Value of C-11 methionine PET/CT in patients with intracranial germinoma

Park, Yong‐Jin; Lee, Ji Won; Cho, Hee Won; Choe, Yearn Seong; Lee, Kyung-Han; Choi, Joon Young; Sung, Ki Woong; Moon, Seung Hwan

doi:10.1371/journal.pone.0263690

Cited by 3 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It may be appreciated that even with the availability of tumor tissue, the interpretation of histology may be hampered by sampling bias, tissue heterogeneity and the prominent inflammatory infiltrates frequently present in CNS GCTs. Recently, there has been increasing interest in the application of 11C-MET PET-MRI as a diagnostic tool in patients with intracranial neoplasms [40,41], including initial experience in patients with CNS GCTs [42][43][44][45][46][47]. Such a methodology offers functional data that complement the anatomical data captured by MRI alone.…”

Section: Discussionmentioning

confidence: 99%

Incidence and Predictors for Oncologic Etiologies in Chinese Children with Pituitary Stalk Thickening

Li¹,

Poon

Cheung³

et al. 2023

Cancers

View full text Add to dashboard Cite

Background: With the increasing use of magnetic resonance imaging (MRI) in the evaluation of children with endocrine disorders, pituitary stalk thickening (PST) poses a clinical conundrum due to the potential for underlying neoplasms and challenges in obtaining a tissue biopsy. The existing literature suggests Langerhans cell histiocytosis (LCH) to be the commonest (16%) oncologic cause for PST, followed by germ cell tumors (GCTs, 13%) (CCLG 2021). As the cancer epidemiology varies according to ethnicity, we present herein the incidence and predictors for oncologic etiologies in Hong Kong Chinese children with PST. Methods: Based on a territory-wide electronic database, we reviewed patients aged < 19 years who presented to three referral centers with endocrinopathies between 2010 and 2022. Records for patients who underwent at least one MRI brain/pituitary were examined (n = 1670): those with PST (stalk thickness ≥ 3 mm) were included, while patients with pre-existing cancer, other CNS and extra-CNS disease foci that were diagnostic of the underlying condition were excluded. Results: Twenty-eight patients (M:F = 10:18) were identified. The median age at diagnosis of PST was 10.9 years (range: 3.8–16.5), with central diabetes insipidus (CDI) and growth hormone deficiency (GHD) being the most frequent presenting endocrine disorders. At a median follow-up of 4.8 years, oncologic diagnoses were made in 14 patients (50%), including 13 GCTs (46%; germinoma = 11, non-germinoma = 2) and one LCH (4%). Among patients with GCTs, 10 were diagnosed based on histology, two by abnormal tumor markers and one by a combination of histology and tumor markers. Three patients with germinoma were initially misdiagnosed as hypophysitis/LCH. The cumulative incidence of oncologic diagnoses was significantly higher in boys and patients with PST at presentation ≥6.5 mm, CDI or ≥2 pituitary hormone deficiencies at presentation and evolving hypopituitarism (all p < 0.05 by log-rank). Conclusions: A higher rate of GCTs was observed in Chinese children with endocrinopathy and isolated PST. The predictors identified in this study may guide healthcare providers in Asia in clinical decision making. Serial measurement of tumor markers is essential in management.

show abstract

Section: Discussionmentioning

confidence: 99%

Incidence and Predictors for Oncologic Etiologies in Chinese Children with Pituitary Stalk Thickening

Li¹,

Poon

Cheung³

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

“…Park et al also described the application of 11 C-Met in intracranial germinoma, observing that 11 C-Met PET parameters had a significant association with tumor location, sex, KRAS variant, and symptoms [100]. Morales-Lozano et al also compared 11 C-Met and 18 F-FDG in multiple myeloma, and they confirmed that 11 C-Met PET/CT was more sensitive than 18 F-FDG for evaluation of myeloma tumors [101].…”

