Variation in the phytochemical contents and antioxidant activity of Glycyrrhiza glabra populations collected in Iran

Esmaeili, Hassan; Karami, Akbar; Hadian, Javad; Saharkhiz, Mohammad Jamal; Ebrahimi, Samad Nejad

doi:10.1016/j.indcrop.2019.05.034

Cited by 51 publications

(46 citation statements)

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“…Such variation could be related to several environmental factors and likely adaptation replies of various accessions, resulting in different secondary metabolites and volatile constituents being formed in the plants [48] . Precipitation, temperature, altitude, and edaphic features have been recorded as the dominant environmental effects, which determined the volatile oil composition and morphological descriptors [49,50] . Hence, for the introduction and domestication of a medicinal plant into cultivation, the survey of its habitat features is inevitable.…”

Section: Resultsmentioning

confidence: 99%

“…Mean values refer to colors from minimum displayed in bright green to maximum represented with red. b) PDA‐HPLC diagram that shows the relative values of 3.4‐dihydroxybenzoic acid, [2] 25‐dihydroxybenzoic acid, [2] chlorogenic acid, [2] vanillic acid, [50] caffeic acid (5), p‐ coumaric acid, [58] ferulic acid, [50] rosmarinic acid, [2] and rutin [2] in the studied accession of Mentha longifolia L. c) Biplot of PCA analysis based on targeted PDA‐HPLC analyses for phenolic compounds.…”

Section: Resultsmentioning

confidence: 99%

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Association of Genetic Structure and Diversity in Iranian Wild Germplasms ofMentha longifoliaL. Based on Phenotypical, Biochemical, and Molecular Markers

Araghi

Nemati

Azizi

et al. 2021

Chemistry & Biodiversity

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Mentha longifolia L. is well‐known to be one of the most pervasive wild‐growing species of the Lamiaceae family, which has extensive beneficial properties in the fields of pharmacology and biological products. In the present study, the correlation between Inter‐simple sequence repeat (ISSR) markers and morpho‐chemical parameters of twenty different M. longifolia accessions (MLACs) were assessed. The geographic information system (GIS) has been employed to interpret the original habitat of the accessions in Iran. ISSR analysis indicated a remarkable difference in the studied accessions, segregated them into three main groups, constructed by an unweighted pair‐group method with arithmetic (UPGMA) and principal coordinate analysis (PCoA). A total of 89 bands were generated by 12 ISSR primers, among which 82 (91.97 %) of them were polymorphic. The cluster analysis based on agro‐morphological data scattered MLACs into two main groups. The essential oils (EOs) were analyzed through GC/FID/MS, and four chemotypes were characterized according to the major constituents. Pulegone ranged from 0.17 to 69.50 % was the main oil constituent with the highest content. Also, HPLC‐PDA was employed to identify and to quantify the phenolic compounds in the MeOH extracts of MLACs. Heatmap cluster based on phenolic compounds produced three main categories of accessions. The components identified in the extracts were rosmarinic acid, rutin, vanillic acid, ferulic acid, chlorogenic acid, caffeic acid, 3,4‐dihydroxybenzoic acid, 2,5‐dihydroxybenzoic acid, and p‐coumaric acid, which among them rosmarinic acid (RA) varied from 39.16 to 261.55 mg/100 g (DW) as a predominant constituent. Subsequently, multiple regression analyses between ISSR fragments and morpho‐chemical data illustrated considerable relationships in the plant materials. The high variation and correlation observed in metabolic and phenotypic traits of MLACs establish an adequate source to conduct reserves conservation programs.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Association of Genetic Structure and Diversity in Iranian Wild Germplasms ofMentha longifoliaL. Based on Phenotypical, Biochemical, and Molecular Markers

Araghi

Nemati

Azizi

et al. 2021

Chemistry & Biodiversity

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“…Different topographical, climatic, and soil datasets for a study area are necessary to identify suitable habitat zones with appropriate GIS-based models [ 29 , 30 ]. In this study, the topographical features (slope, aspect, curvature, hillshade, and elevation), soil conditions (pH, soil bearing capacity, and soil moisture content), and meteorological information (annual mean temperature and annual mean precipitation) were investigated.…”

