Variation in the Oxytocin Receptor Gene Is Associated With Social Cognition and ADHD

Kalyoncu, Tuğba; Özbaran, Burcu; Köse, Sezen; Önay, Hüseyin

doi:10.1177/1087054717706757

Cited by 24 publications

(16 citation statements)

References 62 publications

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“…Genetic and epigenetic studies consistently show associations between the oxytocin receptor gene (OXTR) and ASD (Gregory et al ., 2009). Genetic studies have not supported a role of the OXTR in ADHD (Park et al ., 2010; Kalyoncu et al ., 2017), but youth with ADHD have lower serum levels of oxytocin than neurotypical controls (Sasaki et al ., 2015).…”

Section: Introductionmentioning

confidence: 99%

Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis

et al. 2018

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Experts have raised concerns that oxytocin for labor induction and augmentation may have detrimental effects on the neurodevelopment of children. To investigate whether there is the reason for concern, we reviewed and evaluated the available evidence by searching databases with no language or date restrictions up to 9 September 2018. We included English-language studies reporting results on the association between perinatal oxytocin exposure and any cognitive impairment, psychiatric symptoms or disorders in childhood. We assessed the quality of studies using the Newcastle–Ottawa Quality Assessment Scales. Independent risk estimates were pooled using random-effects meta-analyses when at least two independent datasets provided data on the same symptom or disorder. Otherwise, we provided narrative summaries. Two studies examined cognitive impairment, one examined problem behavior, three examined attention-deficit/hyperactivity disorder (ADHD) and seven focused on autism spectrum disorders (ASD). We provided narrative summaries of the studies on cognitive impairment. For ADHD, the pooled risk estimate was 1.17; 95% confidence interval (CI) 0.77–1.78, based on a pooled sample size of 5 47 278 offspring. For ASD, the pooled risk estimate was 1.10; 95% CI 1.04–1.17, based on 8 87 470 offspring. Conclusions that perinatal oxytocin increases the risks of neurodevelopmental problems are premature. Observational studies of low to high quality comprise the evidence-base, and confounding, especially by the genetic or environmental vulnerability, remains an issue. Current evidence is insufficient to justify modifying obstetric guidelines for the use of oxytocin, which state that it should only be used when clinically indicated.

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Section: Introductionmentioning

confidence: 99%

Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis

et al. 2018

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“…There certainly are more human SNPs that merit investigation. For example, an association has been found between the rs4686302 SNP and social cognition deficits (e.g., facial emotion recognition) in children with ADHD (Kalyoncu et al, 2017 ). Especially interesting for dog-human comparisons, this SNP might be functionally similar to the canine rs851376227 located in the last exon of OXTR.…”

Section: Discussionmentioning

confidence: 99%

Gaze-Following and Reaction to an Aversive Social Interaction Have Corresponding Associations with Variation in the OXTR Gene in Dogs but Not in Human Infants

et al. 2017

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It has been suggested that dogs' remarkable capacity to use human communicative signals lies in their comparable social cognitive skills; however, this view has been questioned recently. The present study investigated associations between oxytocin receptor gene (OXTR) polymorphisms and social behavior in human infants and dogs with the aim to unravel potentially differential mechanisms behind their responsiveness to human gaze. Sixteen-month-old human infants (N = 99) and adult Border Collie dogs (N = 71) participated in two tasks designed to test (1) their use of gaze-direction as a cue to locate a hidden object, and (2) their reactions to an aversive social interaction (using the still face task for children and a threatening approach task for dogs). Moreover, we obtained DNA samples to analyze associations between single nucleotide polymorphisms (SNP) in the OXTR (dogs: −213AG, −94TC, −74CG, rs8679682, children: rs53576, rs1042778, rs2254298) and behavior. We found that OXTR genotype was significantly associated with reactions to an aversive social interaction both in dogs and children, confirming the anxiolytic effect of oxytocin in both species. In dogs, the genotypes linked to less fearful behavior were associated also with a higher willingness to follow gaze whereas in children, OXTR gene polymorphisms did not affect gaze following success. This pattern of gene-behavior associations suggests that for dogs the two situations are more alike (potentially fear-inducing or competitive) than for human children. This raises the possibility that, in contrast to former studies proposing human-like cooperativeness in dogs, dogs may perceive human gaze in an object-choice task in a more antagonistic manner than children.

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“…When OT-R gen was sequenced, three SNPs were associated with social deficit in children with ADHD. Therefore, a strong correlation was described for the CT/TT genotype of rs4686302 and low facial emotion recognition task [ 22 ], suggesting that rs4686302 polymorphism could be a genetic indicator of social dysfunction in ADHD pediatric patients.…”

Section: Neuropsychiatric Conditions: Ot and Avp Rolementioning

confidence: 99%

“…In addition, the possible involvement of both NPs in the physiopathology of a variety of neuropsychiatric conditions, has been documented. For example, altered plasma levels of OT, as well as OT-R polymorphisms, have been associated with ADHD [ 21 , 22 ] or ASD [ 23 ]. Furthermore, low levels of AVP in cerebrospinal fluid (CSF) have been suggested as an early biomarker of ASD [ 24 ], whereas social recognition impairment due to early life stress is associated with a dulled response of AVP release in lateral septum (LS) in rats [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists

Cid-Jofré

Moreno

Reyes‐Parada

et al. 2021

IJMS

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Oxytocin (OT) and vasopressin (AVP) are hypothalamic neuropeptides classically associated with their regulatory role in reproduction, water homeostasis, and social behaviors. Interestingly, this role has expanded in recent years and has positioned these neuropeptides as therapeutic targets for various neuropsychiatric diseases such as autism, addiction, schizophrenia, depression, and anxiety disorders. Due to the chemical-physical characteristics of these neuropeptides including short half-life, poor blood-brain barrier penetration, promiscuity for AVP and OT receptors (AVP-R, OT-R), novel ligands have been developed in recent decades. This review summarizes the role of OT and AVP in neuropsychiatric conditions, as well as the findings of different OT-R and AVP-R agonists and antagonists, used both at the preclinical and clinical level. Furthermore, we discuss their possible therapeutic potential for central nervous system (CNS) disorders.

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Variation in the Oxytocin Receptor Gene Is Associated With Social Cognition and ADHD

Abstract: OXTR rs4686302 polymorphism was shown to be a genetic marker in social cognition deficits in ADHD children.

Cited by 24 publications

References 62 publications

Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis

Assessing risk of neurodevelopmental disorders after birth with oxytocin: a systematic review and meta-analysis

Gaze-Following and Reaction to an Aversive Social Interaction Have Corresponding Associations with Variation in the OXTR Gene in Dogs but Not in Human Infants

Role of Oxytocin and Vasopressin in Neuropsychiatric Disorders: Therapeutic Potential of Agonists and Antagonists

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