Value and best way for detection of Sentinel lymph node in early stage endometrial cancer: Selective lymphadenectomy algorithm

El-Agwany, Ahmed Samy; Meleis, Mahmoud Hanafy

doi:10.1016/j.ejogrb.2018.03.042

Cited by 8 publications

(4 citation statements)

References 23 publications

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“…El-Agwany and Meleis concluded that the hysteroscopic-guided blue dye injection was the best technique for SLN detection, and the SLN can be used in patients with low risk for lymph node metastasis. [38] In addition, they found the blue methylene dye good for SLN detection in low-resource countries. [38]…”

Section: Methods Of Sentinel Lymph Node Detection In Endometrial Cancersmentioning

confidence: 99%

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Sentinel lymph nodes in endometrial cancer update 2018

Abdelazim

Abu-Faza²,

Zhurabekova

et al. 2019

Gynecol Minim Invasive Ther

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There are no established data about lymphadenectomy during treatment of endometrial cancers (ECs) and to what extent lymphadenectomy should be performed. In addition, retroperitoneal lymphadenectomy increases the intraoperative and postoperative complications. Sentinel lymph node (SLN) mapping has the lowest costs and highest quality-adjusted survival. SLN is the most cost-effective strategy in the management of low-risk ECs. Women staged with SLN mapping were more likely to receive adjuvant treatment compared with women staged with systemic lymphadenectomy. This review article designed to evaluate the diagnostic accuracy and the methods of SLN detection in ECs.

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Section: Methods Of Sentinel Lymph Node Detection In Endometrial Cancersmentioning

confidence: 99%

“…[38] In addition, they found the blue methylene dye good for SLN detection in low-resource countries. [38]…”

Section: Methods Of Sentinel Lymph Node Detection In Endometrial Cancersmentioning

confidence: 99%

Sentinel lymph nodes in endometrial cancer update 2018

Abdelazim

Abu-Faza²,

Zhurabekova

et al. 2019

Gynecol Minim Invasive Ther

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“…Similar to that in our study (Table 2), the incidence of metastases to the pelvic lymph nodes in patients with early-stage EC who underwent lymphadenectomy varies between 10% and 20% in previous studies. 23,33 In the earlier works with UA ligation performed prior to TLH, UA is ligated in the neighborhood of ureter after being separated from IIA 13,16 and the mechanical and thermal damage risk to ureter is very high in this anatomic area during the ligation procedure. In our study, prophylactic ligation of UA at its origin was carried out directly under observation at a point just proximal to its origin.…”

Section: Discussionmentioning

confidence: 99%

Prophylactic ligation of uterine arteries at its origin in laparoscopic surgical staging for endometrial cancer

Yavuzcan

Bakay

2021

J of Obstet and Gynaecol

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Aim:The aim of this study was to compare the surgical outcomes between patients who were staged laparoscopically for early-stage endometrioid-type endometrial cancer (EC) between those who underwent prophylactic ligation of uterine arteries (UAs) prior to pelvic lymphadenectomy and the patients who were operated with standard procedure. Methods: This retrospective study was conducted in women diagnosed with early-stage and low/ intermediate-risk endometrioid-type EC. The control group included patients who underwent standard laparoscopic pelvic lymphadenectomy and the study group concerned patients who underwent prophylactic ligation of UA prior to pelvic lymphadenectomy. The prophylactic ligation of UA procedure was performed at a point just proximal to its origin. Results: The mean lymph node count dissected in the study group was higher in terms of statistical significance (17.5 AE 2.2 vs. 19.8 AE 3.6, p = 0.003 and p < 0.05). The rate of the patients who had a positive pelvic lymph node detected did not differ between groups (7.4% vs. 16.7%, p = 0.258 and p < 0.05). The operation time (OT) of the patients in the study group did not differ between groups (p = 0.546 and p < 0.05). Hemoglobin drop (À0.5 AE 0.7) and hematocrite drop (À0.8 AE 0.9) values in the study group were found to be lower in the study group (p = 0.000, p = 0.000, and p < 0.05). Conclusions: Performing prophylactic ligation of UA at its origin prevents unwanted bleeding and facilitates the laparoscopic pelvic lymphadenectomy procedure.

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“…Currently, patients diagnosed with EC who can be treated conservatively need to meet the criteria of being high differentiation and without myometrial invasion [ 8 , 14 ]. The site of metastasis and regional lymph node metastasis (LNM) status of EC patients are important indicators for surgical pathologic staging by the International Federation of Gynecology and Obstetrics (FIGO), as well as important references for evaluating prognosis and guiding treatment [ 15 ]. Moreover, LNM and other extra-uterine metastases are highly correlated with the extent of malignant differentiation and the depth of myometrial invasion [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Risk assessment of extra-uterine involvement and prognosis in young type I endometrial carcinoma with high or moderate differentiation and less than 1/2 myometrial invasion

Sun,

Han,

Wang

et al. 2024

Aging

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Purpose: The aim of this study was to investigate whether young patients with endometrial carcinoma can preserve adnexa and lymph nodes to improve their quality of life without compromising their prognosis. Methods: A total of 319 patients with type I endometrial carcinoma (high or moderate differentiation and less than 1/2 myometrial invasion) hospitalized in the First Affiliated Hospital of Zhengzhou University from May 2012 to July 2021 were included. The patients were divided into four groups: high differentiation without myometrial invasion group (G1MI-), high differentiation with superficial myometrial invasion group (G1MI+), moderate differentiation without myometrial invasion group (G2MI-), and moderate differentiation with superficial myometrial invasion group (G2MI+). Logistic regression analysis was conducted to identify risk factors for extra-uterine involvement. Kaplan-Meier method was used to draw the survival curve to compare the prognosis in subgroups and rates of extra-uterine involvement were also compared using Chi-square test or Fisher’s exact test. Results: Multivariable logistic regression revealed that differentiation (HR = 14.590, 95%CI = 1.778-119.754, p = 0.013) and myometrial invasion (HR = 10.732, 95%CI = 0.912-92.780, p = 0.037) were the independent risk factors for extra-uterine involvement. The overall difference was statistically significant ( p < 0.001). In the subgroups analysis, both adnexal metastasis and lymph node metastasis were statistically significant in the G2MI+ group compared with G1MI- ( p = 0.007, p = 0.008). There were no significant differences in the overall survival (OS) rate and progression free survival (PFS) rate among the four subgroups ( p > 0.05). Conclusions: Surgery with adnexal preservation and without systematic lymphadenectomy could be employed for the patients who are high differentiation with less than 1/2 myometrial invasion or moderate differentiation without myometrial invasion, but not recommended to the patients with moderate differentiation and superficial myometrial invasion.

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Value and best way for detection of Sentinel lymph node in early stage endometrial cancer: Selective lymphadenectomy algorithm

Cited by 8 publications

References 23 publications

Sentinel lymph nodes in endometrial cancer update 2018

Sentinel lymph nodes in endometrial cancer update 2018

Prophylactic ligation of uterine arteries at its origin in laparoscopic surgical staging for endometrial cancer

Risk assessment of extra-uterine involvement and prognosis in young type I endometrial carcinoma with high or moderate differentiation and less than 1/2 myometrial invasion

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