Value of [68Ga]Ga-FAPI-04 Imaging in the Diagnosis of Renal Fibrosis

Zhou, Yue; Yang, Xin; Liu, Huipan; Luo, Wei; Liu, Hanxiang; Lv, Taiyong; Wang, Junzheng; Qin, Jianhua; Ou, Santao; Chen, Yue

doi:10.21203/rs.3.rs-244050/v1

Cited by 11 publications

(14 citation statements)

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“…We purchased the precursor FAPI-04 from MCE (MedChemExpress, USA), with a purity of 98% and a quality of 872.91. The 68 Ga-FAPI labeling was carried out according to the method described previously ( 10 ). The radiochemical purity of 68 Ga-FAPI exceeded 95%.…”

Section: Methodsmentioning

confidence: 99%

Clinical Significance of Diffusely Increased Uptake of 68Ga-FAPI in Thyroid Gland

et al. 2021

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Purpose: To determine the clinical significance of diffuse uptake of 68Ga-FAPI in the thyroid.Methods: From January 2020 to September 2021, all subjects with diffuse thyroid uptake in 68Ga-FAPI PET/CT were investigated in our hospital, and compared with the age and sex matched control group. The 68Ga-FAPI uptake in the thyroid gland was analyzed semi-quantitatively using the maximum standardized uptake value (SUVmax), and regression analysis was used to analyze the correlation between available serum thyroid stimulating hormone (TSH) and thyroid peroxidase antibody (TPOAb).Results: Among 815 subjects, 39 subjects were found diffuse FAPI uptake in thyroid gland; 11 subjects refused further examination; a total of 28 subjects were included in the analysis, and 27 subjects were diagnosed with chronic thyroiditis (including 20 subjects with Hashimoto's thyroiditis), 3 subjects with Grave's disease, 3 subjects with only serum TSH elevated, and 1 subject with malignant of thyroid and thyroiditis. The SUVmax of 27 subjects with thyroiditis was 5.75 ± 5.45. No significant correlation was found between the SUVmax and the level of serum TSH (P = 0.389) or TPOAb (P = 0.426).Conclusion: The incidentally discovered diffusely increased 68Ga-FAPI uptake in the thyroid gland is mostly related to chronic lymphocytic (Hashimoto's) thyroiditis. 68Ga-FAPI uptake level correlated neither with the degree of hypothyroidism nor with the titer of TPOAb. In addition, immune-related thyroiditis with immune checkpoint inhibitors may be accidentally found on 68Ga-FAPI, which may be helpful in facilitate timely intervention.

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Section: Methodsmentioning

confidence: 99%

Clinical Significance of Diffusely Increased Uptake of 68Ga-FAPI in Thyroid Gland

et al. 2021

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“…3,4 Recently, it has gradually shown value in some inflammatory diseases, including nephritis, pancreatitis, cholecystitis, and pneumonia. [5][6][7][8] In this case, bone tuberculous granulomatous inflammation can cause increased FAPI activity. This is consistent with the previous report that extrapulmonary tuberculosis can cause increased FAPI activity.…”

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confidence: 94%

Bone Tuberculous Granulomatous Inflammation Mimicking Malignancy on 68Ga-FAPI PET/CT

et al. 2022

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A 50-year-old woman presented with back pain for 1 month. Chest CT showed osteolytic destruction of T6 vertebral body. A malignancy was suspected. The patient was subsequently enrolled in the clinical trial of 68 Ga-FAPI PET/CT. 68 Ga-FAPI PET/CT revealed multiple bone destruction with increased FAPI activity. It was also highly suggestive of malignancy or metastases. However, pathological examination after T6 vertebral surgery confirmed the diagnosis of tuberculous granulomatous inflammation.

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“…Fibroblast activation protein (FAP) is involved in inflammatory and fibrotic tissues. [3][4][5] Smooth muscle cells are differentiated from fibroblast-like cells. Therefore, angiomyolipoma may show intense FAPI activity.…”

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confidence: 99%