Section: Methioninementioning

confidence: 96%

Application of Metabolic Reprogramming to Cancer Imaging and Diagnosis

Yang

Cai

et al. 2022

IJMS

View full text Add to dashboard Cite

Cellular metabolism governs the signaling that supports physiological mechanisms and homeostasis in an individual, including neuronal transmission, wound healing, and circadian clock manipulation. Various factors have been linked to abnormal metabolic reprogramming, including gene mutations, epigenetic modifications, altered protein epitopes, and their involvement in the development of disease, including cancer. The presence of multiple distinct hallmarks and the resulting cellular reprogramming process have gradually revealed that these metabolism-related molecules may be able to be used to track or prevent the progression of cancer. Consequently, translational medicines have been developed using metabolic substrates, precursors, and other products depending on their biochemical mechanism of action. It is important to note that these metabolic analogs can also be used for imaging and therapeutic purposes in addition to competing for metabolic functions. In particular, due to their isotopic labeling, these compounds may also be used to localize and visualize tumor cells after uptake. In this review, the current development status, applicability, and limitations of compounds targeting metabolic reprogramming are described, as well as the imaging platforms that are most suitable for each compound and the types of cancer to which they are most appropriate.

show abstract

“…Studies in xenograft mouse models show that treatment with recombinant methioninase, an enzyme that depletes plasma methionine levels, and/or a methionine-restricted diet can decrease tumor volume [10][11][12][13][14]. Clinically, the enhanced usage of methionine in cancer cells can be used to localize tumors with [ 11 C]-methionine positron emission tomography (MET--PET), particularly for cancers in the brain as well as organ cancers [15][16][17]. Additionally, methionine restriction has been used as a combination treatment with chemotherapy in cancer patients [9].…”

Section: Introductionmentioning

confidence: 99%

Asymmetric and symmetric protein arginine methylation in methionine-addicted human cancer cells

Holtz,

Lowe,

Aoki

et al. 2023

PLoS ONE

View full text Add to dashboard Cite

The methionine addiction of cancer cells is known as the Hoffman effect. While non-cancer cells in culture can utilize homocysteine in place of methionine for cellular growth, most cancer cells require exogenous methionine for proliferation. It has been suggested that a biochemical basis of this effect is the increased utilization of methionine for S-adenosylmethionine, the major methyl donor for a variety of cellular methyltransferases. Recent studies have pointed to the role of S-adenosylmethionine-dependent protein arginine methyltransferases (PRMTs) in cell proliferation and cancer. To further understand the biochemical basis of the methionine addiction of cancer cells, we compared protein arginine methylation in two previously described isogenic cell lines, a methionine-addicted 143B human osteosarcoma cell line and its less methionine-dependent revertant. Previous work showed that the revertant cells were significantly less malignant than the parental cells. In the present study, we utilized antibodies to detect the asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) products of PRMTs in polypeptides from cellular extracts and purified histone preparations of these cell lines fractionated by SDS-PAGE. Importantly, we observed little to no differences in the banding patterns of ADMA- and SDMA-containing species between the osteosarcoma parental and revertant cell lines. Furthermore, enzymatic activity assays using S-adenosyl-ʟ-[methyl-3H] methionine, recombinantly purified PRMT enzymes, cell lysates, and specific PRMT inhibitors revealed no major differences in radiolabeled polypeptides on SDS-PAGE gels. Taken together, these results suggest that changes in protein arginine methylation may not be major contributors to the Hoffman effect and that other consequences of methionine addiction may be more important in the metastasis and malignancy of osteosarcoma and potentially other cancers.

show abstract

Value of C-11 methionine PET/CT in patients with intracranial germinoma

Cited by 3 publications

References 24 publications

Incidence and Predictors for Oncologic Etiologies in Chinese Children with Pituitary Stalk Thickening

Incidence and Predictors for Oncologic Etiologies in Chinese Children with Pituitary Stalk Thickening

Application of Metabolic Reprogramming to Cancer Imaging and Diagnosis

Asymmetric and symmetric protein arginine methylation in methionine-addicted human cancer cells

Contact Info

Product

Resources

About