Validity of Simpson-Angus Scale (SAS) in a naturalistic schizophrenia population

Janno, Sven; Holi, Matti; Tuisku, Katinka; Wahlbeck, Kristian

doi:10.1186/1471-2377-5-5

Cited by 93 publications

(70 citation statements)

References 21 publications

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“…It further ignores subjective symptomatology. Recent work suggests that the Simpson-Angus is reliable but the traditional cut-off (0.3) is far too low, thus compromising specificity (Janno et al, 2005), a crucial point in interpretation. LOCF Analysis of data using 'last observation carried forward' (LOCF) is the standard statistical method to which data from all trials of new drugs was subjected but, it is suggested, this may have contributed advantage to new antipsychotics (Rosenheck, 2005).…”

Section: Other Issuesmentioning

confidence: 99%

How CATIE brought us back to Kansas: a critical re-evaluation of the concept of atypical antipsychotics and their place in the treatment of schizophrenia

Owens¹

2008

Adv. psychiatr. treat

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The subdivision of the class of antipsychotic drugs into two discrete groups – ‘conventional’ (or first generation) and ‘atypical’ (or second generation) – has been adopted as standard, with the latter generally accepted as ‘better’ and widely recommended as automatic first-line choices. However, this perception has been thrown into confusion with the results of large pragmatic trials that failed to identify advantages with the new, more expensive drugs, while identifying worrying tolerability issues. This article explores the origins of ‘atypicality’, its construction on the back of a confusing and weak clinical validator (diminished liability to promote parkinsonism) and how even in relation to the archetypical atypical, clozapine, the uncertain boundaries of drug-induced extrapyramidal dysfunction may be contributing to confusion about ‘efficacy’ and ‘tolerability’. It argues that abandoning atypicality would open up clinical practice to all drugs of a single class of ‘antipsychotics’ and allow for individualised risk/benefit appraisal as a basis for truly tailored treatment recommendations.

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Section: Other Issuesmentioning

confidence: 99%

How CATIE brought us back to Kansas: a critical re-evaluation of the concept of atypical antipsychotics and their place in the treatment of schizophrenia

Owens¹

2008

Adv. psychiatr. treat

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“…In the evaluation, the scores for all items are summed up and divided by 10. With a score of 0.3 and above, a diagnosis of neuroleptic-induced Parkinsonism is made (28).…”

Section: Simpson-angus Scale (Sas)mentioning

confidence: 99%

Uzun süre antipsikotik tedavisi alan mental retardasyonlu hastalarda tardiv diskinezi

