Value of preoperative gastroscopic carbon nanoparticles labeling in patients undergoing laparoscopic radical gastric cancer surgery

Feng, Yun; Yang, Kui; Sun, Huanhuan; Liu, Yaping; Zhang, Dan; Zhao, Yan; Shi, Wen; Lu, Guifang; Zhang, Zhiyong; Jia, Ai; He, Shuixiang

doi:10.1016/j.suronc.2021.101628

Cited by 14 publications

(17 citation statements)

References 21 publications

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“…The usage of CNSI probably accounted for the consequence. As reported before, CNSI improved the quantity and accuracy of lymph nodes collected significantly due to their excellent lymphatic system targeting and retention capacities [ 9 , 16 ]. Thus, it has been widely applied in lymph node detection.…”

Section: Discussionmentioning

confidence: 83%

“…Whether in the LG or RAG group, the average number of detected lymph nodes was close to 30 in our research, which was far exceeding the number specified in the guidelines. Although the injecting methods of CNSI are divided into submucosal and subserosal [ 9 , 16 ], we adopted submucosal injections 1 day before surgery since a waiting time of over 6 h seemed to be more appropriate for imaging [ 17 ]. Whether in robotic-assisted or laparoscopic gastrectomy, the lymph nodes in the surgical field were all stained black, which was more convenient for the identification and detection of lymph nodes for precise N staging.…”

Section: Discussionmentioning

confidence: 99%

“…However, numerous previous clinical researches failed to identify the differences between laparoscopic and robotic-assisted gastrectomies in terms of outcomes [13][14][15]. Additionally, although CNSI does a favor to LN detection and better perioperative outcomes [16,17], there is no clinical research evaluating the distinctions between these two surgical approaches with the assistance of CNSI. The current study is purposed to investigate the perioperative outcomes of laparoscopic gastrectomy and robotic-assisted gastrectomy in gastric cancer patients.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of short-term outcomes between robotic-assisted and laparoscopic gastrectomy guided by carbon nanoparticle suspension injection in gastric cancer

Wang

et al. 2022

World J Surg Onc

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Background The clinical application of robotic-assisted gastrectomy remains controversial, especially as clinical studies of this operation navigated by carbon nanoparticle suspension injection (CNSI) have not been conducted. This study aims to assess the perioperative safety and efficacy of CNSI-guided robotic-assisted gastrectomy in patients with gastric cancer by focusing on short-term outcomes. Methods A retrospective analysis of patients who underwent CNSI-guided laparoscopic or robotic-assisted gastrectomy with a pathological diagnosis of gastric cancer was conducted. Data on demographics, surgical management, clinical-pathological results and short-term outcomes were compared among the groups. Results A total of 126 eligible patients were separated into the robotic-assisted gastrectomy (RAG) group (n = 16) and the laparoscopic gastrectomy (LG) group (n = 110) in total. The operation time of the RAG group is longer than the LG group (p = 0.0000). When it comes to perioperative and short-term complications, there exists no statistical difference between the two groups. Conclusion The time required for CNSI-guided robotic-assisted gastrectomy is longer than that for CNSI-guided laparoscopic gastrectomy. CNSI-guided robotic-assisted gastrectomy is safe and effective.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of short-term outcomes between robotic-assisted and laparoscopic gastrectomy guided by carbon nanoparticle suspension injection in gastric cancer

Wang

et al. 2022

World J Surg Onc

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“…CNSI is the most suitable type of carbon particle for LN detection. Appropriate submucosal administration times are reported to range from 6 h to 2 days [ 93 , 94 ]. A waiting time of less than 6 h might lead to poor imaging effects, while injecting 1 to 2 days before surgery showed similar efficiencies [ 98 ].…”

Section: Tracers In Gc Surgerymentioning

confidence: 99%

Tracers in Gastric Cancer Surgery

Zhu

et al. 2022

Cancers

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The treatment of gastric cancer mainly depends on radical gastrectomy. Determination of appropriate surgical margins and adequate lymph node (LN) resection are two major surgical steps that directly correlate with prognosis in gastric cancer. Due to the expanding use of minimally invasive procedures, it is no longer possible to locate tumors and LNs through touch. As an alternative, tracers have begun to enter the field due to their capacities for intraoperative visualization. Herein, we summarize the application of contemporary tracers in gastric cancer surgery, including isosulfan blue, methylene blue, patent blue, indocyanine green, carbon particles, and radioactive tracers. Their mechanisms, administration methods, detection efficiency, and challenges, as well as perspectives on them, are also outlined.

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“…proved to supply surgeons with improved inspection of the complex perigastric anatomy during laparoscopic surgery. Studies have shown that carbon nanoparticle lymphatic mapping technology increases the number of LNs harvested and realizes tumor localization (20)(21)(22). Drawbacks exist, however, that once the carbon nanoparticles leaked into the abdominal cavity, the whole surgical field would be dyed black, thus interfering with the vision of the surgery field and increasing operation difficulty.…”

Section: Introductionmentioning

confidence: 99%

Clinical Application of Indocyanine Green Fluorescence Technology in Laparoscopic Radical Gastrectomy

et al. 2022

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BackgroundThis study aimed to observe the application and evaluate the feasibility and safety of indocyanine green (ICG) fluorescence technology in laparoscopic radical gastrectomy (LRG).MethodsPatients who underwent LRG & D2 lymphadenectomy at Qilu Hospital of Shandong University were included between January 2018 and August 2019. According to whether endoscopic injection of ICG was performed, patients were assigned to the ICG group (n=107) and the control group (n=88). The clinicopathologic features, retrieved lymph nodes, postoperative recovery, and follow-up data were compared between the two groups.ResultsBaseline characteristics are comparable. The ICG group had a significantly larger number of lymph nodes retrieved (49.55 ± 12.72 vs. 44.44 ± 10.20, P<0.05), shorter total operation time (min) (198.22 ± 13.14 vs. 202.50 ± 9.91, P<0.05), shorter dissection time (min) (90.90 ± 5.34 vs. 93.74 ± 5.35, P<0.05) and less blood loss (ml) (27.51 ± 12.83 vs. 32.02 ± 17.99, P<0.05). The median follow-up time was 29.0 months (range 1.5-43.8 months), and there was no significant difference between the ICG group and the control group in 2-year OS (87.8% vs. 82.9%, P>0.05) or DFS (86.0% vs. 80.7%, P>0.05).ConclusionsICG fluorescence technology in laparoscopic radical gastrectomy has advantages in LN dissection, operation time, and intraoperative blood loss. The 2-year OS and 2-year DFS rates between the two groups were comparable. In conclusion, ICG fluorescence technology is feasible and safe.

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Value of preoperative gastroscopic carbon nanoparticles labeling in patients undergoing laparoscopic radical gastric cancer surgery

Cited by 14 publications

References 21 publications

Comparison of short-term outcomes between robotic-assisted and laparoscopic gastrectomy guided by carbon nanoparticle suspension injection in gastric cancer

Comparison of short-term outcomes between robotic-assisted and laparoscopic gastrectomy guided by carbon nanoparticle suspension injection in gastric cancer

Tracers in Gastric Cancer Surgery

Clinical Application of Indocyanine Green Fluorescence Technology in Laparoscopic Radical Gastrectomy

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