Vanin-1; a potential biomarker for nephrotoxicant-induced renal injury

Hosohata, Keiko; Ando, Hitoshi; Fujiwara, Yoko; Fujimura, Akio

doi:10.1016/j.tox.2011.08.019

Cited by 66 publications

(68 citation statements)

References 36 publications

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“…In a recent study, we reported that urinary concentration of vanin-1 elevated before the conventional markers changed in rats with nephrotoxicant-induced renal tubular injury (Hosohata et al, 2011). Vanin-1, an epithelial glycosylphos-phatidylinositol-anchored pantetheinase (Aurrand-Lions et al, 1996;Pitari et al, 2000), participates in the response to oxidative stress in vivo (Berruyer et al, 2004).…”

Section: N-acetyl-␤-d-glucosaminidase (Nag)mentioning

confidence: 99%

Urinary Vanin-1 As a Novel Biomarker for Early Detection of Drug-Induced Acute Kidney Injury

Hosohata

Ando²,

Fujimura³

2012

J Pharmacol Exp Ther

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Drug-induced nephrotoxicity is a serious problem in patients with hospital-acquired acute kidney injury (AKI). A new renal biomarker is needed because traditional markers are not sensitive for early detection of drug-induced AKI. In a recent study, we demonstrated that vanin-1 is a novel candidate biomarker of nephrotoxicant-induced kidney injury. The objective of the present study is to determine whether the increase in urinary vanin-1 is detected before the elevations of serum creatinine or urinary N-acetyl-␤-glucosaminidase (NAG), kidney injury molecule-1 (Kim-1), and neutrophil gelatinase-associated lipocalin (NGAL) in the two well established animal models of drug-induced AKI. After the administration of a higher dose of cisplatin (10 mg/kg, a single intraperitoneal dose) or gentamicin (120 mg/kg per day, once daily intraperitoneal dose for 9 days), urinary vanin-1 was detected earlier than the other biomarkers. In rats treated with a lower dose of cisplatin (5 mg/kg, a single intraperitoneal dose) or gentamicin (40 mg/kg per day, once daily intraperitoneal dose for 9 days), serum creatinine and urinary NAG were not changed throughout the study period, whereas urinary vanin-1, Kim-1, and NGAL were significantly increased. The renal vanin-1 protein levels were significantly decreased in rats treated with the higher dose of cisplatin on day 5 and gentamicin on day 9, and the immunofluorescence analyses confirmed that vanin-1 immunoreactivity in tubular cells was reduced with the time after the dose of cisplatin, indicating that urinary vanin-1 was leaked from tubular cells. These results suggest that, compared with urinary Kim-1 and NGAL, urinary vanin-1 is an earlier and equally sensitive biomarker for drug-induced AKI.

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Section: N-acetyl-␤-d-glucosaminidase (Nag)mentioning

confidence: 99%

Urinary Vanin-1 As a Novel Biomarker for Early Detection of Drug-Induced Acute Kidney Injury

Hosohata

Ando²,

Fujimura³

2012

J Pharmacol Exp Ther

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“…[11][12][13] In one study, serum vanin-1 measurement was suggested as a renal injury biomarker. 11 In our study, while serum vanin-1 was elevated at the postoperative first and sixth months, vanin-1 levels were low in renal failure patients. Serum creatinine levels were no different in the first and sixth months after Tx.…”

Section: Discussionmentioning

confidence: 99%

“…11 Fugmann and associates investigated probable disease markers in an animal model of diabetic nephropathy. 13 In that study, rats were perfused with a reactive ester derivative of biotin at various times after streptozotocin treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, Vanin-1−/− animals are more resistant to exposure to oxidative stress. 11,12 Currently, urinary and serum levels of vanin-1 have been elevated in the ethylene glycol-exposed rats, although synchronous serum levels of creatinine and blood urea nitrogen and urinary N-acetyl-beta-D-glucosaminidase did not significantly increase. Therefore, it is hoped that vanin-1 is a useful biomarker for nephrotoxicantinduced renal tubular injury in comparison to classic markers.…”