Can¹,

Nalbant²,

Burhan³

et al. 2016

Dusunen Adam

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Tardive dyskinesia in mentally retarded patients under long-term antipsychotic treatmentObjective: Tardive dyskinesia (TD) is an iatrogenic movement disorder, developing due to prolonged use of dopamine receptor blocking agents, that may affect various parts of the body. In a number of studies, prevalence rates between 5 and 30% have been reported. This study aims to research TD in patients with mental retardation who have been hospitalized for a long time and medicated regularly.Method: Included in this study were 40 patients with a diagnosis of mental retardation comorbid with schzophrenia or other psychotic disorders according to DSM-IV TR that had been hospitalized in the chronic patients' ward of Bakirkoy Training and Research Hospital for Psychiatry, Neurology and Neurosurgery for a long period. Duration and type of antipsychotics both at the time of interview and over the preceding years were recorded. Dyskinesia was assessed using the Abnormal Involuntary Movements Scale (AIMS). We also used the Simpson-Angus Rating Scale (SAS) for Parkinsonism. Akathisia was measured using the Barnes Akathisia Rating Scale (BARS).Results: According to AIMS scores, 9 participants (22.5%) received a diagnosis of TD. There was no significant correlation between the type and duration of ongoing or the longest used treatment and the prevalence of TD. There was a statistically significant correlation between the participants' age and TD (p=0.009). There were no gender differences for TD Conclusion: We found that long-term use of antipsychotics is unrelated with TD, while age is an important risk factor for TD. It can be said that switching from first generation to second generation antipsychotics does not reduce the prevalence of TD.Keywords: Antipsychotics, mental retardation, tardive dyskinesia ÖZET Uzun süre antipsikotik tedavisi alan mental retardasyonlu hastalarda tardif diskinezi Amaç: Tardif diskinezi (TD) uzun süreli dopamin reseptör blokajı oluşturan ilaçlara bağlı olarak gelişen, vücudun çeşitli bölgelerini tutabilen iatrojenik bir hareket bozukluğudur. Yapılan çalışmalarda prevalansının %5 ila %30 aralığında değiştiği görülmektedir. Bu araştırma, ruh sağlığı hastanesinde uzun süredir yatan ve düzenli olarak ilaç almakta olan mental retardasyonlu hastalarda tardiv diskineziyi araştırmayı amaçlamaktadır. Bulgular: AİHÖ puanlarına göre değerlendirildiğinde katılımcıların 9'una (%22.5) TD tanısı kondu. TD tanısı konanlarda geçmişte ya da halen kullanılan antipsikotik türü ve süresi ile TD arasında bir ilişki saptanmadı.Katılımcıların yaşlarıyla TD arasında istatistiksel olarak anlamlı ilişki bulundu (p=0.009). Kadınlarla erkekler arasında TD açısından fark saptanmadı.Sonuç: Araştırmamızda uzun süreli antipsikotik kullanımının TD ile ilişkisiz olduğu, yaşın ise TD riski açısından önemli bir etken olduğu saptanmıştır. Birinci kuşak antipsikotik tedaviden ikinci kuşağa geçmesinin ise TD sıklığını azaltmadığı söylenebilir.

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“…Antipsychotic side effect rating scales were first introduced in the 1970s. Since then a number of side effect and adverse effect scales have been developed [24,25].…”

Section: Introductionmentioning

confidence: 99%

“…A number of scales focus primary on EPS such as the Abnormal Involuntary Movement Scale (AIMS) [28], extra pyramidal Symptom Rating Scale (ESRS) [25], the Simpson-Angus Scale (SAS) [24] and the Udvalg for Kliniske Undersogelser Side-Effect Rating Scale (UKUSERS) [26].…”

Section: Introductionmentioning

confidence: 99%

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Validation of the Glasgow Antipsychotic Side-Effect Scale (GASS) in Greece

Nystazaki¹

2014

JPCPY

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The aim of the present study was to evaluate the linguistic adaptation and psychometric validation into the Greek language of the GASS scale for the assessment of side effects in patients treated with second generation antipsychotic medication. The GASS scale takes 5 minutes to complete (21 items for men and women) and contains self-explanatory questions in everyday plain English while providing a structured systematic method of reviewing antipsychotic side effects. The translation and cultural adaptation of the questionnaire was performed according to international standards. Internal consistency using the Cronbach α coefficient and test-retest reliability using the intraclass correlation coefficient (ICC) was used to assess the reliability of the instrument. Patient's sample consisted of 80 participants with a mean age of 42.6 years. Internal consistency and intraclass correlation coefficient were adequate (Cronbach α = 0.79 and ICC = 0.96). The test-retest percent agreement for the aforementioned categories was 95.9. Agreement was satisfactory according to Kappa coefficient which was equal to 0.78 (p<0.001).The Greek validation of the GASS scale shows appropriate feasibility, reliability, and discriminative performance as a patient-reported outcome to be used for the assessment of the impact of side effects on patients with schizophrenia.

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Validity of Simpson-Angus Scale (SAS) in a naturalistic schizophrenia population

Cited by 93 publications

References 21 publications

How CATIE brought us back to Kansas: a critical re-evaluation of the concept of atypical antipsychotics and their place in the treatment of schizophrenia

How CATIE brought us back to Kansas: a critical re-evaluation of the concept of atypical antipsychotics and their place in the treatment of schizophrenia

Uzun süre antipsikotik tedavisi alan mental retardasyonlu hastalarda tardiv diskinezi

Validation of the Glasgow Antipsychotic Side-Effect Scale (GASS) in Greece

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