Validity of the association between periodontitis and female infertility conditions: a concise review

Machado, Vanessa; Lopes, Joana; Patrão, Mariana; Proença, Luís; Mendes, José João

doi:10.1530/rep-20-0176

Cited by 20 publications

(13 citation statements)

References 167 publications

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“…Further, other factors such as seasonal variation [ 96 ], race and vitamin D binding protein [ 97 ] can also affect 25(OH)D levels. Likewise, periodontitis is also a relevant risk factor in these pathologies [ 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 ], and a potential mediation effect of periodontitis-vitamin D may be considered and further developed in clinical studies.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis

Machado

Lobo

Proença³

et al. 2020

Nutrients

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To explore the vitamin D levels of periodontitis patients in comparison with periodontally healthy ones, and to assess the influence of vitamin D supplementation as an adjunctive during nonsurgical periodontal treatment (NSPT). Five databases (Pubmed, Embase, Scholar, Web of Sciences, and Cochrane Library) were searched until May 2020. Mean difference (MD) meta-analysis with corresponding 95% confidence interval (95% CI) and sensitivity tests via meta-regression were used. We followed Strength of Recommendation Taxonomy (SORT) to appraise the strength and quality of the evidence. Sixteen articles were included, fourteen case-control and two intervention studies, all reporting 25-hydroxyvitamin D (25(OH)D) levels. Compared with the healthy controls, the circulating 25(OH)D levels were significantly lower in chronic periodontitis patients (pooled MD = −6.80, 95% CI: −10.59 to −3.02). Subgroup analysis revealed differences among 25(OH)D measurements, with liquid chromatography-mass spectrometry being the most homogeneous method (pooled MD = −2.05, 95% CI: −3.40 to −0.71). Salivary levels of 25(OH)D showed no differences between groups. Due to the low number of studies, conclusions on aggressive periodontitis and in the effect of vitamin D supplementation after NSPT were not possible to ascribe. Compared with healthy controls, 25(OH)D serum levels are significantly lower in chronic periodontitis patients, with an overall SORT A recommendation. Future studies are needed to clarify the effect of vitamin D supplementation and the biological mechanisms linking vitamin D to the periodontium.

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Section: Discussionmentioning

confidence: 99%

Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis

Machado

Lobo

Proença³

et al. 2020

Nutrients

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“…Recently, several possible associations were proposed to explain how PD acts as a modifiable risk factor in female infertility related conditions [ 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. Nevertheless, to the best of our knowledge, there is a lack of studies concerning the periodontal status of women seeking fertility treatment.…”

Section: Introductionmentioning

confidence: 99%

Comparisons of Periodontal Status between Females Referenced for Fertility Treatment and Fertile Counterparts: A Pilot Case–Control Study

Machado

Botelho

Proença³

et al. 2020

IJERPH

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Studies investigating the periodontal status of women seeking fertility treatment have never been conducted. The purpose of this pilot study was to compare the periodontal status among females referenced to a Fertility Clinic (FC) when compared to matched females from a representative regional epidemiological sample. Our secondary aims were to investigate if periodontal clinical measures differ between these two groups of females and how they impact on oral health-related quality of life (OHRQoL). We enrolled 18 women from an FC and 18 age, race and body mass index matched controls from the epidemiological survey Study of Periodontal Health in Almada-Seixal (SoPHiAS). In each subject, we performed a circumferential periodontal inspection to infer the periodontal status and applied a questionnaire measuring OHRQoL. FC females presented higher levels of periodontal disease, with higher periodontal epithelial surface area, periodontal probing depth and clinical attachment loss. However, periodontal diseases did not impact OHRQoL in this particular group of women seeking fertility care, suggesting unawareness about periodontal diseases. Within the limitations of this study, females referenced for fertility treatment presented worse periodontal measures than females from a representative control sample. These preliminary results may support future prospective studies to further explore the periodontal status and possible consequences in women seeking fertility care.

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“…PD and ED share risk factors such as age, obesity, smoking, diabetes mellitus, metabolic syndrome, hypertension, cardiovascular diseases, and excessive drinking (Machado et al, 2020; Zuo et al, 2011). Both, also share common pathophysiological pathways, including endothelial dysfunction and inflammation (Kulshrestha et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

The Association Between Periodontitis and Erectile Dysfunction: A Systematic Review and Meta-Analysis

et al. 2021

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The objective of this study is to investigate the association between periodontitis (PD) and erectile dysfunction (ED). A systematic review and meta-analysis on data was extracted and conducted according to PRISMA. Relevant articles were selected from a literature search using MEDLINE, EMBASE, Scopus, Web of Science and CENTRAL from inception until August 2, 2020. Both randomized and nonrandomized controlled studies were included. Case reports, case series, nonsystematic reviews and trials published as abstract were excluded. Odds ratios (ORs) and corresponding 95% conﬁdence intervals (CIs) were used to estimate the association between PD and the risk of ED. The meta-analysis was conducted with RevMan 5.3. Methodological quality assessment was carried out using the Newcastle-Ottawa Quality Assessment Scale and the quality of evidence was assessed using the GRADE approach. Six articles (215008 subjects) were included for analysis. Of the participants, 38,675 cases were compared to 1,76,333 healthy controls. Based on the random effects model, periodontitis was associated with an increased risk of ED (OR = 2.56, 95% CI: 1.70–3.85) as compared with the non-periodontitis individuals. The findings were statistically significant with a p < .0001. The statistical heterogeneity was high across all studies ( I2 = 98%, p < .00001). Estimates of total effects were generally consistent with the sensitivity and subgroup analyses. Within the limits of the available evidence, our review and meta-analysis showed that a significant association exists between the PD and ED. The results should be interpreted with caution due to high degree of inconsistency across all the studies.

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Validity of the association between periodontitis and female infertility conditions: a concise review

Cited by 20 publications

References 167 publications

Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis

Vitamin D and Periodontitis: A Systematic Review and Meta-Analysis

Comparisons of Periodontal Status between Females Referenced for Fertility Treatment and Fertile Counterparts: A Pilot Case–Control Study

The Association Between Periodontitis and Erectile Dysfunction: A Systematic Review and Meta-Analysis

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