Value of spectral detector CT for pretherapeutic, locoregional assessment of esophageal cancer

Zopfs, David; Hokamp, Nils Große; Reimer, Robert Peter; Bratke, Grischa; Maintz, David; Bruns, Christiane; Mallmann, Christoph; Persigehl, Thorsten; Haneder, Stefan; Lennartz, Simon

doi:10.1016/j.ejrad.2020.109423

Cited by 17 publications

(12 citation statements)

References 32 publications

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“…The results were judged based on the percentage of positive cells and the intensity of staining (10). (I) The positive standard was the bleeding of brown or brown particles in the nucleus or cytoplasm.…”

Section: Ctbp2 and P16 Ink4a Detectionmentioning

confidence: 99%

Correlation between microvessel density (MVD) and multi-spiral CT (MSCT) perfusion parameters of esophageal cancer lesions and the diagnostic value of combined CtBP2 and P16INK4A

Dong

Feng

et al. 2021

J Gastrointest Oncol

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Background: This article aims to analyze the correlation between microvessel density (MVD) and multispiral CT(MSCT) perfusion parameters of esophageal cancer lesions, and the diagnostic value of combining C-terminal binding protein 2 (CtBP2) and P16 inhibitor of cyclin-dependent kinase 4a (P16 INK4A ). Methods: A total of 42 cases of normal esophageal mucosa tissues >5 cm from the cancer tissue were selected as the control group. The expression levels of CtBP2 and P16 INK4A and the values of MSCT perfusion parameters and MVD were compared in the control group and esophageal cancer group. SP immunohistochemical staining was used to detect protein expression levels of CtBP2 and P16 INK4A . The Pearson method was used to analyze the differences and pertinence of MSCT perfusion parameters and MVD in the control group and esophageal cancer group. The receiver operating characteristic (ROC) curve was used to calculate the diagnostic value of CtBP2 and P16 INK4A combined with MVD and MSCT perfusion parameters in esophageal cancer.Results: The positive expression rate of P16 INK4A in the esophageal cancer group was significantly lower than that in the control group. The positive expression rates of CtBP2, blood volume (BV), mean transit time (MTT), surface permeability (permeability surface, PS), and MVD values were significantly higher than those of the control group (P<0.05). There was no significant difference in blood flow (BF) value between the 2 groups (P>0.05). The BF value of the tumor invading the fibrous membrane was significantly higher than that of the non-invading fibrous membrane (P<0.05), and the PS and MVD values of the patients with lymph node metastasis were higher than those without lymph node metastasis (P<0.05). The MSCT perfusion parameters BF and BV were significantly positively correlated with MVD (P<0.05), while MTT, PS, and MVD were not significantly correlated (P>0.05). ROC results showed that the areas under curve (AUC) of CtBP2, P16 INK4A , and MSCT were 0.625, 0.747, and 0.812, respectively. However, the area under the combined detection curve was larger, at 0.869. Conclusions: MSCT perfusion imaging of esophageal cancer lesions can indirectly reflect the angiogenesis of esophageal cancer, and the combination of CtBP2 and P16 INK4A can effectively improve the diagnostic efficiency of the disease.

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Section: Ctbp2 and P16 Ink4a Detectionmentioning

confidence: 99%

Correlation between microvessel density (MVD) and multi-spiral CT (MSCT) perfusion parameters of esophageal cancer lesions and the diagnostic value of combined CtBP2 and P16INK4A

Dong

Feng

et al. 2021

J Gastrointest Oncol

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“…Although, in our study, a proportion of patients were overestimated or underestimated between T2 and T3, our results show that the mass margins were significantly clearer and the lesion of mucosal layer is more obvious in MEI (+) 40 keV than in PEI. DECT application in EC patients also can clearly depict the addition structure (such as lymph node or vascular) of EC [ 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the noise-optimized virtual monoenergetic images (MEI (+)) derived from dual-energy CT (DECT) are widely used to improve the SNR and CNR, which was superior tumor visibility to polyenergetic images (PEI) [ 9 – 11 ]. Zopfs et al demonstrated that virtual monoenergetic images at 40–60 keV improve qualitative assessment of the EC lesion and depiction of lymph nodes and vessels at pretherapeutic [ 12 ], while this study was based on adenocarcinoma of the esophagogastric junction and did not explore the clinical diagnostic value of DECT in preoperative T staging of EC. On the other hand, DECT can provide multiple quantitative information about tissue composition, overcoming the limitations of attenuation-based conventional single-energy CT imaging [ 13 ].…”

Section: Introductionmentioning

confidence: 98%

Evaluation of optimal monoenergetic images acquired by dual-energy CT in the diagnosis of T staging of thoracic esophageal cancer

