Vaping and Respiratory Viruses: The End for ENDS?

Tan, Kai Sen; Wang, De Yun

doi:10.1165/rcmb.2020-0501ed

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Finally, the ongoing COVID-19 pandemic may present an opportunity to develop impactful and timely adolescent vaping warning messages. For example, it is possible that some of the respiratory effects associated with vaping 20 , 21 could result in more severe cases of COVID-19 among adolescents who vape. For instance, a recent study found that ever use of e-cigarettes and dual use of cigarettes and e-cigarettes may increase adolescents’ likelihood of contracting COVID-19 and developing symptoms, 22 respectively, although the findings from this study have since been questioned.…”

Section: Introductionmentioning

confidence: 99%

Identifying Promising Themes for Adolescent Vaping Warnings: A National Experiment

Rohde

Noar

Sheldon

et al. 2022

Nicotine &Amp; Tobacco Research

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Introduction Adolescent vaping remains a problem in the US, yet little is known about what health warning themes most discourage vaping among adolescents. We sought to identify the most compelling themes for vaping warnings for US adolescents. Methods Participants were a national probability sample of 623 US adolescents aged 13-17, recruited in summer 2020. Adolescents were randomized to one of five warning message themes about the potential health effects of vaping: 1) chemical harms, 2) lung harms, 3) COVID-19 harms, 4) nicotine addiction, or 5) control (messages about vape litter). The primary outcome was perceived message effectiveness (PME; 3-item scale). Secondary outcomes were negative affect (fear), attention, anticipated social interactions, and message novelty. Results Adolescents rated the chemical, lung, and COVID-19 harms warning messages higher on PME than nicotine addiction and control (all p<.05), while nicotine addiction was rated higher than control (p<.05). The chemical, lung, and COVID-19 harms warning themes also elicited greater negative affect than nicotine addiction and control (all p<.05). For all other secondary outcomes, the COVID-19 harms warning message theme was rated higher than nicotine addiction and control (all p<.05). Conclusion Adolescents perceived warning message themes about lung, chemical, and COVID-19 health effects of vaping as more effective than nicotine addiction. To discourage vaping, the FDA and others should communicate to youth about the health effects of vaping beyond nicotine addiction. Implications Adolescents perceived warning message themes about the lung, chemical, and COVID-19 health effects of vaping as more effective than nicotine addiction, while nicotine addiction was perceived as more effective than control themes about vaping litter. To discourage vaping among adolescents, health messaging should expand message themes to communicate about a broader set of health effects of vaping beyond nicotine addiction.

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Section: Introductionmentioning

confidence: 99%

Identifying Promising Themes for Adolescent Vaping Warnings: A National Experiment

Rohde

Noar

Sheldon

et al. 2022

Nicotine &Amp; Tobacco Research

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“…Considering e-cig vaping is a constant habit, other environmental hazards, such as viral infection, might occur during e-cig vaping. Dysregulated wound healing due to e-cig exposure could be one of the reasons for lung injury exacerbation, as observed in our prior report showing that e-cig vaping augments IAV infection-induced lung injury [13][14][15]. Lung broblasts play a critical role in tissue wound healing and repair, differentiating from broblast to myo broblast during the repair process, which will be accompanied by overexpression of ECM components, such as collagen, bronectin and α-smooth muscle actin (αSMA).…”

Section: Introductionmentioning

confidence: 75%

Tobacco and Menthol flavored electronic cigarettes induced inflammation and dysregulated repair in lung fibroblast and epithelium

Wang

Lucas

Pang

et al. 2023

Preprint

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Background Electronic cigarette (e-cig) vaping has increased in the past decade in the US, and e-cig use is misleadingly marketed as a safe cessation for quitting smoking. The main constituents in e-liquid are humectants, such as propylene glycol (PG) and vegetable glycerine (VG), but different flavoring chemicals are also used. However, the toxicology profile of flavored e-cigs in the pulmonary tract is lacking. We hypothesized that menthol and tobacco-flavored e-cig (nicotine-free) exposure results in inflammatory responses and dysregulated repair in lung fibroblast and epithelium. Method We exposed lung fibroblast (HFL-1) and epithelium (BEAS-2B) to Air, PG/VG, menthol flavored, or tobacco-flavored e-cig, and determined the cytotoxicity, inflammation, and wound healing ability of the cells in a microtissue chip model. Results After exposure, HFL-1 showed decreased cell number with increased IL-8 levels in the tobacco flavor group compared to air. BEAS-2B also showed increased IL-8 secretion after PG/VG and tobacco flavor exposure, while menthol flavor exposure showed no change. Both menthol and tobacco-flavored e-cig exposure showed decreased protein abundance of type 1 collagen (COL1A1), α-smooth-muscle actin (αSMA), and fibronectin as well as decreased gene expression level of αSMA (Acta2) in HFL-1. After tobacco flavor e-cig exposure, HFL-1 mediated wound healing and tissue contractility were inhibited. Furthermore, BEAS-2B exposed to menthol flavor showed significantly decreased gene expression of CDH1, OCLN, and TJP1. Conclusion Overall, tobacco-flavored e-cig exposure induces inflammation in both epithelium and fibroblasts, and tobacco-flavored e-cig inhibits wound healing ability in fibroblast.

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Vaping, Smoking Cessation, and Harm Reduction? Look Before You Leap

Pipe

2021

Canadian Journal of Cardiology

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Vaping and Respiratory Viruses: The End for ENDS?

Cited by 4 publications

References 15 publications

Identifying Promising Themes for Adolescent Vaping Warnings: A National Experiment

Identifying Promising Themes for Adolescent Vaping Warnings: A National Experiment

Tobacco and Menthol flavored electronic cigarettes induced inflammation and dysregulated repair in lung fibroblast and epithelium

Vaping, Smoking Cessation, and Harm Reduction? Look Before You Leap

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