Value of multi-detector computed tomography during intra-arterial infusion of contrast medium for locating insulinomas

Song, Peng; Yan, Jie; Wang, Yan; Xiao, Li

doi:10.1177/0300060519889432

Cited by 4 publications

(4 citation statements)

References 19 publications

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“…Kang et al (29) analyzed the factors associated with missed and misinterpreted cases of pancreatic ductal adenocarcinoma, they found that a significant number of missed tumors were <2 cm (45/107, 42%), iso-attenuating on CT (32/72, 44%) or non-contour deforming (44/107, 41%), and most (29/49, 59%) misinterpreted examinations were reported as uncomplicated pancreatitis. Therefore, given that differentiation between pancreatic adenocarcinoma and focal chronic pancreatitis remains a challenge in CECT (30), the low specificity of CECT for depicting pancreatic carcinoma in this study seems reasonable; besides, the low amount of disease negative patients may also be a factor causing the low specificity. This also resulted in the low combined specificity in the total group.…”

Section: Discussionmentioning

confidence: 86%

The diagnostic performance of contrast-enhanced ultrasound versus contrast-enhanced computed tomography for pancreatic carcinoma: a systematic review and meta-analysis

Yan¹,

Lv²,

Xiao³

et al. 2022

Transl Cancer Res TCR

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Background: Pancreatic carcinoma is a highly fatal disease, and early diagnosis is of vital importance. This meta-analysis aimed to compare the diagnostic performances of contrast-enhanced ultrasonography (CEUS) against contrast-enhanced computed tomography (CECT) for pancreatic carcinoma, using pathological results or alternative imaging modality as the gold standard.Methods: A thorough search was conducted in PubMed, EMBASE, Web of Science and Cochrane Library databases. Two investigators selected the studies and extracted the data independently. A bivariate mixedeffects regression model was used to calculate the pooled data. Subgroup analysis and meta-regression were performed to explore the causes of heterogeneity.Results: A total of 1,227 records were identified, of which 7 articles with 588 patients were assessed for eligibility. The overall sensitivity, specificity of CEUS and CECT with their 95% confidential intervals (95%

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Section: Discussionmentioning

confidence: 86%

The diagnostic performance of contrast-enhanced ultrasound versus contrast-enhanced computed tomography for pancreatic carcinoma: a systematic review and meta-analysis

Yan¹,

Lv²,

Xiao³

et al. 2022

Transl Cancer Res TCR

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“…Tumor location was successfully determined in 12/12 patients by MDCT-IA (100%) compared to 9/11 by magnetic resonance imaging (81.8%), 4/7 by CT (57.1%) and 7/12 by ultrasound-enhanced contrast (CEUS) (58.3%). Overall, MDCT-IA correctly located 100% of the lesions [10].…”

Section: Discussionmentioning

confidence: 92%

“…Conventional computed tomography (CT) has sensitivity comparable to that of ultrasound, ranging from 22% to 43%. Multidetector computed tomography during intraarterial infusion of contrast medium (MDCT-IA) was evaluated in the study reported by Song P and collaborators [10] for the location of insulinomas in 12 patients, who were surgically treated. Tumor location was successfully determined in 12/12 patients by MDCT-IA (100%) compared to 9/11 by magnetic resonance imaging (81.8%), 4/7 by CT (57.1%) and 7/12 by ultrasound-enhanced contrast (CEUS) (58.3%).…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemia In Non-Diabetic Patient: Report of Two Cases of Insulinoma

Rosa¹,

Jiménez-Arcia²,

Pérez-Calvo³

et al. 2022

Arch Metabolic Synd

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Background: Insulinoma is a B-cell tumor of the islets of the pancreas with an incidence of 4 per 1 million people per year, which produces excess insulin and can cause symptoms related to hypoglycemia at the level of the central nervous system or symptoms related to excess release of catecholamines. The presence of hypoglycemia, elevated insulin, proinsulin, and c-peptide levels suggest endogenous hyperinsulinism, which together with imaging findings suggestive of neuroendocrine tumor, allow establishing the diagnostic impression of Insulinoma. Case Report: Patients with neuroglycopenic symptoms, biochemical profile of hypoglycemia, endogenous hyperinsulinemia and radiological finding compatible with insulinoma are reported, who were treated by surgical resection of the tumor, with complete resolution of the initial symptoms. Conclusion: The clinical presentation, diagnosis and treatment of insulinoma represents a clinical challenge, since it is a rare pathology and the delay in diagnosis can have catastrophic consequences for the patient such as permanent brain damage and death.

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“…Overall, MDCT-IA correctly located 100% of the lesions. [8][9][10] Endoscopic ultrasound is considered by several authors as a reference test for preoperative insulinoma localization, with a sensitivity of about 80% to 93%. It can even detect small tumors in the order of 5 mm.…”

Section: Discussionmentioning

confidence: 99%

Hypoglycemia in Non-Diabetic Patient: Report of Two Cases of Insulinoma

Calvo¹

2022

SOJMCCR

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Background: Insulinoma is a B-cell tumor of the islets of the pancreas with an incidence of 4 per 1 million people per year, which produces excess insulin and can cause symptoms related to hypoglycemia at the level of the central nervous system or symptoms related to excess release of compensatory catecholamines. The presence of hypoglycemia, elevated insulin, proinsulin, and c-peptide levels suggest endogenous hyperinsulinism, which together with imaging findings suggestive of neuroendocrine tumor, allow establishing the diagnostic impression of Insulinoma. Cases report: Patients with neuroglycopenic symptoms, biochemical profile of hypoglycemia, endogenous hyperinsulinemia and radiological finding compatible with insulinoma are reported, who were treated by surgical resection of the tumor, with complete resolution of the initial symptoms. Conclusion: The clinical presentation, diagnosis and treatment of insulinoma represents a clinical challenge, since it is a rare pathology and the delay in diagnosis can have catastrophic consequences for the patient, stories such as permanent brain damage and death.

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Value of multi-detector computed tomography during intra-arterial infusion of contrast medium for locating insulinomas

Cited by 4 publications

References 19 publications

The diagnostic performance of contrast-enhanced ultrasound versus contrast-enhanced computed tomography for pancreatic carcinoma: a systematic review and meta-analysis

The diagnostic performance of contrast-enhanced ultrasound versus contrast-enhanced computed tomography for pancreatic carcinoma: a systematic review and meta-analysis

Hypoglycemia In Non-Diabetic Patient: Report of Two Cases of Insulinoma

Hypoglycemia in Non-Diabetic Patient: Report of Two Cases of Insulinoma

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