Variants on ESR1 and their Association with Prostate Cancer Risk: A Meta-analysis

Ding, Xiang; Cui, Fengmei; Xu, Songtao; Pu, Jinxian; Huang, Yuhua; Zhang, Jianglei; Wei, Xuedong; Hou, Jianquan; Chang, Yan

doi:10.7314/apjcp.2012.13.8.3931

Cited by 4 publications

(1 citation statement)

References 32 publications

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“…Remarkably, both sites of rs9340799 and rs2234693 have been widely studied in ESRα genetic polymorphisms [ 9 – 12 ], but ESRα rs9340799 or rs2234693 were independent of PC susceptibility because of quality and quantity limitations. The meta-analysis of ESRα rs9340799 and rs2234693 was firstly conducted by Ding [ 10 ] in 2012, indicating that rs9340799, not rs2234693, confered an elevated risk of PC. Gu's study [ 11 ] demonstrated that there was no significant difference between 4,884 case groups and 10,134 control groups in rs2234693 regardless of allele or other models (allele model, OR = 0.98; 95 % CI, 0.88–1.08; P = 0.685; dominant model, OR = 0.98; 95 % CI, 0.89–1.07; P = 0.685; recessive model, OR = 0.96; 95 % CI, 0.81–1.14; P = 0.657; homozygous model, OR = 0.96; 95 % CI, 0.77–1.19; P = 0.708; heterozygous model, OR = 0.96; 95 % CI, 0.81–1.13; P = 0.708, respectively).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive assessment of the association between estrogen receptor of alpha polymorphisms and the risk of prostate cancer: evidence from a meta-analysis

Yang

et al. 2017

Oncotarget

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We performed a meta analysis to access the relationship of estrogen receptor of alpha (ESRα) polymorphisms with the risk of prostate cancer (PC). Twenty-four case-control studies (including 5477 cases and 10708 controls) were recruited for meta-analysis. The strongest association with the risk of PC was observed between ESRα rs9340799 and rs2234693 under the two genotypic models of allele and codominance in the overall population (p < 0.05). Under the subgroup analysis of ethnicity, we observed that ESRα rs9340799 was significantly associated with the susceptibility to PC in European population (AvsG, p = 0.000; AAvsGG, p = 0.002), while there was no difference in Asian (AvsG, p = 0.493; AAvsGG, p = 0.736) or African population (AvsG, p = 0.800; AAvsGG, p = 0.788). The results also showed that significant association between rs2234693 and the susceptibility to PC in European (CvsT, p = 0.004; CCvsTT, p = 0.001) and Asian population (CvsT, p = 0.004; CCvsTT, p = 0.003), but not in African population (CvsT, p = 0.636; CCvsTT, p = 0.669). The meta-analysis indicated that ESRα rs9340799 and rs2234693 might contribute to susceptibility and development of PC in European population.

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Section: Introductionmentioning

confidence: 99%

Comprehensive assessment of the association between estrogen receptor of alpha polymorphisms and the risk of prostate cancer: evidence from a meta-analysis

Yang

et al. 2017

Oncotarget

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The association between the APE1 Asp148Glu polymorphism and prostate cancer susceptibility: a meta-analysis based on case–control studies

Zhou

Jiao

et al. 2014

Mol Genet Genomics

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The apurinic/apyrimidinic endonuclease 1 (APE1) plays important roles in the repair of DNA damage and adducts. However, previous case-control studies on the association between the APE1 Asp148Glu polymorphism and prostate cancer susceptibility have shown contradictory results, this meta-analysis was performed to draw a more precise estimation of the relationship. A total of seven case-control studies including 1,294 cases and 1,762 controls were included for analysis. In overall, no significant associations were found in all genetic models (GG vs. TT: OR = 1.16, 95 % CI 0.89-1.52; TG vs. TT: OR = 1.04, 95 % CI 0.81-1.35; the dominant model GG + TG vs. TT: OR = 1.12, 95 % CI 0.96-1.30; the recessive model GG vs. TG + TT: OR = 0.90, 95 % CI 0.77-1.04); in the subgroup by source of control, we found a significant association for the dominant model in Hospital-based subgroup (OR = 1.34, 95 % CI 1.08-1.68), no significant associations were found in other models in the subgroups. This meta-analysis suggested that the APE1 Asp148Glu polymorphism was a risk factor for prostate cancer susceptibility in Hospital-based population.

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Estrogen receptor alpha gene polymorphisms and risk of prostate cancer: a meta-analysis involving 18 studies

Gu¹,

Wang²,

Chen

2014

Tumor Biol.

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Genetic and epigenetic changes in the estrogen receptor alpha (ER-α) gene, according to multiple lines of evidence, might alter its expression and its downstream signaling thereby increasing the risk of developing prostate cancer. The purpose of this meta-analysis was to determine whether polymorphisms in two intronic restriction sites in the ER-α (PvuII and XbaI) gene contribute to prostate cancer. A literature search for eligible studies published before November 5, 2013 was conducted in the PubMed, Embase, China Biology Medicine (CBM), and CNKI databases. Pooled crude odds ratios (ORs) and their corresponding 95 % confidence intervals (CIs) were calculated. Eighteen case-control and cohort studies were included in this meta-analysis with a total 4,884 prostate cancer cases and 10,134 healthy controls. Two common ER-α polymorphisms were examined: IVS1-397 C>T (a.k.a. the PvuII restriction site, rs2234693) and IVS1-351 A>G (a.k.a. the XbaI restriction site, rs9340799). Results from this meta-analysis showed that the PvuII polymorphism was not significantly associated with prostate cancer risk in any of the racial subgroups, either by allelic or genotypic frequencies. However, this meta-analysis revealed that the G allele in the XbaI polymorphism was associated with a statistically significant increase in the risk of prostate cancer. In a stratified analysis based on ethnicity, the XbaI G allele remained significantly correlated with an increased risk of prostate cancer in Africans; this correlation, however, was not found in Caucasians or Asians. In summary, a positive association correlation was observed between frequencies of the XbaI (A>G) polymorphism and prostate cancer, especially in Africans, but not such correlation was found with regard to the frequency of the PvuII (C>T) polymorphism.

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Variants on ESR1 and their Association with Prostate Cancer Risk: A Meta-analysis

Cited by 4 publications

References 32 publications

Comprehensive assessment of the association between estrogen receptor of alpha polymorphisms and the risk of prostate cancer: evidence from a meta-analysis

Comprehensive assessment of the association between estrogen receptor of alpha polymorphisms and the risk of prostate cancer: evidence from a meta-analysis

The association between the APE1 Asp148Glu polymorphism and prostate cancer susceptibility: a meta-analysis based on case–control studies

Estrogen receptor alpha gene polymorphisms and risk of prostate cancer: a meta-analysis involving 18 studies

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