Valproic acid and alopecia: A two-edged sword

Agrawal, Adesh Kumar; Das, Soumitra

doi:10.1016/j.ajp.2017.04.008

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Although systemic treatment with valproate causes hair loss, topical application of valproate is found to promote hair growth (Agrawal & Das, 2017;Jo et al, 2014;Kakunje et al, 2018). Valproate promotes transition of hair follicles from telogen to anagen; this transition is by upregulation of β-catenin expression by inhibition of glycogen synthase kinase 3β (Lee et al, 2015).…”

Section: Topical Valproate Therapymentioning

confidence: 99%

“…Paradoxically, oral valproic acid treatment in a 60-year-old with androgenic alopecia showed reduction in hair loss in 3 months, and improvement in hair density and thickness after 2 years of treatment with significant hair growth on the frontal area (Choi et al, 2014). It is possible that the effect of valproate therapy could be related to individual predisposition, hence, it is considered as a double-edged sword (Agrawal & Das, 2017).…”

Section: Topical Valproate Therapymentioning

confidence: 99%

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Valproate‐associated hair abnormalities: Pathophysiology and management strategies

Praharaj

Munoli

Udupa

et al. 2021

Human Psychopharmacology

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Objective: To review the literature on valproate-associated hair abnormalities and the available treatment options. Methods:We searched PubMed and Google Scholar with keywords including "valproate", "valproic acid", "hair", "alopecia", and "effluvium," supplemented with hand search from cross-references. We included all types of studies including case reports in this review. Results: The pathophysiology of hair loss includes telogen effluvium, biotin, mineral deficiency, and possibly hyperandrogenism. Diagnosis is based on history of hair loss or abnormalities following valproate treatment, and is confirmed by use of simple clinical tests such as pull test and modified wash test. Treatment involves reassurance and advice on hair care, and if possible drug discontinuation or dose reduction. Medications such as biotin and other vitamins with minerals supplementation is effective for most individuals with hair loss. Other treatment options are agomelatine, topical valproate or minoxidil, though these lack evidence. Conclusion: Hair abnormalities with valproate are common, benign adverse effects, and management includes general measures and specific treatment options.

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Section: Topical Valproate Therapymentioning

confidence: 99%

Section: Topical Valproate Therapymentioning

confidence: 99%

Valproate‐associated hair abnormalities: Pathophysiology and management strategies

Praharaj

Munoli

Udupa

et al. 2021

Human Psychopharmacology

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show abstract

“…Valproate is used regularly in the treatment of various seizure disorders, bipolar disorder, migraine prophylaxis, and off label in many other conditions. [ 1 2 ] It is a histone deacetylase inhibitor, exerting its action through modification of chromatin structure and gene expression. It is also involved in the modulation of ERK and Wnt-beta-Catenin signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

Valproate: It's effects on hair

et al. 2018

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Valproate is a drug used in the treatment of various seizure disorders, bipolar disorder, migraine prophylaxis, and off label in many indications by various specialists. The common adverse drug reactions reported on valproate administration are tremor, weight gain, gastrointestinal disturbances, liver dysfunction, metabolic acidosis, thrombocytopenia, and hair loss. An internet search with keywords “valproate” and “hair” was done on Google Search and PubMed for articles related to the topic. Recognition of cosmetically significant side effects on hair is necessary and neglect of which might result in poor compliance. Valproate-induced hair loss is diffused, nonscarring, and dose related. Other hair-related adverse events are curling of hair, graying, dirty appearance, and changes in texture. In contrast to oral ingestions causing hair loss, experiments with topical valproic acid have shown some initial evidence on hair regeneration. This makes valproate's effects on hair interesting and understanding it's effects on hair is very much essential in clinical practice.

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Formulation and Evaluation of Valproic Acid Microemulsions for Enhanced Transfollicular Delivery in Guinea Pig Skin

Salimi,

Jafarian,

Salimi

et al. 2024

J of Cosmetic Dermatology

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BackgroundValproic acid (VPA) is used to treat various neurological and psychiatric conditions. While oral VPA can cause hair loss, topical application has shown potential for hair regeneration. This study aimed to develop and evaluate microemulsion (ME) formulations of VPA for enhanced transfollicular delivery.MethodsVPA‐loaded MEs were prepared using oleic acid, Transcutol P, Tween 80, Labrasol, and Capryol 90. The MEs were characterized for physicochemical properties, stability, in vitro release, and ex vivo permeation through the hairy abdominal and nonhairy ear skin of guinea pigs.ResultsEight stable ME formulations were developed with droplet sizes ranging from 10 to 24 nm, pH 4.6 to 5.2, and viscosity 77 to 85 cps. In vitro release studies showed controlled release profiles over 24 h. Permeation studies revealed enhanced drug delivery through both follicular and nonfollicular pathways compared with aqueous VPA solution. Formulations with higher surfactant/cosurfactant ratios showed increased permeation through the follicular pathway.ConclusionThe ME formulations significantly enhanced VPA penetration into both epidermal and follicular pathways compared with aqueous solution. The composition of the MEs, particularly the oil content, water content, and surfactant/cosurfactant ratio, played a crucial role in determining the physicochemical properties and skin permeation parameters of VPA.

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Valproic acid and alopecia: A two-edged sword

Cited by 3 publications

References 9 publications

Valproate‐associated hair abnormalities: Pathophysiology and management strategies

Valproate‐associated hair abnormalities: Pathophysiology and management strategies

Valproate: It's effects on hair

Formulation and Evaluation of Valproic Acid Microemulsions for Enhanced Transfollicular Delivery in Guinea Pig Skin

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