Variant Hemoglobin Spectrum By Cation Exchange High Performance Liquid Chromatography: A Study 0f 2035 Subjects

Sarvaiya, Ankur N; Chauhan, Sanjaykumar C.

doi:10.21276/apalm.1393

Cited by 3 publications

(9 citation statements)

References 17 publications

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“…In our study the prevalence for sickle cell trait was found out to be 4.7%, which is very much comparable with the study done by Sarvaiya et al 13 which showed a prevalence of 4.71%. But other studies showed a relatively less prevalence like Buch et al 3 who had done a study on 3465 patients in Pune and quoted a prevalence of 0.2%.…”

Section: Sickle Cell Traitsupporting

confidence: 91%

“…In the present study prevalence for Sickle-thalassemia was found out to be 0.94% which is comparable to the study done by Shrivastav et al 15 , Baruah et al 14 and Sarvaiya et al 13 quoting a prevalence of 0.72%, 0.59% and 0.68% respectively. We did not find any case of other abnormal hemoglobins such as HbE, HbD, HbC, HbQ and other double heterozygous in our study.…”

Section: Double Heterozygous For Sickle-thalassemiasupporting

confidence: 89%

“…Mondal et al 12 had done a study on 119336 patients in Kolkata and quoted a prevalence of 1.66% for Beta thalassemia major which is comparable to our study. Iqbal et al and Sarvaiya et al 13 quoated a prevalence of 0.02% and 0.83% for Beta thalassemia major.…”

Section: Beta Thalassemia Majormentioning

confidence: 99%

“…Buch et al 3 quoted a prevalence of 0.2%, Sarvaiya et al 13 15 quoted a 1.17% prevalence for sickle cell disease.…”

Section: Sickle Cell Diseasementioning

confidence: 99%

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Spectrum of Hemoglobinopathies Diagnosed by High Performance Liquid Chromatography at a Tertiary Care Centre: An Observational Study

Bajaj¹,

Gupta²

2021

mvpjms

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Introduction: Thalassemia and other hemoglobinopathies are the most common routinely encountered congenital anemias in India. Sickle cell anemia is very common, so a study to rule out all the hemoglobinopathies is essential. Aims and Objectives: The present study was conducted to diagnose various hemoglobinopathies among clinically suspected cases., the present study was conducted to diagnose various hemoglobinopathies among clinically suspected cases. Materials and Methods: A total of 212 cases cases were undertaken in this study after they met the inclusion and exclusion criteria. HPLC was performed on the samples received in the Central Clinical Laboratory of Dr. Vasantrao Pawar Medical College, Hospital and Research Centre, Nashik, Maharashtra. Results: Out of 212 cases, 42 cases showed positivity for thalassemia or presence of abnormal hemoglobin, with 8% cases of Beta thalassemia trait, 1.88% cases of Beta thalassemia major, 4.7% cases of Sickle cell trait, 4.24% cases of Sickle cell disease and 0.94% cases of Sickle-thalassemia. Conclusions: HPLC is a fast, reliable, and cost-effective method to diagnose any suspected case of hemoglobinopathy.

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Section: Sickle Cell Traitsupporting

confidence: 91%

Section: Double Heterozygous For Sickle-thalassemiasupporting

confidence: 89%

Section: Beta Thalassemia Majormentioning

confidence: 99%

“…Buch et al 3 quoted a prevalence of 0.2%, Sarvaiya et al 13 15 quoted a 1.17% prevalence for sickle cell disease.…”

Section: Sickle Cell Diseasementioning

confidence: 99%

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Spectrum of Hemoglobinopathies Diagnosed by High Performance Liquid Chromatography at a Tertiary Care Centre: An Observational Study

Bajaj¹,

Gupta²

2021

mvpjms

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“…The third most commonest hemoglobinopathy that was detected in the total population of 29,293 patients within the 14 studies was of Hb E. Hb E constituted about 18.9% of hemoglobinopathies. Except for the reports of Sachdev et al [ 1 ], Shrivastav et al [ 3 ], Bhalodia et al [ 6 ], Sarvaiya and Chauhan [ 10 ], Shankar et al [ 12 ], and Jain and Saxena [ 13 ], Hb E remained the third most common hemoglobin variant detected.…”

Section: Reviewmentioning

confidence: 99%

Hemoglobin Variants in Patients With Microcytic Hypochromic Anemia: A Review of Indian Studies

Kharche¹,

Bhake²

2023

Cureus

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Microcytic hypochromic (MCHC) anemia with hemolytic components is common in clinical practice. Hemoglobinopathies and variants are one of the important underlying causes of MCHC anemia. The Indian population, by large, as various studies reported, showed a plethora of hemoglobinopathies with regional predilections for its types. The present systematic review is carried out for the evaluation of MCHC anemia for its underlying causes of hemoglobinopathies and their loco regional comparisons. The review was carried out by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method with selected keywords through the Google advanced search matchable to the objectives of the present systematic review. Upon the systematic review, it was observed that β thalassemia trait (βTT) remained the highest reported hemoglobinopathy. The other abnormal hemoglobin variants, though rare, also have been reported in the reviewed articles. It is concluded that patients with MCHC refractory to its regular treatment should be subjected to high-performance liquid chromatography (HPLC) in exclusion of underlying hemoglobinopathy and abnormal hemoglobin variants.

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Family Study of Different Hemoglobin Disorders and Variants in North-Western India in Tertiary Center

Garg,

Jain,

Singh

et al. 2024

Indonesian J. Clin. Pathol. Med. Lab.

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Hemoglobin-related disorders are among the most common inherited genetic disorders in the world. They are posing a serious health burden to the global health system. As per WHO, the highest incidence of hemoglobinopathies is in the Middle East and Indian subcontinent. Screening methods like High-Performance Liquid Chromatography (HPLC) help in determining values of HbA, HbA2, and HbF and diagnosing hemoglobinopathies at the initial stages. The present study aims to determine the role of family studies using HPLC in hemoglobin-related disorders. A retrospective study of 48 months between January 2019 and January 2024, comprising 137 patients was conducted. Patients attending the Outpatient Department (OPD)and admitted to the Inpatient Department (IPD) with anemia and abnormal values of different hemoglobin (HbA, HbA2, HbF, etc.) along with family members were included in this study. Patients with less than 3 months of history of blood transfusion and less than 6 months of age were excluded from the study. A total number of 572 patients with Hb < 11 g/dL were screened. Out of 153 (26.74%) patients, 137 (23.95%) patients and their family members agreed to the family study. Among 137 patients, 72 were females and 65 were males. Therefore M:F ratio was 0.90:1. Pallor was present in 121 (88.32%) cases and splenomegaly was seen in 49 cases (35.76%). HPLC along with family studies is a quick and minimally invasive method to screen high to medium-risk large communities, which in return helps in controlling the spread of clinically dreadful homozygous state of hemoglobin disorders.

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Variant Hemoglobin Spectrum By Cation Exchange High Performance Liquid Chromatography: A Study 0f 2035 Subjects

Cited by 3 publications

References 17 publications

Spectrum of Hemoglobinopathies Diagnosed by High Performance Liquid Chromatography at a Tertiary Care Centre: An Observational Study

Spectrum of Hemoglobinopathies Diagnosed by High Performance Liquid Chromatography at a Tertiary Care Centre: An Observational Study

Hemoglobin Variants in Patients With Microcytic Hypochromic Anemia: A Review of Indian Studies

Family Study of Different Hemoglobin Disorders and Variants in North-Western India in Tertiary Center

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