Variation in the miRNA-433 binding site of FGF20 is a risk factor for Parkinson's disease in Iranian population

Haghnejad, Leyla; Emamalizadeh, Babak; Jamshidi, Javad; Bidoki, Alireza Zare; Ghaedi, Hamid; Ahmadi, Ehsan; Abdollahi, Shokoufeh; Shahmohammadibeni, Neda; Taghavi, Shaghayegh; Fazeli, Atena; Motallebi, Marzieh; Zarneh, Amir Ehtesham Shafiei; Mohammadihosseinabad, Saeed; Abbaszadegan, Mohammad Reza; Torkamandi, Shahram; Gavenaroudi, Masoumeh Amini; Pedram, Negar; Shahidi, Gholam Ali; Tafakhori, Abbas; Darvish, Hossein; Movafagh, Abolfazl

doi:10.1016/j.jns.2015.05.020

Cited by 23 publications

(5 citation statements)

References 19 publications

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“…HLA-C alleles containing this indel escape miRNA-mediated repression, leading to higher cell surface levels of HLA-C that are associated with significantly lower viral load 68 . Other miRNA–mRNA interactions that are affected by genetic variants that cause reduced miRNA binding and increased target protein expression include: the miR-485-5p– APOA5 interaction as a risk factor for hyper triglyceridaemia, the hsa-miR-671-5p– BCL2L12 interaction as a risk factor for melanoma, the miR-433– FGF20 interaction as a risk factor for Parkinson disease in some populations and various miRNA–mRNA interactions that are associated with cardiometabolic phenotypes 62,69–72 .…”

Section: Variants Affect Mirna-mediated Regulationmentioning

confidence: 99%

The roles of RNA processing in translating genotype to phenotype

Manning

Cooper

2016

Nat Rev Mol Cell Biol

179

141

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A goal of human genetics studies is to determine the mechanisms by which genetic variation produces phenotypic differences that affect human health. Efforts in this respect have previously focused on genetic variants that affect mRNA levels by altering epigenetic and transcriptional regulation. Recent studies show that genetic variants that affect RNA processing are at least equally as common as, and are largely independent from, those variants that affect transcription. We highlight the impact of genetic variation on pre-mRNA splicing and polyadenylation, and on the stability, translation and structure of mRNAs as mechanisms that produce phenotypic traits. These results emphasize the importance of including RNA processing signals in analyses to identify functional variants.

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Section: Variants Affect Mirna-mediated Regulationmentioning

confidence: 99%

The roles of RNA processing in translating genotype to phenotype

Manning

Cooper

2016

Nat Rev Mol Cell Biol

179

141

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“…The discovery that SNPs located within the miR-433 binding sites in FGF20 gene were associated with PD (van der Walt et al, 2004; Haghnejad et al, 2015) triggered two studies to investigate the potential impact of miR-433 in α-synuclein expression (Wang et al, 2008; Schmitt et al, 2012). Wang et al (2008) first demonstrated that miR-433 directly targets the FGF20 mRNA transcript and negatively regulates FGF20 protein translation.…”

Section: Resultsmentioning

confidence: 99%

Role of microRNAs in the Regulation of α-Synuclein Expression: A Systematic Review

Recasens

Perier

Sue

2016

Front. Mol. Neurosci.

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Growing evidence suggests that increased levels of α-synuclein might contribute to the pathogenesis of Parkinson’s disease (PD) and therefore, it is crucial to understand the mechanisms underlying α-synuclein expression. Recently, microRNAs (miRNAs) have emerged as key regulators of gene expression involved in several diseases such as PD and other neurodegenerative disorders. A systematic literature search was performed here to identify microRNAs that directly or indirectly impact in α-synuclein expression/accumulation and describe its mechanism of action. A total of 27 studies were incorporated in the review article showing evidences that six microRNAs directly bind and regulate α-synuclein expression while several miRNAs impact on α-synuclein expression indirectly by targeting other genes. In turn, α-synuclein overexpression also impacts miRNAs expression, indicating the complex network between miRNAs and α-synuclein. From the current knowledge on the central role of α-synuclein in PD pathogenesis/progression, miRNAs are likely to play a crucial role at different stages of PD and might potentially be considered as new PD therapeutic approaches.

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“…Malignant polyps constituted 13 (1.2%) of all cases. In a study from Sri Lanka it accounts for 4.8% of colon polyps (Wickramasinghe et al, 2014;Haghnejad et al, 2015). In most Iranian published articles, they account for 4%-5.5% of colon polyps (Eshghi et al, 2011;Mirzaie et al, 2016;Mirzaie et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic Features of Colorectal Polyps in Shahid Beheshti University of Medical Sciences (SBMU)

Ahadi

Nejad

Farahani

et al. 2019

Asian Pac J Cancer Prev

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Aim:This study was designed to report epidemiologic findings of polyps in Iranian patients, and predict histology of polyp regarding to demographic and colonoscopic findings. Background: Classification of colorectal polyps had been revised in the past two decades and there is a need for polyp categorization in the Iranian Health System. Patients and methods: In this retrospective study, the medical records of patients with colonoscopic diagnosis of polyp in pathology departments of SBMU affiliated teaching hospitals were reviewed. Patient's slides evaluated and demographics findings were assessed. The anatomical location, macroscopic appearance including size and histological assessment of all polyps were recorded. Results: From total number of 1106 polyps (detected in 862 patients), adenomatous polyps (638 [57.7%]) were the most prevalent findings, followed by colon mucosal tag (184[16.6%]), hyperplastic and serrated polyps (122[11%]), inflammatory polyps (110[9.9%]), hamartomatous (21[1.9%]), and malignant lesions (13[1.2%]). Multivariate logistic regression showed age (each one year increasing age; odds ratio [OR] = 1.026, 95%confidence interval [CI] = 1.016-1.036, p < 0.0001), location of polyp (right colon; OR = 1.905, 95%CI = 1.366-2.656, p < 0.0001), and polyp size of 5-10 mm (OR = 1.662, 95%CI = 1.214-2.276, p = 0.002), and polyp size of >10 mm (OR = 2.778, 95%CI = 1.750-4.411, p< 0.0001) were independently associated with neoplastic polyps. Also, polyp size of >10 mm (OR= 2.613, 95%CI= 1.083-6.307, p=0.033), tubulovillous pattern of polyp (OR= 3.508, 95%CI= 1.666-7.387, p=0.001) and villous pattern of polyp (OR= 10.444, p<0.0001) were associated with high grade dysplasia in neoplastic polyps. Conclusion: Increased age, location of polyp (right colon), increased size of polyp and villous component of polyp could classify patients in high risk groups.

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Variation in the miRNA-433 binding site of FGF20 is a risk factor for Parkinson's disease in Iranian population

Cited by 23 publications

References 19 publications

The roles of RNA processing in translating genotype to phenotype

The roles of RNA processing in translating genotype to phenotype

Role of microRNAs in the Regulation of α-Synuclein Expression: A Systematic Review

Clinicopathologic Features of Colorectal Polyps in Shahid Beheshti University of Medical Sciences (SBMU)

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