Section: Introductionmentioning

confidence: 92%

“…Therefore, it is hoped that vanin-1 is a useful biomarker for nephrotoxicantinduced renal tubular injury in comparison to classic markers. 11 We aimed to evaluate changes in serum vanin-1 levels in recipients without rejection before and after transplant.…”

Section: Introductionmentioning

confidence: 99%

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Untitled

2014

Exp Clin Transplant

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Objectives: Vascular noninflammatory molecule 1 is a plasma membrane enzyme, also known as pantetheinase. It has been shown that vascular noninflammatory molecule 1 urinary and serum concentrations of vascular noninflammatory molecule 1 increase in nephrotoxicant-induced renal injury before classic markers. Tacrolimus and cyclosporine used as immunosuppressive agents are nephrotoxic drugs. This study sought to investigate alterations of vascular noninflammatory molecule 1 levels after a kidney transplant. Materials and Methods: This study included 28 renal allograft recipients without acute rejection. Before transplant, and the first and sixth months after the transplant, vascular noninflammatory molecule 1 and creatinine levels were measured in renal transplant recipients using enzyme-linked immunosorbent assay and spectrophotometric methods. Results: During the first month after transplant, we observed a significant increase in vascular noninflammatory molecule 1 levels compared with previous levels (P < .0001). Also, during the sixth month, vascular noninflammatory molecule 1 levels were higher than values previously taken (P < .01), although they were lower compared with the first month values (P = .004). No correlation was found between vascular noninflammatory molecule 1 and creatinine before transplant or during the first and sixth months after transplant. When the patients were divided into subgroups according to the immunosuppressive drugs used, in tacrolimustreated patients, serum vascular noninflammatory molecule 1 levels were no different from the cyclosporine-administered levels measured at 3 different times. Conclusions: We conclude that serum vascular noninflammatory molecule 1 levels may be low in the end-stage renal failure and transiently increase after transplant owing to transient renal function deterioration, which does not lead to elevation of serum creatinine levels in renal transplant patients.

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Early detection of renal injury using urinary vanin‐1 in rats with experimental colitis

Hosohata

Ando

Fujimura

2013

J of Applied Toxicology

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Renal complications are often detected in patients with inflammatory bowel disease (IBD). Because conventional markers such as serum creatinine and β2-microglobulin are not sensitive and/or specific, a new renal biomarker is needed. We have recently identified urinary vanin-1 as an early biomarker for the detection of nephrotoxicant-induced renal injury. In this study, we compared the usefulness of urinary vanin-1 with other newly developed biomarkers [urinary monocyte chemoattractant protein-1 (MCP-1), kidney injury molecule-1 (Kim-1) and N-acetyl-beta-D-glucosaminidase (NAG)] for the detection of renal complications in rats with experimental colitis. On day 2 after intracolonic injection of 2,4,6-trinitrobenzene sulfonic acid (TNBS), male Wistar rats developed not only colitis, but histologically evident renal injury. Urinary vanin-1 started to elevate on day 1, whereas serum creatinine and urinary excretions of glucose, total protein, albumin, Kim-1, MCP-1 and NAG significantly increased only on day 2. The mRNA expressions of vanin-1 and Kim-1 significantly increased in the kidney, but not in the colon. In addition, vanin-1 did not appear in the blood. On the other hand, colonic mRNA expression and the serum concentration of MCP-1 were significantly higher in the TNBS-treated rats than in the control animals. These results suggest that, in contrast to MCP-1, urinary vanin-1 and Kim-1 mainly originated from the kidney rather than the colon in this model. Compared with Kim-1 and MCP-1, vanin-1 might be an earlier biomarker for the detection of renal injury in rats with experimental colitis.

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Vanin-1; a potential biomarker for nephrotoxicant-induced renal injury

Cited by 66 publications

References 36 publications

Urinary Vanin-1 As a Novel Biomarker for Early Detection of Drug-Induced Acute Kidney Injury

Urinary Vanin-1 As a Novel Biomarker for Early Detection of Drug-Induced Acute Kidney Injury

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Early detection of renal injury using urinary vanin‐1 in rats with experimental colitis

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