Variability in Response to Transcranial Direct Current Stimulation of the Motor Cortex

Wiethoff, Sarah; Hamada, Masayuki; Rothwell, John C.

doi:10.1016/j.brs.2014.02.003

Cited by 704 publications

(698 citation statements)

References 41 publications

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“…In fact, the lack of changes in corticospinal excitability following tDCS with the cathode placed over M1 over M1 is in agreement with recent studies (Strube et al 2016, Wiethoff et al 2014. In this respect, the tDCS with the cathode placed over M1 protocol in the current study acted to amplify the effect of subsequent tDCS with the anode placed over M1 during skill training on performance improvement without overtly increasing corticospinal excitability, suggesting the priming nature of the particular protocol.…”

Section: Neurophysiological Effects Of Tdcs With the Cathode Placed Osupporting

confidence: 92%

“…Despite the abundance of research reporting tDCS effects on plasticity, in recent years large inter-individual variability in response to tDCS has been recognized (Datta et al 2012, Puri et al 2015, Wiethoff et al 2014. For example, Fujiyama et al observed that approximately 20% of participants (8 out of 39) did not show the expected corticospinal excitability increase following tDCS with anode placed over M1.…”

Section: Introductionmentioning

confidence: 99%

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Preconditioning tDCS facilitates subsequent tDCS effect on skill acquisition in older adults

Fujiyama

Hinder

Barzideh

et al. 2017

Neurobiology of Aging

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Functional motor declines that often occur with advancing age -including reduced efficacy to learn new skills -can have a substantial impact on the quality of life. Recent studies using non-invasive brain stimulation indicate that priming the corticospinal system by lowering the threshold for the induction of long-term potentiation (LTP)-like plasticity before skill training may facilitate subsequent skill learning. Here we utilized 'priming' protocol, in which we used transcranial direct current stimulation (tDCS) applying the cathode over the primary motor cortex (M1) prior to the anode placed over M1 during unimanual isometric force control training (FORCEtraining). Older individuals who received tDCS with the cathode placed over M1 prior to tDCS with the anode placed over M1 concurrent with FORCEtraining showed greater skill improvement and corticospinal excitability increases following the tDCS/FORCEtraining protocol compared to both young and older individuals who did not receive the preceding tDCS with the cathode placed over M1. The results suggested that priming tDCS protocols may be used in clinical settings to improve motor function and thus maintain the functional independence of older adults.

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Section: Neurophysiological Effects Of Tdcs With the Cathode Placed Osupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Preconditioning tDCS facilitates subsequent tDCS effect on skill acquisition in older adults

Fujiyama

Hinder

Barzideh

et al. 2017

Neurobiology of Aging

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“…Recent studies on healthy participants have emphasised that the response to tDCS is highly variable between individuals (López- Alonso et al, 2014;Wiethoff et al, 2014). Several clinical trials involving participants with stroke have also reported highly variable responses (Hummel et al, 2005;Bolognini et al, 2011;Hesse et al, 2011;Khedr et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…In healthy volunteers, the effects of tDCS on cortical excitability and performance are short-lasting and variable (Nitsche and Paulus, 2000;López-Alonso et al, 2014;Wiethoff et al, 2014). However, it is usually assumed that multiple daily applications in stroke may lead to a build-up of effects that are larger and more persistent.…”

Section: Introductionmentioning

confidence: 99%

Multiple sessions of transcranial direct current stimulation and upper extremity rehabilitation in stroke: A review and meta-analysis

