Validity of the Chinese version Mood Disorder Questionnaire (MDQ) and the optimal cutoff screening bipolar disorders

Huang, Yang; Yuan, Chen; Liu, Tiebang; Li, Lingjiang; Peng, Hongjun; Han, Rong; Liao, Chun-ping; Shen, Qijie; Fang, Yiru

doi:10.1016/j.psychres.2011.02.007

Cited by 39 publications

(37 citation statements)

References 27 publications

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“…Compared to the optimal cut-off of 7 reported by studies from western countries [5,7] and Hong Kong [9], this study showed a smaller optimal cut-off, which was similar to findings from Chinese mainland [23]. This might partly due to the cultural differences, since Hong Kong is a very westernized city in China, which makes its culture and language greatly different from Chinese mainland.…”

Section: Discussionsupporting

confidence: 78%

Validation of the Chinese version of the "Mood Disorder Questionnaire" for screening bipolar disorder among patients with a current depressive episode

Zhang

Han

et al. 2012

BMC Psychiatry

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BackgroundThe Mood Disorder Questionnaire (MDQ) is a well-recognized screening tool for bipolar disorder, but its Chinese version needs further validation. This study aims to measure the accuracy of the Chinese version of the MDQ as a screening instrument for bipolar disorder (BPD) in a group of patients with a current major depressive episode.Methods142 consecutive patients with an initial DSM-IV-TR diagnosis of a major depressive episode were screened for BPD using the Chinese translation of the MDQ and followed up for one year. The final diagnosis, determined by a special committee consisting of three trained senior psychiatrists, was used as a 'gold standard' and ROC was plotted to evaluate the performance of the MDQ. The optimal cut-off was chosen by maximizing the Younden's index.ResultsOf the 142 patients, 122 (85.9%) finished the one year follow-up. On the basis of a semi-structured clinical interview 48.4% (59/122) received a diagnosis of unipolar depression (UPD), 36.9% (45/122) BPDII and 14.8% (18/122) BPDI. At the end of the one year follow-up,9 moved from UPD to BPD, 2 from BPDII to UPD, 1 from BPDII to BPDI, the overall rate of initial misdiagnosis was 16.4%. MDQ showed a good accuracy for BPD: the optimal cut-off was 4, with a sensitivity of 0.72 and a specificity of 0.73. When BPDII and BPDI were calculated independently, the optimal cut-off for BPDII was 4, with a sensitivity of 0.70 and a specificity of 0.73; while the optimal cut-off for BPDI was 5, with a sensitivity of 0.67 and a specificity of 0.86.ConclusionsOur results show that the Chinese version of MDQ is a valid tool for screening BPD in a group of patients with current depressive episode on the Chinese mainland.

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Section: Discussionsupporting

confidence: 78%

Validation of the Chinese version of the "Mood Disorder Questionnaire" for screening bipolar disorder among patients with a current depressive episode

Zhang

Han

et al. 2012

BMC Psychiatry

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“…Results from other studies of the MDQ in clinical settings have included PPV ranging from to 18.4%–96% (depending on cutoff) 12,23,24. In our study, the optimal question #1 item threshold value of at least five positive items was comparable with that reported in studies from China13,25 but was more liberal than the question #1 item threshold value of at least seven positive items reported in studies from the United States,10 France,26 Turkey,24 and Hong Kong 23. It has been proposed that the difference in optimal cutoff value from these studies might partly be due to cultural differences 25…”

Section: Discussionsupporting

confidence: 80%

Development and validation of a screening instrument for bipolar spectrum disorder: The Mood Disorder Questionnaire Thai version

Waleeprakhon¹,

Ittasakul²,

Lotrakul³

et al. 2014

NDT

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BackgroundThe Mood Disorder Questionnaire (MDQ) has been translated to many languages and has been used in many countries as a screening instrument for bipolar disorder. The main objective of this study was to evaluate validity of the Thai version of the MDQ as a screening instrument for bipolar disorder in a psychiatric outpatient sample, and to determine its optimum question #1 item threshold value for bipolar disorder.MethodsThe English language Mood Disorder Questionnaire (MDQ) was translated into Thai. The process involved back-translation, cross-cultural adaptation, field testing of the prefinal version, as well as final adjustments. Two hundred and fifty major depressive disorder outpatients were further assessed by the Thai version of the MDQ and the Thai version of the Mini International Neuropsychiatric Interview (MINI). During the assessment, reliability and validity analyses, and receiver operating characteristic curve (ROC) analysis were performed.ResultsThe Thai version of the MDQ screening had adequate internal consistency (Cronbach’s alpha =0.791, omega total =0.68, and omega hierarchical =0.69). The optimal question #1 item threshold value was at least five positive items, which yielded adequate sensitivity (76.5%), specificity (72.7%), positive predictive value (74.3%), and negative predictive value (75.0%). The ROC area under the curve (AUC) for this study was 0.82 (95% confidence interval: 0.70 to 0.90).ConclusionThe Thai version of the MDQ had some useful psychometric properties for screening for bipolar disorder in a mood disorder clinic setting, with a recommended question #1 item threshold value of at least five positive items.

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“…It consists of three parts, including 13 forced-choice (yes or no) questions to evaluate the presence of symptoms and behaviors related to mania or hypomania, one question to determine whether two or more symptoms have been experienced at the same time, and one question to determine the extent to which symptoms have caused functional impairment on a scale ranging from “no problems” to “serious problems”. Its internal reliability was .79 in a Chinese population sample [37]. …”

Section: Methodsmentioning

confidence: 99%

Inhibitory brainstem reflexes under external emotional-stimuli in bipolar I and II disorders

Zhu¹,

Wang²,

Shen³

et al. 2017

BMC Psychiatry

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BackgroundBipolar disorder types I (BD I) and II (BD II) might present different dysfunctions of the cortex and brainstem, as reflected by the second exteroceptive suppression period of temporalis muscle activity (ES2) under different stimuli of external emotions.MethodsThis study included 30 BD I and 20 BD II patients, and 40 healthy volunteers. All participants were invited to answer the Mood Disorder Questionnaire, the Hypomania Checklist-32, and the Plutchik-van Praag Depression inventory, as well as to undergo the ES2 test under external emotional-stimuli (emotional pictures plus sounds) of Disgust, Erotica, Fear, Happiness, and Sadness.ResultsThe scale scores were elevated in both patient groups, but were not correlated with ES2 parameters. Compared to healthy controls, BD I showed prolonged ES2 latency under Erotica, and their perceived happiness and sadness intensities were negatively correlated with the respective ES2 durations, while BD II showed prolonged ES2 latencies under Disgust and Happiness, and shortened ES2 durations under Disgust, Happiness and Sadness. Moreover, ES2 duration under Sadness was significantly shorter in BD II than that in BD I.ConclusionsThe cortico-brainstem inhibitory dysfunctions in BD I and BD II was different, and this difference was independent of the patient’s ongoing emotions. Our study thus provides some hints to distinguish the two types of bipolar disorders.

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Validity of the Chinese version Mood Disorder Questionnaire (MDQ) and the optimal cutoff screening bipolar disorders

Cited by 39 publications

References 27 publications

Validation of the Chinese version of the "Mood Disorder Questionnaire" for screening bipolar disorder among patients with a current depressive episode

Validation of the Chinese version of the "Mood Disorder Questionnaire" for screening bipolar disorder among patients with a current depressive episode

Development and validation of a screening instrument for bipolar spectrum disorder: The Mood Disorder Questionnaire Thai version

Inhibitory brainstem reflexes under external emotional-stimuli in bipolar I and II disorders

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