Variable clinical course of lichen planus following hepatitis C cure with direct-acting antivirals: A case series and literature review

Barajas, Lucero; Steuer, Meredith; Amerson, Erin

doi:10.1016/j.jaad.2020.05.159

Cited by 6 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Different case series on the effects of HCV-clearance by DAA on LP have been published. The data of these studies have shown that, after treatment with DAAs, 82% of cases show a resolution of or improvement in the disease, although some cases may relapse [128,129].…”

Section: Hcv and Licken Planus (Lp)mentioning

confidence: 99%

A Review on Extrahepatic Manifestations of Chronic Hepatitis C Virus Infection and the Impact of Direct-Acting Antiviral Therapy

Mazzaro

Quartuccio

Adinolfi

et al. 2021

Viruses

View full text Add to dashboard Cite

Extrahepatic manifestations are a feature of chronic hepatitis C virus (HCV) infection. In the course of chronic HCV infection, about 70% of patients have one or more extrahepatic manifestations. The latter are often the first and only clinical sign of infection. Experimental and clinical data support a causal association for many extrahepatic manifestations and HCV infection, which include mixed cryoglobulinemia, non-Hodgkin lymphomas (NHL), cardiovascular disease, insulin resistance, type 2 diabetes, neurological and psychiatric disease and other rheumatic diseases. All these extrahepatic conditions influence the morbidity, quality of life and mortality of HCV-infected patients. Currently, interferon-free therapeutic regimens with direct-acting antiviral agents (DAA) offer the possibility of treatment to almost the entire infected population, irrespective of stage of cirrhosis and associated serious comorbidities, always maintaining a high efficacy and tolerability. Several studies have shown a close association between HCV clearance by DAAs and an improvement or reduction in the risk of extrahepatic manifestations. Patients with HCV after a sustained virologic response (SVR) by DAA treatment have a lower risk than non-responders of developing cryoglobulinemic vasculitis and B-cell non-Hodgkin’s lymphomas. Furthermore, the SVR by DAA also reduces the risk of acute coronary syndrome, cardiovascular disease, insulin resistance and type 2 diabetes, and it improves atherosclerosis. HCV clearance by DAA also improves the quality of life and survival of patients with chronic HCV infection with associated extrahepatic diseases. Thus, DAAs should be initiated as early as possible in HCV patients with extrahepatic manifestations.

show abstract

Section: Hcv and Licken Planus (Lp)mentioning

confidence: 99%

A Review on Extrahepatic Manifestations of Chronic Hepatitis C Virus Infection and the Impact of Direct-Acting Antiviral Therapy

Mazzaro

Quartuccio

Adinolfi

et al. 2021

Viruses

View full text Add to dashboard Cite

show abstract

“…Furthermore, our findings seem to be consistent with the results of previous studies [ 36 , 37 ] that hypothesized a correlation between HCV and OLP. Conversely, a recent case series and literature review showed persistent or worsened lichen planus in almost 18% of HCV patients under treatment with DAAs, with a better prognosis in patients with only oral manifestations [ 38 ]. Further studies are needed to better characterize the effect of DAAs on lichen planus.…”

Section: Discussionmentioning

confidence: 99%

Effect of hepatitis C antiviral therapy on oral lichen planus and hyposalivation in inmates

Scelza¹

2021

aog

View full text Add to dashboard Cite

Background Oral lichen planus (OLP) and hyposalivation have been reported as extrahepatic manifestations of hepatitis C virus (HCV) infection. Our study evaluated the effect of direct antiviral agents (DAAs) on OLP and hyposalivation in convicts with chronic hepatitis C, examining patients before, during and after the antiviral treatment period with direct acting antiviral agents (DAAs). Methods We screened 198 inmates for the presence of the HCV antibody. Patients found to be positive underwent a quantitative HCV-RNA test and HCV genotype typing, as well as an oral cavity examination using a scoring system for OLP (REU score) and the clinical oral dryness score (CODS). Subsequently, all patients underwent DAA therapy and a systematic physical examination of the oral cavity at 1, 3 and 6 months from the beginning of treatment. Results Fifty patients (25.25%) had a positive HCV-RNA test. At baseline, OLP was detected in 4 patients (8%), with a mean REU score of 10.13±4, and different degrees of hyposalivation were seen in 17 patients (34%), with a mean CODS score of 4.71±1.72. Six months after the start of DAA therapy, we observed resolution of OLP in 3 patients (75%) and improvement in the remaining subject with a significantly lower mean REU score (2±4). Hyposalivation disappeared in 5 patients, improved in 10, and remained unchanged in 2 patients with a significantly lower mean CODS score (0.06±0.24). Conclusion This study demonstrated the effectiveness of DAAs in the treatment of OLP and hyposalivation.

show abstract

“…Seit längerer Zeit ist bekannt, dass eine Infektion mit dem Hepatitis-C-Virus ein signifikant erhöhtes Risiko für die Entwicklung eines Lichen planus darstellt [15]. Durch die seit 2014 verfügbaren Kombinationstherapien, bestehend lichkeit einer kompletten Abheilung nach antiviraler Therapie war beim oralen Lichen planus am höchsten [16]. In den von uns präsentierten Fällen konnte jedoch eine Hepatitis als Triggerfaktor des oralen Lichen planus ausgeschlossen werden.…”

Section: Mucosal Lichen Planus • Oral Lichen Ruber • Premalignant Conunclassified

Plattenepithelkarzinom auf dem Boden eines oralen Lichen planus

et al. 2020

View full text Add to dashboard Cite

ZusammenfassungBeim Lichen planus handelt es sich vermutlich um eine chronisch inflammatorische, immunologisch induzierte mukokutane Dermatose. Der Lichen planus mucosae manifestiert sich am häufigsten in der Mundhöhle. Diverse Triggerfaktoren wie bakterielle oder virale Infektionen, Medikamente oder physikalische Reize werden bei der Entstehung der Erkrankung diskutiert. Auch eine Assoziation mit Infektionen durch humane Papillomviren wurde beschrieben, ein kausaler Zusammenhang ist jedoch nicht hinreichend belegt. Als fakultative Präkanzerose kann sich auf dem Boden eines Lichen planus mucosae ein Plattenepithelkarzinom entwickeln, die maligne Transformationsrate ist aber gering. Das Risiko der malignen Transformation ist signifikant erhöht bei Patienten mit oralem Lichen planus, die rauchen, vermehrt Alkohol konsumieren oder an Hepatitis C erkrankt sind. Wir beschreiben 2 Patienten, bei denen sich lokal fortgeschrittene Plattenepithelkarzinome auf dem Boden eines langjährig bestehenden oralen Lichen planus entwickelten. Beide Fälle wurden erfolgreich durch radikale Tumorresektion mit anschließender Rekonstruktion und adjuvanter Radiatio/Radiochemotherapie behandelt.

show abstract

Variable clinical course of lichen planus following hepatitis C cure with direct-acting antivirals: A case series and literature review

Cited by 6 publications

References 4 publications

A Review on Extrahepatic Manifestations of Chronic Hepatitis C Virus Infection and the Impact of Direct-Acting Antiviral Therapy

A Review on Extrahepatic Manifestations of Chronic Hepatitis C Virus Infection and the Impact of Direct-Acting Antiviral Therapy

Effect of hepatitis C antiviral therapy on oral lichen planus and hyposalivation in inmates

Plattenepithelkarzinom auf dem Boden eines oralen Lichen planus

Contact Info

Product

Resources

About