Vanadium and Melanoma: A Systematic Review

Amante, Cristina; Sousa‐Coelho, Ana Luísa De; Aureliano, Manuel

doi:10.3390/met11050828

Cited by 48 publications

(24 citation statements)

References 86 publications

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“…Additionally, it is important to mention that recent work from Aureliano's group about melanoma anticancer activity of a variety of vanadium compounds [73] and potential anti-SARS-CoV-2 activity of vanadium compounds by Scior et al [74], present a promising future for vanadium compounds as metallodrugs.…”

Section: Discussionmentioning

confidence: 99%

2-Aminopyrimidinium Decavanadate: Experimental and Theoretical Characterization, Molecular Docking, and Potential Antineoplastic Activity

et al. 2021

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The interest in decavanadate anions has increased in recent decades, since these clusters show interesting applications as varied as sensors, batteries, catalysts, or new drugs in medicine. Due to the capacity of the interaction of decavanadate with a variety of biological molecules because of its high negative charge and oxygen-rich surface, this cluster is being widely studied both in vitro and in vivo as a treatment for several global health problems such as diabetes mellitus, cancer, and Alzheimer’s disease. Here, we report a new decavanadate compound with organic molecules synthesized in an aqueous solution and structurally characterized by elemental analysis, infrared spectroscopy, thermogravimetric analysis, and single-crystal X-ray diffraction. The decavanadate anion was combined with 2-aminopyrimidine to form the compound [2-ampymH]6[V10O28]·5H2O (1). In the crystal lattice, organic molecules are stacked by π–π interactions, with a centroid-to-centroid distance similar to that shown in DNA or RNA molecules. Furthermore, computational DFT calculations of Compound 1 corroborate the hydrogen bond interaction between pyrimidine molecules and decavanadate anions, as well as the π–π stacking interactions between the central pyrimidine molecules. Finally, docking studies with test RNA molecules indicate that they could serve as other potential targets for the anticancer activity of decavanadate anion.

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Section: Discussionmentioning

confidence: 99%

2-Aminopyrimidinium Decavanadate: Experimental and Theoretical Characterization, Molecular Docking, and Potential Antineoplastic Activity

et al. 2021

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“…VCs are suitable candidates in the search for novel anticancer agents, 6 insulin enhancers, 1c , 7 and antibacterial 8 and antiparasitic agents. 9 Among several VCs exhibiting insulin-enhancing properties, species with the stoichiometry V IV O(carrier) 2 /V V O 2 (carrier) 2 with carrier = maltolato (ma), 1,2-dimethyl-3-hydroxy-4(1 H )-pyridinonato (dhp), picolinato (pic), and dipicolinato (dipic) have been extensively studied.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic/Computational Characterization and the X-ray Structure of the Adduct of the V^IVO–Picolinato Complex with RNase A

et al. 2021

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The structure, stability, and enzymatic activity of the adduct formed upon the reaction of the V–picolinato (pic) complex [V IV O(pic) 2 (H 2 O)], with an octahedral geometry and the water ligand in cis to the V=O group, with the bovine pancreatic ribonuclease (RNase A) were studied. While electrospray ionization-mass spectrometry, circular dichroism, and ultraviolet–visible absorption spectroscopy substantiate the interaction between the metal moiety and RNase A, electron paramagnetic resonance (EPR) allows us to determine that a carboxylate group, stemming from Asp or Glu residues, and imidazole nitrogen from His residues are involved in the V binding at acidic and physiological pH, respectively. Crystallographic data demonstrate that the V IV O(pic) 2 moiety coordinates the side chain of Glu111 of RNase A, by substituting the equatorial water molecule at acidic pH. Computational methods confirm that Glu111 is the most affine residue and interacts favorably with the OC -6-23-Δ enantiomer establishing an extended network of hydrogen bonds and van der Waals stabilizations. By increasing the pH around neutrality, with the deprotonation of histidine side chains, the binding of the V complex to His105 and His119 could occur, with that to His105 which should be preferred when compared to that to the catalytically important His119. The binding of the V compound affects the enzymatic activity of RNase A, but it does not alter its overall structure and stability.

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“…These ROS can, in turn, further cause PTP inhibition as well as induce cytotoxicity [114,176]. Consequently, the anticancer properties of oxidovanadium complexes are well documented in the literature [111,[176][177][178]. Vanadium (IV) compounds have been shown to inhibit cell adhesion to the extracellular matrix and cell migration in osteosarcoma cells [179].…”

Section: Compounds Action Referencementioning

confidence: 99%

Targeting Breast Cancer and Their Stem Cell Population through AMPK Activation: Novel Insights

Uprety

Abrahamse

2022

Cells

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Despite some significant advancements, breast cancer has become the most prevalent cancer in the world. One of the main reasons for failure in treatment and metastasis has been attributed to the presence of cancer initiating cells—cancer stem cells. Consequently, research is now being focussed on targeting cancer cells along with their stem cell population. Non-oncology drugs are gaining increasing attention for their potent anticancer activities. Metformin, a drug commonly used to treat type 2 diabetes, is the best example in this regard. It exerts its therapeutic action by activating 5′ adenosine monophosphate-activated protein kinase (AMPK). Activated AMPK subsequently phosphorylates and targets several cellular pathways involved in cell growth and proliferation and the maintenance of stem-like properties of cancer stem cells. Therefore, AMPK is emerging as a target of choice for developing effective anticancer drugs. Vanadium compounds are well-known PTP inhibitors and AMPK activators. They find extensive applications in treatment of diabetes and obesity via PTP1B inhibition and AMPK-mediated inhibition of adipogenesis. However, their role in targeting cancer stem cells has not been explored yet. This review is an attempt to establish the applications of insulin mimetic vanadium compounds for the treatment of breast cancer by AMPK activation and PTP1B inhibition pathways.

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Vanadium and Melanoma: A Systematic Review

Cited by 48 publications

References 86 publications

2-Aminopyrimidinium Decavanadate: Experimental and Theoretical Characterization, Molecular Docking, and Potential Antineoplastic Activity

2-Aminopyrimidinium Decavanadate: Experimental and Theoretical Characterization, Molecular Docking, and Potential Antineoplastic Activity

Spectroscopic/Computational Characterization and the X-ray Structure of the Adduct of the V^IVO–Picolinato Complex with RNase A

Targeting Breast Cancer and Their Stem Cell Population through AMPK Activation: Novel Insights

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Vanadium and Melanoma: A Systematic Review

Cited by 48 publications

References 86 publications

2-Aminopyrimidinium Decavanadate: Experimental and Theoretical Characterization, Molecular Docking, and Potential Antineoplastic Activity

2-Aminopyrimidinium Decavanadate: Experimental and Theoretical Characterization, Molecular Docking, and Potential Antineoplastic Activity

Spectroscopic/Computational Characterization and the X-ray Structure of the Adduct of the VIVO–Picolinato Complex with RNase A

Targeting Breast Cancer and Their Stem Cell Population through AMPK Activation: Novel Insights

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Product

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Spectroscopic/Computational Characterization and the X-ray Structure of the Adduct of the V^IVO–Picolinato Complex with RNase A