Objective. To explore the effects of cluster nursing on VAS score and urinary system function of patients after percutaneous nephrolithotomy with pneumatic lithotripsy (PCNL). Methods. November 2019-January 2019, 114 patients with PCNL who received treatment in our hospital were selected and randomly divided into two groups: the control group and the study group. The study group received cluster nursing, and the control group received routine nursing. Compare the Barthel index (BI), between two groups, SAS score, complications rate, surgical outcomes, pain scores, quality of life scores, knowledge awareness rate, and satisfaction rate were compared. Results. There were no significant variations in Bi and SAS scores before the nursing (
P
>
0.05
). The BI ratings were clearly higher after nursing, whereas the SAS and pain levels were considerably lower, however, the research group altered more dramatically (
P
0.05
). The study group’s incidence of complications was lower (
P
0.05
) than the control group’s; the study group’s hospitalization cost was lower, and the hospitalization and lower bed activity were shorter (
P
0.05
); after the nursing, the organised quality score was significantly higher in both groups, but the research group changed more dramatically (
P
0.05
). Compared with the control group, the knowledge of the research team was higher (
P
<
0.05
); after the nursing, both group satisfaction scores were obviously high, but the study group changes more significantly (
P
<
0.05
). Conclusion. After PCNL treatment, the patient receives cluster therapy, improving the patient’s anxiety, reducing the degree of pain, and improving the quality of life in patients, and the patient satisfaction is high. Therefore, cluster nursing is worthy of extensive application in the postoperative care of patients with PCNL.