Value-added fermentation of Ecklonia cava processing by-product and its antioxidant effect

Wijesinghe, W.A.J.P.; Lee, Wonwoo; Kim, Young‐Mog; Kim, Youngtae; Kim, Se-Kwon; Byong-Tae, Jeon; Min-Soo, Heu; Won-Kyo, Jung; Ahn, Ginnae; Lee, Ki-Wan; Jeon, You‐Jin

doi:10.1007/s10811-011-9668-1

Cited by 21 publications

(6 citation statements)

References 46 publications

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“…In another study, an antioxidant phloroglucinol was isolated and the isolated compound found to possess similar antioxidant activity with L-ascorbic acid (Lee et al 1996). One of our previous works demonstrated the antioxidant effect of fermented E. cava processing by-product (Wijesinghe et al 2011). Further we reported that, the antioxidant activity of E. cava processing by-product mainly due to the phlorotannins in the extract.…”

Section: Biological Activities Of Brown Seaweeds With Special Focusesmentioning

confidence: 93%

Biological activities and potential cosmeceutical applications of bioactive components from brown seaweeds: a review

2011

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Seaweeds are the primary producers of all aquatic ecosystems. Chemical constituents isolated from diverse classes of seaweeds exert a wide range of nutritional, functional and biological activities. Unique metabolites of seaweeds possess specific biological properties that make them potential ingredients of many industrial applications such as functional foods, pharmaceuticals and cosmeceuticals. Cosmeceuticals of natural origin are becoming more popular than synthetic cosmetics. Hence, the investigation of new seaweeds derived functional components, a different source of natural products, has proven to be a promising area of cosmeceutical studies. Brown seaweeds also produce a range of active components including unique secondary metabolites such as phlorotannins and many of which have specific biological activities that give possibilities for their economic utilization. Brown seaweeds derived active compounds have been shown various functional properties including, antioxidant, antiwrinkling, whitening, antiinflammatory and antiallergy.It is well-known that these kind of biological effects are closely associated with cosmeceutical preparations. This communication reviews the current knowledge on brown seaweeds derived metabolites with various biological activities and the potential use as cosmeceutical ingredients. It is hoped that the reviewed literature on multifunctional properties of brown seaweeds will improve access to the seaweed based natural products specially the ability to incorporate these functional properties in cosmeceutical applications.

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Section: Biological Activities Of Brown Seaweeds With Special Focusesmentioning

confidence: 93%

Biological activities and potential cosmeceutical applications of bioactive components from brown seaweeds: a review

2011

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“…Wijesinghe et al [85] confirmed the presence of PHT triphloroethol-A, eckol, dieckol, and eckstolonol in investigated Ecklonia calva samples, while Machu et al [62] confirmed the presence of gallic acid ( E. bicyclis, H. fusiformis ), 4-hydroxybenzoic acid ( U. pinnatifida ), epicatechin ( E. bicyclis , Sargassum fusiforme, Saccharina japonica ), catechin gallate ( E. bicyclis, S. japonica ) and epigallocatechin ( S. japonica ).…”

Section: Brown Algae Phenolicsmentioning

confidence: 99%

Phenolic Content of Brown Algae (Pheophyceae) Species: Extraction, Identification, and Quantification

et al. 2019

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Over the last few decades, isolations and chemical characterizations of secondary metabolites with proved biological activities have been of interest for numerous research groups across the world. Phenolics, as one of the largest and most widely distributed group of phytochemicals, have gained special attention due to their pharmacological activity and array of health-promoting benefits. Reports on phenolic potentials of marine algae, especially brown algae (Pheophyceae) that are characterized by the presence of phlorotannins, are still scarce. The aim of this review paper is to provide an overview of current knowledge about phenolic potential of different brown algae species (74 species from 7 different orders). Studies on brown algae phenolics usually involve few species, thus the focus of this review is to provide information about the phenolic potential of reported algae species and to get an insight into some issues related to the applied extraction procedures and determination/quantification methods to facilitate the comparison of results from different studies. The information provided through this review should be useful for the design and interpretation of studies investigating the brown algae as a source of valuable phytochemicals.

