Valproate modulates the expression of methylphenidate (ritalin) sensitization

Peng, Yang; Beasley, Anitra; Swann, Alan C.; Dafny, Nachum

doi:10.1016/s0006-8993(00)02500-2

Cited by 29 publications

(27 citation statements)

References 20 publications

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“…They also showed that lithium has no effect on sensitization to methylphenidate once it has developed. In another study this group demonstrated that, like lithium, valproate has no effect on sensitization to methylphenidate that has already been induced (Yang et al, 2000). Administration of valproate both during methylphenidate exposure and during the washout period preceding re-challenge does, however, suppressed the subsequent expression of sensitization.…”

Section: The Effect Of Lithium On Behavioral Sensitizationmentioning

confidence: 98%

The behavioral actions of lithium in rodent models: Leads to develop novel therapeutics

O’Donnell

Gould

2007

Neuroscience & Biobehavioral Reviews

121

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For nearly as long as lithium has been in clinical use for the treatment of bipolar disorder, depression, and other conditions, investigators have attempted to characterize its effects on behaviors in rodents. Lithium consistently decreases exploratory activity, rearing, aggression, and amphetamine-induced hyperlocomotion; and it increases the sensitivity to pilocarpine-induced seizures, decreases immobility time in the forced swim test, and attenuates reserpine-induced hypolocomotion. Lithium also predictably induces conditioned taste aversion and alterations in circadian rhythms. The modulation of stereotypy, sensitization, and reward behavior are less consistent actions of the drug. These behavioral models may be relevant to human symptoms and to clinical endophenotypes. It is likely that the actions of lithium in a subset of these animal models are related to the therapeutic efficacy, as well the side effects, of the drug. We conclude with a brief discussion of various molecular mechanisms by which these lithium-sensitive behaviors may be mediated, and comment on the ways in which rat and mouse models can be used more effectively in the future to address persistent questions about the therapeutically relevant molecular actions of lithium.

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Section: The Effect Of Lithium On Behavioral Sensitizationmentioning

confidence: 98%

The behavioral actions of lithium in rodent models: Leads to develop novel therapeutics

O’Donnell

Gould

2007

Neuroscience & Biobehavioral Reviews

121

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“…Groups II, III, and IV were treated with 0.6, 2.5, or 10.0 mg/kg MPD, i.p., respectively. This experimental protocol was adapted from previous dose-response experiments of MPD and amphetamine [19,21,22,[65][66][67][68].…”

Section: Animalsmentioning

confidence: 99%

Acute and chronic methylphenidate dose–response assessment on three adolescent male rat strains

Peng¹,

Swann²,

Dafny³

2006

Brain Research Bulletin

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Methylphenidate (MPD), commonly known as Ritalin, is the most frequently prescribed drug to treat children and adults with attention deficit hyperactivity disorder (ADHD). Adolescence is a period of development involving numerous neuroplasticities throughout the central nervous system (CNS). Exposure to a psychostimulant such as MPD during this crucial period of neurodevelopment may cause transient or permanent changes in the CNS. Genetic variability may also influence these differences. Thus, the objective of the present study was to determine whether acute and chronic administration of MPD (0.6, 2.5, or 10.0 mg/kg, i.p.) elicit effects among adolescent WKY, SHR, and SD rats and to compare whether there were strain differences. An automated, computerized, open-field activity monitoring system was used to study the dose response characteristics of acute and repeated MPD administration throughout the 11-day experimental protocol. Results showed that all three adolescent rat groups exhibited dose-response characteristics following acute and chronic MPD administration, as well as strain differences. These strain differences depended on the MPD dose and locomotor index. Chronic treatment of MPD in these animals did not elicit behavioral sensitization, a phenomenon described in adult rats that is characterized by the progressive augmentation of the locomotor response to repeated administration of the drug. These results suggest that the animal's age at time of drug treatment and strain/genetic variability play a crucial role in the acute and chronic effect of MPD and in the development of behavioral sensitization.

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“…After 24h of acclimation to these cages, rats were divided randomly into 4 treatment groups: saline, 0.6 mg/kg, 2.5 mg/kg and 10.0 mg/kg MPD (each group N = 8). Their activity was monitored continuously (sample time: 10 min) throughout the 24h cycle for 2 days (Gaytan et al, 1996(Gaytan et al, , 2000Yang et al, 2000) following daily intraperitoneal (i.p.) saline/MPD administration.…”

Section: Behavioral Experimentsmentioning

confidence: 99%

“…Since treatment of ADHD can continue for years, most studies on MPD have centered on its abused potential and the effects of its long-term administration on behavior (Kollins et al, 2001). Repetitive use of stimulants such as amphetamine, cocaine and MPD elicits sensitization to their own stimulating locomotor and stereotypic effects in animals (Post and Rose, 1976;Kalivas et al, 1988;Gaytan et al, 1996;Yang et al, 2000).…”

Section: Introductionmentioning

confidence: 99%