Variation in platelet expression of FcγRIIa after myocardial infarction

McMahon, Sean; Chava, Sreedivya; Taatjes-Sommer, Heidi S.; Meagher, Sean; Brummel‐Ziedins, Kathleen E.; Schneider, David J.

doi:10.1007/s11239-019-01852-7

Cited by 9 publications

(6 citation statements)

References 29 publications

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“…[61] FCGR2A encodes one member of a family of immunoglobulin fold change receptor genes found on the surface of many immune response cells. [62] Proteomics analysis showed that FCGR2A mediates angiogenesis in a rodent model of vascular disease. [63] The protein encoded by IL10RA is a receptor for interleukin 10.…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics study on different gene expression profiles of fibroblasts and vascular endothelial cells in keloids

2021

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Keloid is a benign fibroproliferative skin tumor. The respective functions of fibroblasts and vascular endothelial cells in keloid have not been fully studied. The purpose of this study is to identify the respective roles and key genes of fibroblasts and vascular endothelial cells in keloids, which can be used as new targets for diagnosis or treatment.The microarray datasets of keloid fibroblasts and vascular endothelial cells were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were screened out. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used for functional enrichment analysis. The search tool for retrieval of interacting genes and Cytoscape were used to construct protein-protein interaction (PPI) networks and analyze gene modules. The hub genes were screened out, and the relevant interaction networks and biological process analysis were carried out.In fibroblasts, the DEGs were significantly enriched in collagen fibril organization, extracellular matrix organization and ECM-receptor interaction. The PPI network was constructed, and the most significant module was selected, which is mainly enriched in ECM-receptor interaction. In vascular endothelial cells, the DEGs were significantly enriched in cytokine activity, growth factor activity and transforming growth factor-β (TGF-β) signaling pathway. Module analysis was mainly enriched in TGF-β signaling pathway. Hub genes were screened out separately.In summary, the DEGs and hub genes discovered in this study may help us understand the molecular mechanisms of keloid, and provide potential targets for diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

Bioinformatics study on different gene expression profiles of fibroblasts and vascular endothelial cells in keloids

2021

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“…To our best knowledge, most of the studies on FCGR2A have been focused on the inflammation and cerebral vascular diseases. For instance, in a recent study, there was variation in the expression of the FCGR2A gene in the platelets after onset of myocardial infarction [ 24 ]. Besides, FCGR2A single nucleotide polymorphism conferred susceptibility to childhood-onset idiopathic nephrotic syndrome [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

FCGR2A Could Function as a Prognostic Marker and Correlate with Immune Infiltration in Head and Neck Squamous Cell Carcinoma

Dai

Chen

Huang

et al. 2021

BioMed Research International

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Objective. We aim to investigate the correlation between FCGR2A mRNA level and prognosis of head and neck squamous cancer (HNSC) in public databases. In addition, we investigated the correlation between FCGR2A expression and clinicopathological characteristics and tumor-infiltrating immune cells in HNSC patients. Methods. FCGR2A mRNA expression in multiple cancers was analyzed based on Gene Expression Profiling Interactive Analysis. A protein-protein interaction network was obtained based on the STRING database. The 10 proteins most closely related to FCGR2A (i.e., CD3G, PLCG2, LAT, LYN, SYK, FCGR3A, PIK3R1, HCK, ITGAM, and ITGB2) were screened, followed by establishing the protein-protein interaction network. The correlation between FCGR2A expression and immunocytes was investigated, together with the effects of FCGR2A on the metastasis, recurrence, and survival of HNSC. Results. FCGR2A expression in several carcinoma tissues was significantly higher than that of adjacent tissues. Significant differences were noticed in the HNSC samples and the adjacent tissue samples except the seven samples of grade 4. There were statistical differences between the FCGR2A expression in tissues of grade 1, grade 2, and grade 3 ( P < 0.05 ). In the tissues of grade 4, the expression of FCGR2A was the lowest. The FCGR2A protein was a type of II-a receptor in γFc of the low-affinity immunoglobulin, which could bind with the Fc region of the immunoglobulin γ. There was a correlation between the FCGR2A gene and the distal HNSC metastasis. FCGR2A gene expression was correlated with the survival and prognosis. The GSE65858 dataset was selected for the validation. The FCGR2A expression was significantly correlated with total survival ( P = 0.0107 ) and progression-free survival ( P = 0.0362 ). Conclusions. Our findings shed light on the importance of FCGR2A in HNSC and illustrated a potential relationship between FCGR2A and tumor-immune interactions.

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“…In a single center study, we found that high platelet FcγRIIa expression (≥11,000/platelet) is associated with a greater risk (odds ratio > 4) of myocardial infarction (MI), stroke and death (26). Platelet FcγRIIa expression does not require activation of platelets and does not exhibit the magnitude of intra-individual variability seen with platelet function tests (27). The emphasis on platelet activation directly focuses our stroke prevention efforts in ICAD where anti-platelets have been paramount and shear-induced platelet aggregation pivotal.…”

Section: Platelet Reactivity and Platelet Expression Of Fcγriiamentioning

confidence: 99%

Endothelial Shear Stress and Platelet FcγRIIa Expression in Intracranial Atherosclerotic Disease

et al. 2021

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Intracranial atherosclerotic disease (ICAD) has been characterized by the degree of arterial stenosis and downstream hypoperfusion, yet microscopic derangements of endothelial shear stress at the luminal wall may be key determinants of plaque growth, vascular remodeling and thrombosis that culminate in recurrent stroke. Platelet interactions have similarly been a principal focus of treatment, however, the mechanistic basis of anti-platelet strategies is largely extrapolated rather than directly investigated in ICAD. Platelet FcγRIIa expression has been identified as a potent risk factor in cardiovascular disease, as elevated expression markedly increases the risk of recurrent events. Differential activation of the platelet FcγRIIa receptor may also explain the variable response of individual patients to anti-platelet medications. We review existing data on endothelial shear stress and potential interactions with the platelet FcγRIIa receptor that may alter the evolving impact of ICAD, based on local pathophysiology at the site of arterial stenosis. Current methods for quantification of endothelial shear stress and platelet activation are described, including tools that may be readily adapted to the clinical realm for further understanding of ICAD.

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Variation in platelet expression of FcγRIIa after myocardial infarction

Cited by 9 publications

References 29 publications

Bioinformatics study on different gene expression profiles of fibroblasts and vascular endothelial cells in keloids

Bioinformatics study on different gene expression profiles of fibroblasts and vascular endothelial cells in keloids

FCGR2A Could Function as a Prognostic Marker and Correlate with Immune Infiltration in Head and Neck Squamous Cell Carcinoma

Endothelial Shear Stress and Platelet FcγRIIa Expression in Intracranial Atherosclerotic Disease

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