Section: Methodsmentioning

confidence: 99%

Phytochemical Analysis and Habitat Suitability Mapping of Glycyrrhiza glabra L. Collected in the Hatay Region of Turkey

et al. 2020

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The growth and quality of licorice depend on various environmental factors, including the local climate and soil properties; therefore, its cultivation is often unsuccessful. The current study investigated the key factors that affect the contents of bioactive compounds of Glycyrrhiza glabra L. root and estimated suitable growth zones from collection sites in the Hatay region of Turkey. The contents of three bioactive compounds (glycyrrhizic acid, glabridin, and liquiritin), soil factors (pH, soil bearing capacity, and moisture content), and geographical information (slope, aspect, curvature, elevation, and hillshade) were measured. Meteorological data (temperature and precipitation) were also obtained. An analysis of variance (ANOVA) and multivariate analysis of variance (MANOVA) were performed on the data. The soil bearing capacity, moisture content, slope, aspect, curvature, and elevation of the study area showed statistically significant effects on the glycyrrhizic acid and liquiritin contents. A habitat suitability zone map was generated using a GIS-based frequency ratio (FR) model with spatial correlations to the soil, topographical, and meteorological data. The final map categorized the study area into four zones: very high (15.14%), high (31.50%), moderate (40.25%), and low suitability (13.11%). High suitability zones are recommended for further investigation and future cultivation of G. glabra.

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“…1). Geographical information of studied population is mentioned previously (Esmaeili et al, 2019). Roots of each population (2 cm diameter and 15 cm length) were planted in a randomized complete block design (RCBD) with 5 replications with the spacing of 60 × 40 cm (5 plants per replication).…”

Section: Plant Materialsmentioning

confidence: 99%

“…The TPC (Folin-Ciocalteu method) (Lister and Wilson, 2001), TFC (Aluminum Chloride method) (Chang et al, 2002) and antioxidant activity (DPPH method) (Geoffroy et al, 2017) were evaluated. GLY, LIQ, GLA and LI contents of ground root of the samples were evaluated using Knauer HPLC instrument according to the method described previously (Esmaeili et al, 2019). The extracts were passed through a 0.22 nm filter and stored in a 2 ml tube at 4 °C until analysis by HPLC.…”

Section: Phytochemical Traitsmentioning

confidence: 99%

High Heritability of Glycyrrhizic Acid, Glabridin, Liquiritin and Liquiritigenin in Licorice (Glycyrrhiza Glabra L.) Populations of Iran

Eghlima

Sanikhani

Kheiry

et al. 2021

Preprint

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Glycyrrhiza glabra L. is an herbaceous, perennial plant with high distribution in Iran. Genetic variability, heritability and correlation among characters in 22 populations of G. glabra L. were studied. The genetic parameters among the traits including phenotypic variances, genotypic variances, genotype by environment variances, broad-sense heritability and genotypic and phenotypic correlation coefficients were studied. Variance components analysis showed that the extent of phenotypic coefficient of variation (PCV) was fairly higher for all the examined traits compared with genotypic coefficient of variation (GCV). Glabridin (GLA) exhibited high GCV and PCV (156.07% and 156.68%, respectively). The broad sense heritability varied from 38.92–99.79% and narrow sense heritability ranged from 9.70 % to 24.94%. Heritability of GLA, glycyrrhizic acid (GLY), liquiritin (LI), liquiritigenin (LIQ), rutin (RU) and rosmarinic acid (RA) were very high, exhibiting more than 97% heritability. Therefore, these critical characteristics can efficiently be selected and inherited in breeding programs. In most traits, the genotypic correlations showed the same direction as the phenotypic correlations. The contents of GLA and LIQ showed a positive correlation with majority of morphological traits. Therefore, selecting individual plants having desired morphological traits can be correlated with high contents of bioactive compounds in the harvested root.

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Variation in the phytochemical contents and antioxidant activity of Glycyrrhiza glabra populations collected in Iran

Cited by 51 publications

References 30 publications

Association of Genetic Structure and Diversity in Iranian Wild Germplasms ofMentha longifoliaL. Based on Phenotypical, Biochemical, and Molecular Markers

Association of Genetic Structure and Diversity in Iranian Wild Germplasms ofMentha longifoliaL. Based on Phenotypical, Biochemical, and Molecular Markers

Phytochemical Analysis and Habitat Suitability Mapping of Glycyrrhiza glabra L. Collected in the Hatay Region of Turkey

High Heritability of Glycyrrhizic Acid, Glabridin, Liquiritin and Liquiritigenin in Licorice (Glycyrrhiza Glabra L.) Populations of Iran

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