Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horses

Matteis, Rafael de; Pereira, Guilherme Luís; Casarotto, Letícia T.; Tavernaro, Anna Júlia S.; Silva, Josineudson Augusto Ii Vasconcelos; Chardulo, Luis Artur Loyola; Curi, Rogério Abdallah

doi:10.1016/j.jevs.2018.09.007

Cited by 2 publications

(1 citation statement)

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“…That last result is not easily comparable with our study because of the almost total absence of CC homozygotes in the sampled Anglo-Arabian population and the substantial differences in classes of race distance between the two studies. The MSTN gene has a significant impact on biometric traits [ 47 , 48 ] and muscle fibre [ 49 ], and the related and pooled effects of MSTN genotype, the breed and race distance are well described by Rooney et al [ 50 ] Those last authors consider that TT horses at SNP rs397152648 have a greater body mass and the SINE insertion influences muscle fibre composition and types, with different genotypes, which are consequently best suited for sprint or stamina sport activities. Indeed, the performance in relation to the distance of races has been later confirmed by Dall’Olio et al [ 51 ] and Petersen et al [ 52 ] who have demonstrated the functional role of MSTN gene in horse breeds used for sprint races, like the Quarter Horse.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms at Myostatin Gene (MSTN) and the Associations with Sport Performances in Anglo-Arabian Racehorses

Pira¹,

Vacca

Dettori

et al. 2021

Animals

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One hundred and eighty Anglo-Arabian horses running 1239 races were sampled for the present study. DNA was extracted from the blood and myostatin gene, MSTN, was genotyped. Moreover, prizes won and places were achieved for the 1239 races to perform association analyses between the different genotypes and sport traits. Two SNPs already reported in previous studies regarding the Thoroughbred breed, rs69472472 and rs397152648, were revealed as polymorphic. The linkage disequilibrium analysis investigating the haplotype structure of MSTN did not evidence any association block. Polymorphism at SNP rs397152648, previously known as g.66493737 T>C, significantly influenced sport traits, with heterozygous horses TC showing better results than homozygotes TT. The portion of variance due to the random effect of the individual animal, and the other phenotypic effects of sex, percentage of Arabian blood and race distance, computed together with the genotype at MSTN in the statistical models, exerted a significant influence. Hence, this information is useful to improve knowledge of the genetic profile of Anglo-Arabian horses and a possible selection for better sport performance.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms at Myostatin Gene (MSTN) and the Associations with Sport Performances in Anglo-Arabian Racehorses

Pira¹,

Vacca

Dettori

et al. 2021

Animals

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Unveiling Genetic Potential for Equine Meat Production: A Bioinformatics Approach

Šimon,

Kaić,

Potočnik

2024

Animals

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In view of the predicted significant increase in global meat production, alternative sources such as horsemeat are becoming increasingly important due to their lower environmental impact and high nutritional value. This study aimed to identify SNP markers on the GeneSeek® Genomic Profiler™ Equine (Neogen, Lansing, MI, USA) that are important for horsemeat production traits. First, orthologous genes related to meat yield in cattle and common genes between horses and cattle within QTLs for body size and weight were identified. Markers for these genes were then evaluated based on predicted variant consequences, GERP scores, and positions within constrained elements and orthologous regulatory regions in pigs. A total of 268 markers in 57 genes related to meat production were analyzed. This resulted in 27 prioritized SNP markers in 22 genes, including notable markers in LCORL, LASP1, IGF1R, and MSTN. These results will benefit smallholder farmers by providing genetic insights for selective breeding that could improve meat yield. This study also supports future large-scale genetic analyses such as GWAS and Genomic Best Linear Unbiased Prediction (GBLUP). The results of this study may be helpful in improving the accuracy of genomic breeding values. However, limitations include reliance on bioinformatics without experimental validation. Future research can validate these markers and consider a wider range of traits to ensure accuracy in equine breeding.

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Variants in the Chromosomal Region of the Myostatin Gene and Their Association With Lines, Performance, and Body Measurements of Quarter Horses

Cited by 2 publications

References 33 publications

Polymorphisms at Myostatin Gene (MSTN) and the Associations with Sport Performances in Anglo-Arabian Racehorses

Polymorphisms at Myostatin Gene (MSTN) and the Associations with Sport Performances in Anglo-Arabian Racehorses

Unveiling Genetic Potential for Equine Meat Production: A Bioinformatics Approach

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