Variation in human water turnover associated with environmental and lifestyle factors

Yamada, Yosuke; Zhang, Xueying; Henderson, Mary E.; Sagayama, Hiroyuki; Pontzer, Herman; Watanabe, Daiki; Yoshida, Tsukasa; Kimura, Misaka; Ainslie, Philip N.; Andersen, Lene Frost; Anderson, Liam; Arab, Lenore; Baddou, Issad; Bedu-Addo, Kweku; Blaak, Ellen E.; Blanc, Stéphane; Bonomi, A.; Bouten, Cvc Carlijn; Bovet, Pascal; Buchowski, Maciej S.; Butte, Nancy F.; Camps, Stefan Gerardus; Close, Graeme L.; Cooper, Jamie A.; Cooper, Richard S.; Das, Sai Krupa; Dugas, Lara R.; Eaton, Simon; Ekelund, Ulf; Entringer, Sonja; Forrester, Terrence; Fudge, Barry W.; Goris, Annelies H. C.; Gurven, Michael; Halsey, Lewis G.; Hambly, Catherine; Hamdouchi, Asmaa El; Hoos, Marije B.; Hu, Sumei; Joonas, Noorjehan; Joosen, Annemiek M.C.P.; Katzmarzyk, Peter T.; Kempen, Kitty P.; Kraus, William E.; Kriengsinyos, Wantanee; Kushner, Robert F.; Lambert, Estelle V.; Leonard, William R.; Lessan, Nader; Martin, Corby K.; Medin, Anine Christine; Meijer, Erwin P.; Morehen, James C; Morton, James P.; Neuhouser, Marian L.; Nicklas, Theresa A.; Ojiambo, Robert; Pietiläinen, Kirsi H.; Pitsiladis, Yannis; Plange‐Rhule, Jacob; Plasqui, Guy; Prentice, Ross L.; Rabinovich, Roberto; Racette, Susan B.; Raichlen, David A.; Ravussin, Éric; Redman, Leanne M.; Reilly, John J.; Reynolds, Rebecca M.; Roberts, Susan B.; Schuit, Albertine J.; Sardinha, Luís B.; Silva, Analiza M.; Sjödin, Anders; Stice, Eric; Urlacher, Samuel S.; Valenti, Giulio; Etten, Ludo M. Van; Mil, E.G.A.H. van; Wells, Jonathan C. K.; Wilson, George; Wood, Brian M.; Yanovski, Jack A.; Murphy‐Alford, Alexia J.; Loechl, Cornelia; Luke, Amy; Rood, Jennifer; Wong, William W.; Miyachi, Motohiko; Schoeller, Dale A.; Speakman, John R.

doi:10.1126/science.abm8668

Cited by 46 publications

(52 citation statements)

References 37 publications

(59 reference statements)

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“…This predicted average value compared well with the reported mean water excretion of 900 ml/day from 78 male babies aged between 8 and 180 days (mean=36 days). 38 Notably, the predicted water excretion on day 30 was 810 ml/day. It is important to note that these predicted output values also accounted for the metabolic production of water, which was between 56 ml/day and 169 ml/day (Table S6 (A)), highlighting that overall the infant-WBMs realistically captured water production and consumption.…”

Section: Resultsmentioning

confidence: 99%

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Personalised metabolic whole-body models for newborns and infants predict growth and biomarkers of inherited metabolic diseases

Zaunseder,

Mütze,

Okun

et al. 2023

Preprint

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Extensive whole-body models (WBMs) accounting for organ-specific dynamics have been developed to simulate adult metabolism. However, there is currently a lack of models representing infant metabolism taking into consideration its special requirements in energy balance, nutrition, and growth. Here, we present a resource of organ-resolved, sex-specific, anatomically accurate models of newborn and infant metabolism, referred to as infant-whole-body models (infant-WBMs), spanning the first 180 days of life. These infant-WBMs were parameterised to represent the distinct metabolic characteristics of newborns and infants accurately. In particular, we adjusted the changes in organ weights, the energy requirements of brain development, heart function, and thermoregulation, as well as dietary requirements and energy requirements for physical activity. Subsequently, we validated the accuracy of the infant-WBMs by showing that the predicted neonatal and infant growth was consistent with the recommended growth by the World Health Organisation. We assessed the infant-WBMs' reliability and capabilities for personalisation by simulating 10,000 newborn models, personalised with blood concentration measurements from newborn screening and birth weight. Moreover, we demonstrate that the models can accurately predict changes over time in known blood biomarkers in inherited metabolic diseases. By this, the infant-WBM resource can provide valuable insights into infant metabolism on an organ-resolved level and enable a holistic view of the metabolic processes occurring in infants, considering the unique energy and dietary requirements as well as growth patterns specific to this population. As such, the infant-WBM resource holds promise for personalised medicine, as the infant-WBMs could be a first step to digital metabolic twins for newborn and infant metabolism for personalised systematic simulations and treatment planning.