Triccas

Burridge

Hughes

et al. 2016

Clinical Neurophysiology

112

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h i g h l i g h t stDCS and rehabilitation had small non-significant effect on upper extremity impairments. Varied tDCS and rehabilitation programmes were identified in selected studies. Future research needs to further analyse tDCS and therapy interventions in stroke. a b s t r a c tObjective: To systematically review the methodology in particular treatment options and outcomes and the effect of multiple sessions of transcranial direct current stimulation (tDCS) with rehabilitation programmes for upper extremity recovery post stroke. Methods: A search was conducted for randomised controlled trials involving tDCS and rehabilitation for the upper extremity in stroke. Quality of included studies was analysed using the Modified Downs and Black form. The extent of, and effect of variation in treatment parameters such as anodal, cathodal and bi-hemispheric tDCS on upper extremity outcome measures of impairment and activity were analysed using meta-analysis. Results: Nine studies (371 participants with acute, sub-acute and chronic stroke) were included. Different methodologies of tDCS and upper extremity intervention, outcome measures and timing of assessments were identified. Real tDCS combined with rehabilitation had a small non-significant effect of +0.11 (p = 0.44) and +0.24 (p = 0.11) on upper extremity impairments and activities at post-intervention respectively. Conclusion: Various tDCS methods have been used in stroke rehabilitation. The evidence so far is not statistically significant, but is suggestive of, at best, a small beneficial effect on upper extremity impairment. Significance: Future research should focus on which patients and rehabilitation programmes are likely to respond to different tDCS regimes.

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“…While the neuromodulatory after-effects induced by NIBS techniques (including tDCS) appear to be relatively stable over prolonged time courses (López-Alonso et al, 2015), the nature and magnitude of these effects varies considerably between individuals (Hamada, Murase, Hasan, Balaratnam, & Rothwell, 2013;Nettekoven et al, 2015;Nitsche & Paulus, 2001;Wiethoff, Hamada, & Rothwell, 2014). One source of this variability may be the brain statedependent nature of these effects, meaning that the history of endogenous activity of one region may be crucial to the effects of brain stimulation (Silvanto, Cattaneo, Battelli, & Pascual-Leone, 2008) and consequent activation of homeostatic and non-homeostatic metaplasticity mechanisms (Amadi et al, 2015;Muller-Dahlhaus & Ziemann, 2015).…”

Section: Caveats and Considerations For The Futurementioning

confidence: 99%

Effects of tDCS on motor learning and memory formation: A consensus and critical position paper

Buch

Santarnecchi

Antal

et al. 2017

Clinical Neurophysiology

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305

267

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Motor skills are required for activities of daily living. Transcranial direct current stimulation (tDCS) applied in association with motor skill learning has been investigated as a tool for enhancing training effects in health and disease. Here, we review the published literature investigating whether tDCS can facilitate the acquisition and retention of motor skills and adaptation. A majority of reports focused on the application of anodal tDCS over the primary motor cortex (M1) during motor skill acquisition, while some evaluated tDCS applied over the cerebellum during adaptation of existing motor skills. Work in multiple laboratories is under way to develop a mechanistic understanding of tDCS effects on different forms of learning, and to optimize stimulation protocols.Efforts are required to improve reproducibility and standardization. Overall, reproducibility remains to be fully tested, effect sizes with present techniques are moderate (up to d= 0.5) (Hashemirad, Zoghi, Fitzgerald, & Jaberzadeh, 2016) and the basis of inter-individual variability in tDCS effects is incompletely understood. It is recommended that future studies explicitly state in the Methods the exploratory (hypothesisgenerating) or hypothesis-driven (confirmatory) nature of the experimental designs. General research practices could be improved with prospective pre-registration of hypothesis-based investigations, more emphasis on detailed description of methods and use of post-publication open data repositories. A checklist is proposed for reporting tDCS investigations in a way that can improve efforts to assess reproducibility.

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Variability in Response to Transcranial Direct Current Stimulation of the Motor Cortex

Cited by 704 publications

References 41 publications

Preconditioning tDCS facilitates subsequent tDCS effect on skill acquisition in older adults

Preconditioning tDCS facilitates subsequent tDCS effect on skill acquisition in older adults

Multiple sessions of transcranial direct current stimulation and upper extremity rehabilitation in stroke: A review and meta-analysis

Effects of tDCS on motor learning and memory formation: A consensus and critical position paper

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