Value of plasma calcium, phosphate, and alkaline phosphatase measurements in the diagnosis of histological osteomalacia

Peach, Hedley G.; Compston, Juliet; Vedi, S.; Horton, L. W. L.

doi:10.1136/jcp.35.6.625

Cited by 67 publications

(35 citation statements)

References 9 publications

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“…Plasma ALP activity appears to be a sensitive single test in the past which acceptably predicts the presence or absence of histological osteomalacia [20]. We found that the ALP levels were significantly correlated with ASDAS-CRP and bone turnover biomarkers.…”

Section: Discussion:-supporting

confidence: 53%

Correlation of Vitamin D Deficiency and Sub-Clinical Osteomalacia in Axial Spondyloarthropathy.

Virdi¹,

Singh²,

Kaur³

et al. 2017

IJAR

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Introduction:Recently vitamin D deficiency has been linked to autoimmune, inflammatory and carcinogenic diseases. In autoimmune diseases, vitamin D deficiency might be associated with risk of both susceptibility and severity of the bone mineral density. Objective: Our study aims at finding vitamin D deficiency in axial spondyloarthropathy and its effect on bone integrity. Material: We compared 95 axial spondyloarthropathy patients and 75 control patients regarding Vit-D levels, bone markers, CRP, ALP, PTH, BMD and sunshine exposure. Conclusion:We conclude significant correlation between vitamin D deficiency and axial spondyloarthropathy and significantly lower femoral neck T and Z scores in BMD than controls.

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Section: Discussion:-supporting

confidence: 53%

Correlation of Vitamin D Deficiency and Sub-Clinical Osteomalacia in Axial Spondyloarthropathy.

Virdi¹,

Singh²,

Kaur³

et al. 2017

IJAR

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“…Elevated alkaline phosphatase is a useful biochemical test to screen for osteomalacia in celiacs, as it is in the general population [39,95,96]. Elevated alkaline phosphatase is also independently associated with clinical features of malabsorption in adults newly diagnosed with celiac disease [39].…”

Section: Metabolic Bone Disease and Fracture Riskmentioning

confidence: 99%

Risk of morbidity in contemporary celiac disease

Lewis

Holmes

2010

Expert Review of Gastroenterology & Hepatology

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Celiac disease is one of the most common chronic diseases encountered in the Western world with a serological prevalence of approximately 1%. Since it is so common, much comorbidity will occur either as associations or simply by chance, or as complications of the disorder. Many of the published studies purporting to establish the frequency of these occurrences have been limited by factors such as the source and number of patients considered, choice of control groups and ascertainment bias. Recent epidemiological studies have attempted to minimize these sources of error and provide more reliable information. Autoimmune diseases constitute clinically important associations, of which Type 1 diabetes mellitus and thyroid disorders are the most important. Several liver disorders, including primary biliary cirrhosis and primary sclerosing cholangitis, are also associated. The frequency of malignant complications of celiac disease is much lower than earlier studies have indicated, with lymphoma increased by approximately fivefold and the absolute number of tumors is small. The increase in fracture risk in celiac disease is only modest. Although neurological and psychiatric conditions affect celiac patients, no disorder specifically associated with celiac disease has been identified. Reproductive problems have been overexaggerated. It is important that these co-morbidities are recognized because if not, symptoms will be falsely attributed to deliberate or inadvertent ingestion of gluten, rather than prompt a search for a second diagnosis. Furthermore, in a patient with an established diagnosis that is considered falsely to account for the whole clinical picture, celiac disease is likely to remain undetected.

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“…It is essentially a histological diagnosis and may exist in the absence of biochemical and radiological abnormalities (21). It is characterized by an impairment of bone mineralization.…”

Section: Histomorphometric Findings In Clinical Disorders Osteomalaciamentioning

confidence: 99%

Bone histomorphometry: a concise review for endocrinologists and clinicians

Kulak

Dempster

2010

Arq Bras Endocrinol Metab

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SummaryBone histomorphometry is a quantitative histological examination of an undecalcified bone biopsy performed to obtain quantitative information on bone remodeling and structure. Labeling agents taken before the procedure deposit at sites of bone formation allowing a dynamic analysis. Biopsy is indicated to make the diagnosis of subclinical osteomalacia, to characterize the different forms of renal osteodystrophy and to elucidate cases of unexplained skeletal fragility. Bone histomorphometric parameters are divided into structural and remodeling subgroups, with the latter being subdivided into static and dynamic categories. Metabolic bone disorders such as osteomalacia, hyperparathyroidism, hypothyroidism, osteoporosis and renal osteodystrophy display different histomorphometric profiles. Antiresorptive and anabolic drugs used for the treatment of osteoporosis also induce characteristic changes in the bone biopsy. Bone histomorphometry is an important research tool in the field of bone metabolism and provides information that is not available by any other investigative approach. Arq Bras Endocrinol Metab. 2010;54(2):87-98 Keywords Bone histomorphometry; metabolic bone diseases; bone biopsy; bone structure; osteoporosis drugs Sumário Histomorfometria óssea é uma avaliação histológica quantitativa de uma biópsia óssea calcificada realizada para obter informação sobre a remodelação e a estrutura óssea. Uma análise dinâmica é possível quando substâncias que fazem a marcação do osso são tomadas antes do procedimento e se depositam no local de formação óssea. A biópsia é indicada para diagnós-tico de osteomalácia, diferentes formas de osteodistrofia renal e nos casos não explicados de fragilidade esquelética. O preparo e a análise das amostras necessitam de um laboratório especializado. A histomorfometria avalia parâmetros estruturais e de remodelação óssea, sendo o último subdividido em estático e dinâmico. Doenças osteometabólicas como osteomalácia, hiperparatireoidismo, hipoparatireoidismo, osteoporose e osteodistrofia renal apresentam parâmetros histomorfométricos distintos. Medicações antirreabsortivas e anabólicas usadas no tratamento da osteoporose também induzem alterações características na biópsia óssea. A histomorfometria óssea é uma ferramenta importante no metabolismo ósseo e oferece informação que não é possível por nenhum outro método diagnóstico. Arq Bras Endocrinol Metab. 2010;54(2):87-98

show abstract

Value of plasma calcium, phosphate, and alkaline phosphatase measurements in the diagnosis of histological osteomalacia

Cited by 67 publications

References 9 publications

Correlation of Vitamin D Deficiency and Sub-Clinical Osteomalacia in Axial Spondyloarthropathy.

Correlation of Vitamin D Deficiency and Sub-Clinical Osteomalacia in Axial Spondyloarthropathy.

Risk of morbidity in contemporary celiac disease

Bone histomorphometry: a concise review for endocrinologists and clinicians

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