1988
DOI: 10.1007/bf03259891
|View full text |Cite
|
Sign up to set email alerts
|

Vancomycin Ototoxicity and Nephrotoxicity

Abstract: Vancomycin has been in clinical use as a potent antistaphylococcal antibiotic for over 30 years. Most reports of ototoxicity and nephrotoxicity have been associated with early, relatively impure, formulations of vancomycin. This paper reviews the literature concerning vancomycin ototoxocity and nephrotoxicity and the evidence for their correlation with the therapeutic serum concentration range. There have been 28 reports of vancomycin-associated ototoxicity published in the medical literature since 1958. It re… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

3
84
0

Year Published

1997
1997
2023
2023

Publication Types

Select...
6
1
1
1

Relationship

0
9

Authors

Journals

citations
Cited by 124 publications
(87 citation statements)
references
References 39 publications
3
84
0
Order By: Relevance
“…The treatment of extremity trauma can be complicated by polymicrobial infections and systemic antibiotic treatment that can be toxic to organ systems [6,11,13,35,56,58]. Localized antimicrobial drug delivery systems, including biomaterial carrier matrices and coatings on implants, have become a focus to combat biofilm formation and infection for both preventive and treatment strategies [1,7,13,27,29,43,49,63,64].…”
Section: Discussionmentioning
confidence: 99%
“…The treatment of extremity trauma can be complicated by polymicrobial infections and systemic antibiotic treatment that can be toxic to organ systems [6,11,13,35,56,58]. Localized antimicrobial drug delivery systems, including biomaterial carrier matrices and coatings on implants, have become a focus to combat biofilm formation and infection for both preventive and treatment strategies [1,7,13,27,29,43,49,63,64].…”
Section: Discussionmentioning
confidence: 99%
“…More than 50% of the cases were identified within the first six years of VAN use when the product was relatively impure [7]. As manufacturing processes improved and VAN was purified, nephrotoxicity became less common [8], and contemporary preparations seemed to nearly eliminate the original adverse events.…”
Section: Discussionmentioning
confidence: 99%
“…As a result of elevated dosage, serum concentrations may increase and it may lead to toxicity [62,63,64,65].Vancomycin increases risk of nephrotoxicity in human with drugs such as aminoglycosides, amphotericin, capreomycin,cyclosporine,cisplatin,colistimethate, polymyxins and tacrolimus [37].There are veterinary indications for above drugs [66,67].Therefore, it is desirable to investigate the adverse effects when above drugs are administered concurrently with vancomycin in animals.…”
Section: Adverse Effect Of Vancomycinmentioning
confidence: 99%