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Section: Resultsmentioning

confidence: 99%

“…In addition, metabolic water is produced inside a living organism as an end product of the oxidation of energy-containing substances in their food. 38 Here, we determined whether the infant-WBMs could correctly predict water loss. Therefore, we computed the flux distribution through each infant-WBM (Method section).…”

Section: Resultsmentioning

confidence: 99%

Personalised metabolic whole-body models for newborns and infants predict growth and biomarkers of inherited metabolic diseases

Zaunseder,

Mütze,

Okun

et al. 2023

Preprint

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show abstract

“…At 10 years old, there is between 15 and 25 L depending on sex and age, and at 18 years old between 35 and 50 L for boys and between 25 and 38 L for girls [ 39 , 40 , 41 ]. A new method using isotope tracking (2 H) allows investigation of water turnover (water used by the body each day), confirming that age and body size were significantly associated with water turnover, as were physical activity, socioeconomic status, and environmental characteristics (altitude, air temperature) [ 42 ].…”

Section: Overall Benefits Of Hydrationmentioning

confidence: 99%

Hydration and Nephrolithiasis in Pediatric Populations: Specificities and Current Recommendations

et al. 2023

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Renal lithiasis is less frequent in children than in adults; in pediatrics, lithiasis may be caused by genetic abnormalities, infections, and complex uropathies, but the association of urological and metabolic abnormalities is not uncommon. The aim of this study is to provide a synthesis of nephrolithiasis in children and to emphasize the role of hydration in its treatment. As an etiology is reported in 50% of cases, with a genetic origin in 10 to 20%, it is proposed to systematically perform a complete metabolic assessment after the first stone in a child. Recent data in the field reported increased incidence of pediatric urolithiasis notably for calcium oxalate stones. These changes in the epidemiology of stone components may be attributable to metabolic and environmental factors, where hydration seems to play a crucial role. In case of pediatric urolithiasis, whatever its cause, it is of utmost importance to increase water intake around 2 to 3 L/m2 per day on average. The objective is to obtain a urine density less than 1010 on a dipstick or below 300 mOsm/L, especially with the first morning urine. Some genetic diseases may even require a more active 24 h over-hydration, e.g., primary hyperoxaluria and cystinuria; in such cases naso-gastric tubes or G-tubes may be proposed. Tap water is adapted for children with urolithiasis, with limited ecological impact and low economical cost. For children with low calcium intake, the use of calcium-rich mineral waters may be discussed in some peculiar cases, even in case of urolithiasis. In contrast, sugar-sweetened beverages are not recommended. In conclusion, even if parents and patients sometimes have the feeling that physicians do not propose “fancy” therapeutic drugs, hydration and nutrition remain cornerstones of the management of pediatric urolithiasis.

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“…Not exactly. New research in Science shows the recommended intake of two litres, or eight glasses of water, a day is too high for most people 1…”

Section: Know This One—eight Glasses Of Water a Day Right?mentioning

confidence: 99%

Sixty seconds on . . . hydration

Wise¹

2022

BMJ

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Variation in human water turnover associated with environmental and lifestyle factors

Cited by 46 publications

References 37 publications

Personalised metabolic whole-body models for newborns and infants predict growth and biomarkers of inherited metabolic diseases

Personalised metabolic whole-body models for newborns and infants predict growth and biomarkers of inherited metabolic diseases

Hydration and Nephrolithiasis in Pediatric Populations: Specificities and Current Recommendations

Sixty seconds on . . . hydration

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