Cheng

Liu

et al. 2023

Insights Imaging

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Objectives The purpose of our study was to objectively and subjectively assess optimal monoenergetic image (MEI (+)) characteristics from dual-energy CT (DECT) and the diagnostic performance for the T staging in patients with thoracic esophageal cancer (EC). Methods In this retrospective study, patients with histopathologically confirmed EC who underwent DECT from September 2019 to December 2020 were enrolled. One standard polyenergetic image (PEI) and five MEI (+) were reconstructed. Two readers independently assessed the lesion conspicuity subjectively and calculated the contrast-to-noise ratio (CNR) and the signal-to-noise ratio (SNR) of EC. Two readers independently assessed the T stage on the optimal MEI (+) and PEI subjectively. Multiple quantitative parameters were measured to assess the diagnostic performance to identify T1-2 from T3-4 in EC patients. Results The study included 68 patients. Subjectively, primary tumor delineation received the highest ratings in MEI (+) 40 keV of the venous phase. Objectively, MEI (+) images showed significantly higher SNR compared with PEI (p < 0.05), peaking at MEI (+) 40 keV in the venous phase. CNR of tumor (MEI (+) 40 keV -80 keV) was all significantly higher than PEI in arterial and venous phases (p < 0.05), peaking at MEI (+) 40 keV in venous phases. The agreement between MEI (+) 40 keV and pathologic T categories was 81.63% (40/49). Rho values in venous phases had excellent diagnostic efficiency for identifying T1-2 from T3-4 (AUC = 0.84). Conclusions MEI (+) reconstructions at low keV in the venous phase improved the assessment of lesion conspicuity and also have great potential for preoperative assessment of T staging in patients with EC.

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“…At present, there are more and more studies on the combination of various imaging technologies for evaluating the curative effect and prognosis of tumors. As a technology characterized by displaying organ function and metabolic state, CT can not only observe the thickness of the esophageal wall and the interface at the wall before and after radiotherapy, but also determine the extent and degree of extra-esophageal cavity invasion, and the lymph node metastasis and distant metastasis can also be identified ( 15 ). CT is of great value in evaluating the extension of esophageal cancer.…”

Section: Discussionmentioning

confidence: 99%

Application Value of Gastroenterography Combined With CT in the Evaluation of Short-Term Efficacy and Prognosis in Patients With Esophageal Cancer Radiotherapy

Xue

Linning

et al. 2022

Front. Surg.

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PurposeTo observe the application value of gastroenterography combined with CT in the evaluation of short-term efficacy and prognosis in patients with esophageal cancer radiotherapy.MethodsFrom January 2013 to December 2020, the clinical data of 207 patients with esophageal cancer treated by radiotherapy in our hospital were collected retrospectively. All patients received gastroenterography and CT examination before and after radiotherapy, and the patients were followed-up for 1 year, and the evaluation value of their short-term efficacy and prognosis was observed.ResultsAfter radiotherapy, the length diameter, short diameter, and volume of the lymph node were lower than those before radiotherapy (p < 0.05), but the maximum tube wall thickness had no significant difference (p > 0.05). The length diameter, short diameter, and volume of the lymph node, and the maximum tube wall thickness in the good efficacy group and the good prognosis group were lower, and the objective response rate in the good prognosis group was higher (p < 0.05). The area under the curve (AUC) of the length diameter, short diameter, and volume of the lymph node to evaluate the short-term efficacy of patients with esophageal cancer was 0.738, 0.705, and 0.748, respectively, and the AUC to evaluate the prognosis of patients with esophageal cancer was 0.751, 0.776, and 0.791, respectively.ConclusionGastroenterography combined with CT has a good application value in the evaluation of short-term efficacy and prognosis in patients with esophageal cancer radiotherapy.

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Value of spectral detector CT for pretherapeutic, locoregional assessment of esophageal cancer

Cited by 17 publications

References 32 publications

Correlation between microvessel density (MVD) and multi-spiral CT (MSCT) perfusion parameters of esophageal cancer lesions and the diagnostic value of combined CtBP2 and P16INK4A

Correlation between microvessel density (MVD) and multi-spiral CT (MSCT) perfusion parameters of esophageal cancer lesions and the diagnostic value of combined CtBP2 and P16INK4A

Evaluation of optimal monoenergetic images acquired by dual-energy CT in the diagnosis of T staging of thoracic esophageal cancer

Application Value of Gastroenterography Combined With CT in the Evaluation of Short-Term Efficacy and Prognosis in Patients With Esophageal Cancer Radiotherapy

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