84 patients who met the inclusion criteria at our hospitals between June 2014 and June 2019. Patients' clinic data were collected and the common terminology criteria for adverse events were used to categorize complications as major (grade 3-4) or minor (grade 1-2). Results Four (11.8%) out of 34 stage L1 patients and 15 (30.0%) out of 50 stage L2 patients had surgical complications (P < 0.05). Seventy patents underwent primary surgery, including all stage L1 patients and 36 stage L2 patients. There were no significant differences between the two groups regarding surgical complications or major surgical complications. Among stage L2 patients, 2 (5.6%) out of 36 who underwent primary surgery and 2 (14.3%) out of 14 who underwent secondary surgery had major surgical complications (P < 0.05). Complete tumor resection was achieved in 18 (50%) and 7 (50%) patients in each group (P > 0.05). The mean numbers of IDRFs were 2.06 and 4.29, respectively (P < 0.05). Conclusions Localized neuroblastoma patients with IDRFs have a greater surgical risk. And the number of IDRFs is not ignorable, especially in predicting major surgical complications.

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Validity of image-defined risk factors in localized neuroblastoma: A report from two centers in Western Japan

Cited by 14 publications

References 7 publications

Association of Image-Defined Risk Factors with Clinical, Biological Features and Outcome in Neuroblastoma

Association of Image-Defined Risk Factors with Clinical, Biological Features and Outcome in Neuroblastoma

Image defined risk factors in patients with neuroblastoma. Literature review

Role of image-defined risk factors in predicting surgical complications of localized neuroblastoma

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