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“…The cells were maintained at 37°C in humidified atmosphere of 5% CO 2 E. cava processing by-product (EPB) has both antioxidant and anti-inflammation effects and rich in polyphenols (Wijesinghe et al 2012(Wijesinghe et al , 2013. However, the anti-inflammatory effects of EPB have not yet been assessed.…”

Section: Cell Culturementioning

confidence: 99%

Polyphenol-rich fraction from Ecklonia cava (a brown alga) processing by-product reduces LPS-induced inflammation in vitro and in vivo in a zebrafish model

Kim¹,

Kim²,

Kang³

et al. 2014

ALGAE

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Ecklonia cava is a common edible brown algae that is plentiful in Jeju Island of Republic of Korea. Polyphenols from E. cava have strong anti-inflammatory activity. However, a large number of the by-products from E. cava processing are discarded. In the present study, to utilize these by-products, we assessed the anti-inflammatory activity of the polyphenol-rich fraction (PRF) from E. cava processing by-product (EPB) in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells. Four compounds, namely eckol, eckstolonol, dieckol, and phlorofucofuroeckol-A, were isolated and identified from PRF. We found that PRF suppressed the production of nitric oxide (NO), inducible nitric oxide synthase, and cyclooxygenase-2 in the LPS-induced cells. Furthermore, the protective effect of PRF was investigated in vivo in LPS-stimulated inflammation zebrafish model. PRF had a protective effect against LPS-stimulated toxicity in zebrafish embryos. In addition, PRF inhibited LPS-stimulated reactive oxygen species and NO generation. According to the results, PRF isolated from EPB could be used as a beneficial anti-inflammatory agent, instead of discard.Key Words: anti-inflammation; by-product; Ecklonia cava; polyphenol; seaweeds INTRODUCTIONSeaweeds are rich in vitamins, minerals, proteins, polyphenols, and polysaccharides. Therefore, several species of seaweeds are used in cosmetics, food, and pharmaceuticals. Many studies have shown that seaweeds have diverse bioactivities such as antioxidant, anticoagulant, anti-inflammation, antibacterial, and anticancer activities (Heo et al. 2003, Shin et al. 2006, Kim et al. 2007, Erbert et al. 2012, Ko et al. 2012. In particular, Ecklonia cava is a common edible brown algae that is plentiful in Jeju Island of Republic of Korea. E. cava has been identified to contain various natural substances such as carotenoids, fucoidans, and phlorotannins, which have beneficial biological activities including antioxidant, anti-inflammation, anticoagulant, antiviral, and antidiabetic effects (Kang et al. 2010, 2012b, 2013a. Dried forms of E. cava are consumed, but steam heated E. cava products sometimes are manufactured. When steaming the alga, a large amount of by-product is produced and discarded without utilization. Some studies have suggested that fermenting Received April 25, 2014, Accepted June 3, 2014 *Corresponding Author E-mail: youjinj@jejunu.ac.kr Tel: This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Preparation of PRF from EPBEPB was kindly provided by Taerim Co., Ltd. (Jeju, Korea) and then was freeze-dried. The dried EPB powder (5 g) was suspended in 500 mL of 80% ethanol and mechanically stirred for 24 h at room temperature. The solution was filtered and the filtrate was concentrated under reduced pressure to give the oily extract. Aft...

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Value-added fermentation of Ecklonia cava processing by-product and its antioxidant effect

Cited by 21 publications

References 46 publications

Biological activities and potential cosmeceutical applications of bioactive components from brown seaweeds: a review

Biological activities and potential cosmeceutical applications of bioactive components from brown seaweeds: a review

Phenolic Content of Brown Algae (Pheophyceae) Species: Extraction, Identification, and Quantification

Polyphenol-rich fraction from Ecklonia cava (a brown alga) processing by-product reduces LPS-induced inflammation in vitro and in vivo in a zebrafish model

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