Variables Influencing Drug Release from Layered Matrix System Comprising Hydroxypropyl Methylcellulose

Phaechamud, Thawatchai

doi:10.1208/s12249-008-9085-1

Cited by 22 publications

(13 citation statements)

References 17 publications

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“…It was also observed that F3 with the maximum hardness showed good drug retardation effects, indicating that hardness can also influence the release of the drug up to some extent. 25,26 Friability was also well below the rejection range, that is 1% according to pharmacopoeia and the maximum friability that was calculated was found in F9 were 0.14 ± 0.04. Weight variations were ranged from 349.5 to 351.35 and were within the acceptance region.…”

Section: Discussionmentioning

confidence: 75%

Fabrication and Analysis of Hydroxypropylmethyl Cellulose and Pectin‐Based Controlled Release Matrix Tablets Loaded with Loxoprofen Sodium

Zaman¹,

Rasool²,

Ali³

et al. 2014

Adv Polym Technol

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ABSTRACT:The basic purpose of the current study was to formulate controlled release matrix tablets loaded with loxoprofen sodium using pectin and hydroxypropylmethyl cellulose (HPMC). The effect of these polymers on the release pattern of drug from the formulated matrix system was evaluated. Different concentrations of these polymers alone as well as polymeric blends were used in tablets formulation using wet granulation technique. The differential scanning calorimetric technique was used to detect the chemical interactions between ingredients. Precompression studies were done to assess fineness and flow properties of the granules. Hardness, friability, weight variations, and percentage drug contents were calculated for the evaluation of compressed tablets. F9 formulated in the combination of HPMC and pectin in the ratio of 30:10 showed better retardation during dissolution studies. Upon application of statistical models, the diffusion process was found to be dominant for drug release following the Higuchi model. HPMC and pectin were found suitable for the formulation of controlled release matrix tablets. C 2014 Wiley Periodicals, Inc. Adv Polym Technol 2015, 34, 21493; View this article online at wileyonlinelibrary.com.

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Section: Discussionmentioning

confidence: 75%

Fabrication and Analysis of Hydroxypropylmethyl Cellulose and Pectin‐Based Controlled Release Matrix Tablets Loaded with Loxoprofen Sodium

Zaman¹,

Rasool²,

Ali³

et al. 2014

Adv Polym Technol

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“…However, a further increase of HPMC ratio resulted in a slight retardation of drug release. This slow release was due to the formation of a thick gel structure that delayed drug release from the tablet matrix, where hydration of the HPMC particles resulted in extensive swelling (19). A thick gel layer result in a considerable increase in the diffusion pathway for the drug molecules, and consequently, the drug release rate was reduced.…”

Section: Drug-excipients Compatibility Studiesmentioning

confidence: 99%

Optimization and In vivo Pharmacokinetic Study of a Novel Controlled Release Venlafaxine Hydrochloride Three-Layer Tablet

Aboelwafa

Basalious

2010

AAPS PharmSciTech

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Abstract. Several matrix tablet formulations (hydrophilic-based, wax-based, and three-layer tablets) were designed for controlling the release of the highly water soluble drug, venlafaxine hydrochloride (VenHCl) for once-daily administration. The three-layer tablets consist of non-swellable, compritol-based middle layers containing the drug to which hydrophilic top and bottom barrier layers were applied. A 2 3 full-factorial design was employed for optimization and to explore the effect of different variables on the release rate of the drug from the three-layer tablets. The optimized levels of each independent variable were based on the criterion of desirability. The calculated values of f 1 and f 2 were 4.131 and 79.356, respectively; indicating that the release profile of the optimized PEO layered tablet formulation is comparable to that of the target release model. The pharmacokinetic parameters of VenHCl from the optimized three-layer tablet was compared to the marketed extended release capsule as a reference in healthy human subjects using a randomized crossover design. In this study, the 90% confidence interval for AUC 0-24 and AUC 0−∞ are within (0.8-1.25), which satisfied the bioequivalence criteria. It could be concluded that a promising once-daily extended-release three-layer tablet of the highly water soluble drug, VenHCl, was successfully designed.

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“…The larger inner tablet indicating a thinner outer layer produced a higher hardness; therefore, the inner tablet played the more important role relating to tablet hardness. Actually, a thicker outer layer should produce higher hardness as previously reported (23). They investigated the physical properties of compressed three-layered tablets where the increasing amount of barrier layer produced higher tablet hardness.…”

Section: Discussionmentioning

confidence: 80%

Double-Layered Matrix of Shellac Wax-Lutrol in Controlled Dual Drug Release

Phaechamud

Choncheewa

2015

AAPS PharmSciTech

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Abstract. Double-layered matrix tablets prepared from shellac wax-lutrol were fabricated using a molding technique, and the release of hydrochlorothiazide and propranolol HCl from the inner tablet or outer layer was studied. The simultaneous determination of dual drug release was measured with first derivative UV spectrophotometry. The tablet containing shellac wax as the outer tablet and lutrol as the inner tablet showed more appropriate drug release and the size of the inner layer influenced the rate of drug release. In addition, the aqueous solubility of the drug and the components of the inner tablet or outer layer affected the drug release behavior. Most of the double-layered tablets exhibited the drug-release pattern which fitted well with zero-order kinetic due to the restriction of the release surface. Biphasic drug release pattern was found in the tablet of which the outer layer rapidly eroded. The drug dissolution data from drug-loaded-outer layer could predict the dissolution time for the outer layer of drug-loaded inner part of double-layered matrix tablet. Incorporation of lutrol increased the drug release from shellac wax matrix, and the zero-order release was attained by fabricating it into a double-layered tablet.

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Variables Influencing Drug Release from Layered Matrix System Comprising Hydroxypropyl Methylcellulose

Cited by 22 publications

References 17 publications

Fabrication and Analysis of Hydroxypropylmethyl Cellulose and Pectin‐Based Controlled Release Matrix Tablets Loaded with Loxoprofen Sodium

Fabrication and Analysis of Hydroxypropylmethyl Cellulose and Pectin‐Based Controlled Release Matrix Tablets Loaded with Loxoprofen Sodium

Optimization and In vivo Pharmacokinetic Study of a Novel Controlled Release Venlafaxine Hydrochloride Three-Layer Tablet

Double-Layered Matrix of Shellac Wax-Lutrol in Controlled Dual Drug Release

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