Variable response to inhaled salbutamol of different lung function parameters in healthy children

Riedel, Frank; Hart, Harald

doi:10.1007/bf02713658

Cited by 9 publications

(5 citation statements)

References 27 publications

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“…FEV 1 is considered to be the most relevant lung function parameter for demonstrating a bronchodilating response [1,7]. In the present study, a mean increase of 4% in FEV 1 after inhalation of salbutamol was observed, which is comparable to results of similar studies [3,4,8]. In asthmatic subjects, an increase of 12% or more in FEV 1 after bronchodilation is considered to be a signi®cant clinical bronchodilating respons [1,12].…”

Section: Discussionsupporting

confidence: 92%

“…In the present study, an increase of 12.4% in FEV 1 was noticed in only one child. The increase in MEF 50 after inhalation of salbutamol was similar to that found in similar studies, but the increase in MEF 25 after bronchodilation was slightly higher in the present study [3,4,8]. The fact that in the present study, a bronchodilation could be detected, suggests the eectiveness of beta-agonists in healthy children.…”

Section: Discussionsupporting

confidence: 89%

“…healthy) children. However, only limited information is available on the eect of beta-agonists in healthy children [1,3,4,8]. The aim of the present study was to evaluate the eect of 200 lg salbutamol, using a placebo-controlled single blind study design, on lung function parameters of healthy children aged 7±14 years.…”

Section: Introductionmentioning

confidence: 98%

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Effect of salbutamol on lung function parameters of healthy children

2001

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

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Effect of salbutamol on lung function parameters of healthy children

2001

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“…This result is in favour of spirometry changes due to bronchomotor tone exceeding that of mere biological and instrumental variability. The bronchomotor tone is nearly always present in healthy children [35], therefore in our study having only assessed BDR in healthy children, we have measured the maximal changes that could occur even though we are not able to separate the different components of this change.…”

Section: Discussionmentioning

confidence: 99%

Forced expiratory flows’ contribution to lung function interpretation in schoolchildren

et al. 2014

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Forced expiratory flow (FEF) at low lung volumes are supposed to be better at detecting lung-function impairment in asthmatic children than a forced volume. The aim of this study was to examine whether FEF results could modify the interpretation of baseline and post-bronchodilator spirometry in asthmatic schoolchildren in whom forced expiratory volumes are within the normal range.Spirometry, with post-bronchodilator vital capacity within 10% of that of baseline in healthy and asthmatic children, was recorded prospectively. We defined abnormal baseline values expressed as z-scores <-1.645, forced expiratory volume in 1 s (FEV1) reversibility as a baseline increase >12%, FEF reversibility as an increase larger than the 2.5th percentile of post-bronchodilator changes in healthy children.Among 66 healthy and 50 asthmatic schoolchildren, only two (1.7%) children with normal vital capacity and no airways obstruction had abnormal baseline forced expiratory flow at 25-75% of forced vital capacity (FEF25-75%). After bronchodilation, among the 45 asthmatic children without FEV1 reversibility, 5 (11.1%) had an FEF25-75% increase that exceeded the reference interval.Isolated abnormal baseline values or significant post-bronchodilator changes in FEF are rare situations in asthmatic schoolchildren with good spirometry quality. @ERSpublications Forced expiratory flows don't add useful information over forced expiratory volumes and their ratio in schoolchildren

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“…The gestational age of the neonates was determined on the day of birth using the Farr-criteria Π-Pulmonary function tests were performed at least four weeks after delivery and included vital capacity, functional residual capacity, residual volume, airway resistance and thoracic gas volume (bodyplethysmography) and forced expiratory flow measurements as described elsewhere [12].…”

Section: Methodsmentioning

confidence: 99%

Prematurity and maternal bronchial hyperresponsiveness

Riedel

Achenbach²,

Rieger³

1989

Jpme

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Bronchial reactivity was compared among mothers of neonates with unexplained premature delivery and mothers of preterm neonates with known etiology of prematurity as well as mothers who delivered their children at term. Bronchial reactivity was measured by unspecific bronchial provocation testing with histamine. A significantly higher incidence of bronchial hyperreactivity was found among mothers with unexplained prematurity as compared to the control groups. An imbalance in the autonomic nerve system leading to prematurity as well as bronchial hyperresponsiveness is suggested.

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Variable response to inhaled salbutamol of different lung function parameters in healthy children

Cited by 9 publications

References 27 publications

Effect of salbutamol on lung function parameters of healthy children

Effect of salbutamol on lung function parameters of healthy children

Forced expiratory flows’ contribution to lung function interpretation in schoolchildren

Prematurity and maternal bronchial hyperresponsiveness

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