Vanadium(V) complexes with hydrazides and their spectroscopic and biological properties

Abstract

The present study explores the synthesis and inhibitory potential of vanadium(V) complexes of hydrazides (1c-12c) against oxidative enzymes including xanthine oxidase and lipoxygenase (LOX). In addition, non-enzymatic radical scavenging activities of these complexes were also determined. On the basis of spectral, elemental and physical data, synthesized vanadium(V) complexes are tentatively assigned to have an octahedral geometry with two hydrazide ligands and two oxo groups forming a negatively charged sphere complex with ammonium as counter ion. This is further verified by the conductivity studies of the complexes. Results show that hydrazide ligands (1-12) and their respective vanadium(V) complexes (1c-12c) posses scavenging and inhibition potential against DPPH and LOX, respectively. However, contrary to that uncoordinated ligands showed no activity against nitric oxide, superoxide and xanthine oxidase whereas their complexes showed varying degree of activity. These studies indicate that geometry of complex, nature and position of substituent groups play a vital role in scavenging and inhibition potential of these compounds.

Cytotoxic, antiglycation and carbonic anhydrase inhibition studies of chromium(III)-aroylhydrazine complexes

“…All of the aroylhydrazine ligands ( Figure 1) have been synthesized and characterized previously. The physical and analytical data of these synthesized ligands have been described [7][8][9][10][11][12][13][14][15]. Aroylhydrazine ligands (1-7) were re synthesized here from previous method [13].…”

“…Synthesis and structural studies of aroylhydrazine ligands (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) have reported previously [7][8][9][10][11][12][13][14][15]. Chromium(III)-aroylhydrazine complexes (8a-12a) were discussed in reference [13] while remaining chromium(III) complexes (1a-7a) with aroylhydrazine ligands (1-7) are specified in Figure 1 and Scheme 1.…”

“…So it is necessary to investigate new non-toxic chromium(III) complexes. Moreover, ligands such as aroylhydrazines have also an enormous biologically importance and their activities are known to be more enhanced after complexation with certain metal ions [7][8][9][10][11][12][13][14][15].…”