Variation in bioactive compounds, antioxidant and antibacterial activity of Iranian Chrysanthemum morifolium cultivars and determination of major polyphenolic compounds based on HPLC analysis

Hodaei, Mahboobeh; Rahimmalek, Mehdi; Arzani, Ahmad

doi:10.1007/s13197-020-04666-1

Cited by 25 publications

(16 citation statements)

References 29 publications

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“…Similarly, rutin has been reported to help protect against several types of cancer through various mechanisms by regulating multiple cellular signaling pathways 3 . Rutin and luteolin were the most abundant flavonoid compounds in C. morifolium cultivars used in the present research 6 . Among the six bioactive compounds classified as major constituents of Iranian C. morifolium cultivars, only three (luteolin, quercetin, and apigenin) were presented as compounds of Chinese Chrysanthemum in the Traditional Chinese Medicine System Pharmacology database (TCMSP).…”

Section: Discussionmentioning

confidence: 72%

“…Of the eight chemical compounds of Chrysanthemum obtained from our previously report 6 (Fig. 3 ), six major bioactive compounds namely luteolin, quercetin, rutin, chlorogenic acid, ferulic acid, and apigenin were selected as potential active ingredients of Chrysanthemum cultivars.…”

Section: Resultsmentioning

confidence: 99%

“…The major components of studied Chrysanthemum cultivars, including luteolin, quercetin, rutin, chlorogenic acid, ferulic acid, and apigenin were retrieved from our previous report 6 . In that report, we identified the flavonoid compounds of these cultivars using High-Performance Liquid Chromatography analysis.…”

Section: Methodsmentioning

confidence: 99%

“…Chrysanthemum ( Chrysanthemum morifolium Ramat.) is an important medicinal herb that has been used for centuries in many Asian countries due to its extensive biological characteristics, including its antioxidant, anticancer, antimutagenic, anti-inflammatory, and antibacterial properties 6 . Flavonoids, a major class of phenolic compounds, exhibit high antioxidant activity, and their regular intake would be effective for cancer prevention 7 .…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, a standard system pharmacology approach was applied to assess the mechanism features of Chrysanthemum extracts in treating breast cancer. For this purpose, we first selected and screened the major compounds of Chrysanthemum from our previous report 6 . Then, we utilized on-line databases to obtain the breast cancer targets and performed molecular docking to validate the targets.…”

Section: Introductionmentioning

confidence: 99%

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Anticancer drug discovery from Iranian Chrysanthemum cultivars through system pharmacology exploration and experimental validation

Hodaei

Rahimmalek

Behbahani

2021

Sci Rep

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Breast cancer is the most common carcinoma in women, and natural products would be effective preventing some side effects of cancer treatment. In the present study, cytotoxic activities of different Iranian Chrysanthemum morifolium cultivars were evaluated in human breast cancer cell lines (MCF-7) and human lymphocytes. A systems pharmacology approach was employed between major compounds of these cultivars (chlorogenic acid, luteolin, quercetin, rutin, ferulic acid, and apigenin) and known breast cancer drugs (tucatinib, methotrexate, tamoxifen, and mitomycin) with 22 breast cancer-related targets to analyze the mechanism through which Chrysanthemum cultivars act on breast cancer. Target validation was performed by the molecular docking method. The results indicated that Chrysanthemum extracts inhibited the proliferation of MCF7 cells in a dose- and cultivar-dependent manner. In all studied cultivars, the most effective extract concentration with the lowest viability of MCF-7 cells, was as much as 312 µg ml−1. Also, higher concentrations of the extracts (> 1000 µg ml−1) reduced the lymphocyte cell viability, demonstrating that these doses were toxic. The gene ontology analysis revealed the therapeutic effects of Chrysanthemum’s active compounds on breast cancer by regulating the biological processes of their protein targets. Moreover, it has been documented that rutin, owing to its anticancer effects and several other health benefits, is a promising multi-targeted herbal ingredient. Finally, the present study compared different Iranian Chrysanthemum cultivars to provide new insights into useful pharmaceutical applications.

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Section: Discussionmentioning

confidence: 72%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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