Vancomycin: An analysis and evaluation of eight population pharmacokinetic models for clinical application in general adult population
Alexandre Duong,
Ahmed El Gamal,
Véronique Bilodeau
et al.
Abstract:IntroductionBased on the recent guidelines for vancomycin therapeutic drug monitoring (TDM), the area under the curve to minimum inhibitory concentration ratio was to be employed combined with the usage of population pharmacokinetic (popPK) model for dosing adaptation. Yet, deploying these models in a clinical setting requires an external evaluation of their performance.ObjectivesThis study aimed to evaluate existing vancomycin popPK models from the literature for the use in TDM within the general patient popu… Show more
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