Variation in synergistic activity by flavone and its related compounds on the increased susceptibility of various strains of methicillin-resistant Staphylococcus aureus to β-lactam antibiotics

Sato, Youichi; Shibata, Hirofumi; Arai, Tsutomu; Yamamoto, Akira; Okimura, Yousuke; Arakaki, Naokatu; Higuti, Tomihiko

doi:10.1016/j.ijantimicag.2004.02.028

Cited by 45 publications

(39 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, there is an urgent need to search for new antibiotics or better treatments to save lives and shorten hospital stays (Andersson & Hughes, 2010;Baker, 2006;Fox, 2006). Many recent studies have reported the discovery of novel compound or extract with antimicrobial activity from the herbal medicine (Chattopadhyay et al, 2002;Peng et al, 2012;Sato et al, 2004). From the results of present study, XYT showed a broader antimicrobial spectrum and stronger toxicity to the tested microbes.…”

Section: Discussionmentioning

confidence: 49%

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Liu

Peng

et al. 2013

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: Qi-Wei-Xiao-Yan-Tang (XYT), composed of Radix et Rhizoma Rhei, Radix Astragali, Radix Wikstroemiae Indicae, Fructus Ligustri Lucidi, Poria and Radix Glycyrrhizae, has been widely used as an anti-inflammatory drug.Objective: The present study investigated the anti-inflammatory, antibacterial effects and serum pharmacochemistry of XYT. Methods: The dimethylbenzene-induced inflammation test, the acetic acid-induced vascular permeability test and the carrageenan-induced paw edema test were used to evaluate the antiinflammatory activity of XYT (200, 100 and 50 mg/kg); minimal inhibitory concentration (MIC). Minimal bactericidal concentration (MBC) tests were used to evaluate the antibacterial activity of XYT. Additionally, serum pharmacochemistry was performed to study the biologically active substances. Results: All the tests for anti-inflammatory effects were shown active with these test systems; the anti-inflammatory effects at doses of 100 and 200 mg/kg were significant (p50.05); MIC and MBC tests indicated that XYT showed a broader antimicrobial spectrum and stronger toxicity to the tested microbes. Additionally, calycosin-7-glucoside, sennoside A, aloeemodin and rhein were detected as the predominant components in rat serum which may play the key role in the anti-inflammatory activities of XYT. Conclusions: This is the first report of the pharmacological activities and serum pharmacochemistry of XYT, and the first evidence of anti-inflammatory and antimicrobial properties of the extracts of XYT. The results of our work demonstrated that XYT has significant antiinflammatory and antibacterial properties, and calycosin-7-glucoside, sennoside A aloeemodin and rhein may be the biologically active substances of XYT. XYT can be utilized as an effective and safe disease preventive or therapeutic agent.

show abstract

Section: Discussionmentioning

confidence: 49%

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Liu

Peng

et al. 2013

Pharmaceutical Biology

View full text Add to dashboard Cite

show abstract

“…After that, active fraction was purified by HPLC on Inertsil ODS-3 (1 by 25 cm, GL science Co.) using 60% acetonitrile as an eluant. Twenty milligrams of the active compound was isolated and its structure was determined by 1 H-, 13 C-NMR and MS spectrum.…”

Section: Isolation Of Effective Compoundsmentioning

confidence: 99%

“…Until now, we and other groups have reported many compounds that potentiated activity of antimicrobial agents against drug-resistant bacteria. For example, corilagin, 8,9) tellimagrandin I, 9,10) epicatechin gallate, 11) epigallocatechin gallate 12) or many flavonoids 13) potentiated antibacterial activity of b-lactams against methicillin-resistant Staphylococcus aureus (MRSA). Baicalein potentiated activities of tetracycline and b-lactams against MRSA, 14) 5Ј-methoxyhydonocarpin inhibited NorA pump in S. aureus 15) and MC-207,110 (phenylalanine arginine bnaphthylamide, PAbN) and its relatives potentiated some types of antimicrobials that are substrates of one of multidrug efflux pumps, MexAB-OprM of Pseudomonas aeruginosa [16][17][18][19][20][21] or AcrAB-TolC of Escherichia coli 22) and Enterobacter aerogenes.…”

mentioning

confidence: 99%

Potentiation of Antimicrobial Activity of Aminoglycosides by Carnosol from Salvia officinalis

Horiuchi

Shiota

Kuroda

et al. 2007

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

We found that a crude extract from Salvia officinalis (sage) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). We isolated the effective compound from the extract and identified it as carnosol, one of diterpenoids. Carnosol showed a weak antimicrobial activity, and greatly reduced the MICs of various aminoglycosides (potentiated the antimicrobial activity of aminoglycosides) and some other types of antimicrobial agents in VRE. Carnosic acid, a related compound, showed the similar activity. The effect of carnosol and carnosic acid with gentamicin was synergistic.

show abstract

“…Effects of ZP-CT-A on -lactamase activity Since the mechanisms concerning the inhibition oflactam 21,22) and the disruption of the cell membrane [23][24][25][26][27] were thought to be included in the effect of natural substances on the antibiotic-resistant bacteria, we examined those effects of ZP-CT-A. First, we examined the effect on -lactamase activity using strain PC1, which produces -lactamase constitutively, but not PBP 2a.…”

Section: Cooperative Effects Of Zp-ct-a and Oxacillin On The Growth Pmentioning

confidence: 99%

Polyphenolic Constituent Structures ofZanthoxylum piperitumFruit and the Antibacterial Effects of Its Polymeric Procyanidin on Methicillin-ResistantStaphylococcus aureus

Kusuda

Inada

Ogawa

et al. 2006

Bioscience, Biotechnology, and Biochemistry

View full text Add to dashboard Cite

Variation in synergistic activity by flavone and its related compounds on the increased susceptibility of various strains of methicillin-resistant Staphylococcus aureus to β-lactam antibiotics

Cited by 45 publications

References 40 publications

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Bioactivities and serum pharmacochemistry ofQi-Wei-Xiao-Yan-Tang

Potentiation of Antimicrobial Activity of Aminoglycosides by Carnosol from Salvia officinalis

Polyphenolic Constituent Structures ofZanthoxylum piperitumFruit and the Antibacterial Effects of Its Polymeric Procyanidin on Methicillin-ResistantStaphylococcus aureus

Contact Info

Product

Resources

About