2021
DOI: 10.3389/fneur.2021.615017
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Variable Temporal Cerebral Blood Flow Response to Acetazolamide in Moyamoya Patients Measured Using Arterial Spin Labeling

Abstract: Cerebrovascular reserve capacity (CVR), an important predictor of ischaemic events and a prognostic factor for patients with moyamoya disease (MMD), can be assessed by measuring cerebral blood flow (CBF) before and after administration of acetazolamide (ACZ). Often, a single CBF measurement is performed between 5 and 20 min after ACZ injection. Assessment of the temporal response of the vasodilation secondary to ACZ administration using several repeated CBF measurements has not been studied extensively. Furthe… Show more

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Cited by 5 publications
(12 citation statements)
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“…Parametric maps of time-to-peak (TTP) were generated. In addition, a structural 3D T2-weighted fluid attenuated inversion recovery (FLAIR) image, 3D contrast-enhanced T1-weighted (CE-T1WI) image and 3D time-of-flight MR angiography were acquired [ 9 , 10 ].…”
Section: Methodsmentioning
confidence: 99%
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“…Parametric maps of time-to-peak (TTP) were generated. In addition, a structural 3D T2-weighted fluid attenuated inversion recovery (FLAIR) image, 3D contrast-enhanced T1-weighted (CE-T1WI) image and 3D time-of-flight MR angiography were acquired [ 9 , 10 ].…”
Section: Methodsmentioning
confidence: 99%
“…CBF and TTP maps together with FLAIR images were registered to each patient’s CE-T1WI image. Left and right middle cerebral artery (MCA) territories were delineated by applying the inverse transformation from the vascular MNI template space by spatial normalization of a CE-T1WI image for each patient [ 9 , 10 , 30 ]. Cerebrovascular reserve capacity (CVR) was calculated as CBF after ACZ injection relative to CBF at examination baseline (see below).…”
Section: Methodsmentioning
confidence: 99%
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“…Magnetic resonance imaging (MRI) and computed tomography (CT) protocols include regular CBF measurements but usually also include assessments of the CVR by repeated CBF assessments after the administration of the cerebral vasodilator acetazolamide (ACZ). In particular, arterial spin labeling (ASL), a non-invasive and repeatable MRI-based method, to estimate CBF has shown promise and potential use in conjunction with the ACZ challenge ( 6 , 7 ). In addition, positron emission tomography (PET) imaging (with 15 O-gas) may provide further information such as OEF and CMRO 2 ( 8 , 9 ).…”
Section: Introductionmentioning
confidence: 99%